Atypical Fibroxanthoma of the Eyelid and Cheek

Atypical Fibroxanthoma of the Eyelid

“…On the contrary, AFX originates in the dermis and localized excision is adequate for the treatment (1). AFX is superficially located with epidermal ulceration or atrophy of the overlying skin (1). AFX has a predilection for head and neck, whereas MFH commonly involves lower and upper exremities (13).…”

“…It is also difficult to differentiate the neoplasm from squamous cell carcinoma (SCC) (1). SCC stains positively for cytokeratin and epithelial membrane antigen, but does not stain for vimentin and S100 (1). Solar radiation is a definite risk factor for AFX, whereas irradiation is a probable risk factor for the tumor (3).…”

“…Atypical fibroxanthoma (AFX) is an uncommon, fibrohistiocytic tumor of the skin that occurs due to actinic damage in the elderly (1). AFX rarely affects eyelid (2).…”

“…Aggresive recurrence was reported in few AFX cases, despite the benign nature of the tumor (4). Surgical excision with tumor-free borders is curative (1). Malignant fibrous histiocytoma, atypical fibrous histiocytoma, squamous cell carcinoma, sarcoma, dermatofibroma protuberans, and reticulohistiocytoma should be included in differential diagnosis (1,5,6).…”

“…Surgical excision with tumor-free borders is curative (1). Malignant fibrous histiocytoma, atypical fibrous histiocytoma, squamous cell carcinoma, sarcoma, dermatofibroma protuberans, and reticulohistiocytoma should be included in differential diagnosis (1,5,6). As far as we are aware, the present case of AFX is the third one involving the eyelid in the ophthalmic literature (1,2).…”