Atypical Fibroxanthoma of the Bulbar Conjunctiva

Shieh, Christine; Daluvoy, Melissa; Ellington, Kenneth S.; Proia, Alan D.

doi:10.1097/ico.0000000000000658

Cited by 17 publications

(8 citation statements)

References 10 publications

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“…Although AFX of the skin is associated with sun exposure or radiation damage in the elderly, now 42% of cases of AFX of the conjunctiva are found in patients under 60 years old without XP. The physical appearance, rapid growth period, and symptoms of irritation and epiphora were similar to previously reported cases [1]. The histologic appearance of our case was different from others in that there was no predominant cell type identified within the lesion.…”

Section: Discussionsupporting

confidence: 60%

“…Some cells of the lesion may contain vacuolated and lipid-containing cytoplasm similar to a xanthoma [4]. Most of the reported cases of conjunctival AFX have been either spindle-cell predominant or pleomorphic with epithelioid and multinucleated giant cells [1]. Here we see some of these features including spindle-shaped cells, multinucleated giant cells and epithelioid cells, without a predominant cell type ( Figure 2B).…”

Section: Discussionmentioning

confidence: 71%

“…Of the five other reported cases, four were found at the limbus, as in our patient [1][2][3][4]. The typical histologic presentation of AFX is spindle, plump, epithelioid and bizarre cells, in various proportions, arranged in haphazard, vaguely fascicular or storiform patterns [4].…”

Section: Discussionmentioning

confidence: 97%

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An Uncommon Case of Atypical Fibroxanthoma of the Bulbar Conjunctiva

Suman¹,

Cossack²,

Rupani³

et al. 2017

J Clin Exp Ophthalmol

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An Atypical Fibroxanthoma (AFX) is a benign skin tumor of mesenchymal origin most commonly found on the sun-exposed or radiation-damaged skin of the elderly. AFX may share many common histologic and clinical characteristics with squamous cell carcinoma and melanoma; however, it is a benign process. Therefore, differentiating between these lesions is important. Differences in histologic features and patterns of immunohistochemical staining for CD68, CD10, cytokeratins, S-100 and Fi-67 may diagnose AFX. The presence of an AFX on the conjunctiva is rare with only five other reported cases. We report a case of AFX that developed in the bulbar conjunctiva near the limbus.

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Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 71%

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An Uncommon Case of Atypical Fibroxanthoma of the Bulbar Conjunctiva

Suman¹,

Cossack²,

Rupani³

et al. 2017

J Clin Exp Ophthalmol

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“…En el diagnóstico diferencial se incluyen la neoplasia escamosa superficial ocular, el carcinoma epidermoide, el granuloma piógeno, el melanoma amelanótico, el melanoma de células fusiformes pleomórfico, el leiomiosarcoma, el histiocitoma fibroso maligno, el histiocitoma fibroso atípico y el schwannoma maligno 7 .…”

Section: Discussionunclassified

Neoplasia inusual escamosa de la superficie ocular y fibroxantoma atípico en córnea y conjuntiva: reporte de caso

Monge-Morera¹,

Chacón²,

Barrantes-Domínguez³

et al. 2023

RMO

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“…Despite its malignant histologic features, it usually behaves in a benign fashion with only rare cases of metastasis. Recurrences have been noted, usually when incompletely excised [5]. Risk factors for this tumor include ultraviolet and radiation exposure.…”

Section: Discussionmentioning

confidence: 99%

Atypical Fibroxanthoma of the Bulbar Conjunctiva: A Unique Case Describing the Pathology, Clinical Presentation, and Management

et al. 2017

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Background/Aims: Atypical fibroxanthoma is an uncommon tumor that usually occurs in the skin of the head and neck of the elderly with significant sun exposure. We describe a unique case featuring a rare ocular surface conjunctival tumor (atypical fibroxanthoma) and provide insight on its characteristic clinical features, surgical management, and histology. Methods: A 71-year-old male fisherman with no pertinent ocular history presented to an academic center with a rapidly enlarging bulbar conjunctival mass in the right perilimbal region for the past several months. The patient underwent surgical excisional biopsy with cryotherapy, adjuvant alcohol, and amniotic membrane transplantation. Results: Pathology specimen illustrated an atypical spindle cell tumor with inflammatory cells, increased mitotic activity, cytologic atypia, and positive diffuse staining with CD163 and CD10 consistent with an atypical fibroxanthoma. Conclusion: Atypical fibroxanthoma is an extremely rare ocular surface tumor that may simulate conjunctival or ocular surface squamous neoplasia. While this lesion typically pursues a benign clinical course, it may recur or rarely metastasize. Thus it should be treated aggressively with excisional biopsy, cryotherapy, absolute alcohol, and/or amniotic membrane transplantation.

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Atypical Fibroxanthoma of the Bulbar Conjunctiva

Abstract: AFX of the conjunctiva is rare, with this being only the fifth example of this neoplasm reported at this site. Complete surgical excision is the most appropriate treatment option.

Cited by 17 publications

References 10 publications

An Uncommon Case of Atypical Fibroxanthoma of the Bulbar Conjunctiva

An Uncommon Case of Atypical Fibroxanthoma of the Bulbar Conjunctiva

Neoplasia inusual escamosa de la superficie ocular y fibroxantoma atípico en córnea y conjuntiva: reporte de caso

Atypical Fibroxanthoma of the Bulbar Conjunctiva: A Unique Case Describing the Pathology, Clinical Presentation, and Management

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