Atypical Fibroxanthoma and Metastasis to the Lung

Kargι, Eksal; Güngör, Emel; Verdi, Mehmet; Kuiaçogiu, Sezer; Erdoğan, Bülent; Allı, Nuran

doi:10.1097/00006534-200304150-00032

Cited by 31 publications

(31 citation statements)

References 10 publications

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“…Historically, AFX has been regarded as a low‐grade malignancy, although recent literature has described a recurrence rate of approximately 6%, and tumors are better categorized as having intermediate malignant potential. Microsatellite and in‐transit metastases have been described, and there are reports of metastasis resulting in five deaths . The precise relationship between AFX and other spindle cell lesions, including MFH, SCC, and spindle cell melanoma, is somewhat controversial .…”

Section: Atypical Fibroxanthomamentioning

confidence: 99%

Spindle Cell Neoplasms Encountered in Dermatologic Surgery: A Review

Hollmig

Sachdev

Cockerell

et al. 2012

Dermatologic Surgery

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Cutaneous spindle cell tumors share the common feature of appearing as spindle-shaped cells on light microscopy. Their pathogenesis, presentation, and prognosis are highly variable, and numerous techniques for workup and treatment have been reported. We performed an analysis of the available scientific literature in order to codify the clinical, immunohistochemical, and biologic features of these tumors and to provide insight into the most effective practices for their management, with a focus on Mohs micrographic surgery (MMS). In this article, the clinical and histopathological characteristics of dermatofibrosarcoma protuberans, atypical fibroxanthoma, malignant fibrous histiocytoma, spindle cell squamous cell carcinoma, superficial leiomyosarcoma, desmoplastic melanoma, cutaneous angiosarcoma, and myofibrosarcoma are described, and methods for diagnosis, workup, treatment, and surveillance are evaluated. Cutaneous spindle cell neoplasms are diverse in origin, presentation, and behavior. Immunostaining assists in differentiating among the various types. Further workup is sometimes indicated to characterize local invasion or assess for metastatic disease. Surgery is typically the first-line treatment, and MMS is associated with low recurrence rates and a tissue-sparing advantage for many tumors. Adjuvant treatments, including radiation therapy, molecular-targeted therapy, and conventional chemotherapy, are sometimes indicated, and close clinical surveillance is required after treatment.

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Section: Atypical Fibroxanthomamentioning

confidence: 99%

Spindle Cell Neoplasms Encountered in Dermatologic Surgery: A Review

Hollmig

Sachdev

Cockerell

et al. 2012

Dermatologic Surgery

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“…Histologic findings of fibroblasts and mononuclear or multinucleated lipid-filled cells having the appearance of histiocytes with abundant vacuolated cytoplasm interspersed with fibrovascular septations and masses of cholesterol suggest the diagnosis [3]. Cells are negative for S-100 protein and positive for anti-human macrophage marker HAM-56, which indicates histiocyte lineage [3,5,10].…”

Section: Discussionmentioning

confidence: 99%

Case Report: Fibroxanthoma

Sadat-Ali

Azzam

Bluwi

et al. 2010

Clinical Orthopaedics &Amp; Related Research

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Background Biodegradable interference screws in anterior cruciate ligament (ACL) reconstruction have gained popularity because of their similar or superior fixation strength in comparison to metallic interference screws and because they do not cause imaging artifacts and do not need to be removed. Case Description We report the case of a 23-year-old man who presented with slowly progressive firm swelling of 2 months' duration at the site of the tibial tunnel 3 years after ACL reconstruction using a biodegradable interference screw. After curettage and débridement, the material was sent for histopathologic examination, which was reported as a fibroxanthoma. Literature Review Reported complications are osteolysis around the screw, allergic reaction, sterile abscess formation, ganglion cyst formation, and intraarticular migration.

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“…9,11 Though described as an indolent lesion, local recurrence and rare metastasis to the lung have been reported in the literature. [12][13][14][15] Recurrence of AFX to a deeper location, especially local recurrence of prior auricular lesions to the parotid gland has been described. 16 Local recurrence, vascular invasion, deep-tissue invasion, tumor necrosis, and perineural invasion of AFX are all features that are seen more frequently than metastatic AFX itself.…”

Section: Discussionmentioning

confidence: 99%

CD117 Immunoreactivity in Atypical Fibroxanthoma

Mathew

Schlauder²,

Calder³

et al. 2008

The American Journal of Dermatopathology

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Atypical fibroxanthoma (AFX) is a spindle cell neoplasm of the skin seen typically on sun-damaged skin of the elderly. Though described as a benign entity, local recurrence and distant metastasis have been reported. This study aims to investigate the potential pathogenic role of CD117, the c-kit receptor in AFX. CD117 was detected in 15 of the 16 cases (94%). The percentage of positive cells for CD117 expression among all tumors was approximately 30%. CD117 proved to be a very sensitive marker of AFX. This antibody may be a useful diagnostic adjunct in AFX.

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Atypical Fibroxanthoma and Metastasis to the Lung

Cited by 31 publications

References 10 publications

Spindle Cell Neoplasms Encountered in Dermatologic Surgery: A Review

Spindle Cell Neoplasms Encountered in Dermatologic Surgery: A Review

Case Report: Fibroxanthoma

CD117 Immunoreactivity in Atypical Fibroxanthoma

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