Atypical Forms of Canine Leishmaniosis

Avaliação hematológica de cães naturalmente infectados por Leishmania (Leishmania) chagasi submetidos a tratamento com antimoniato de meglumina

“…10 The buildup of immune complexes in the kidneys occasionally results in proliferative glomerulonephritis and, in many cases, in interstitial nephritis, which can lead to kidney insufficiency. 3,8,9,11,12,13,14,15 Leishmania also multiply within macrophages in the liver, producing an active chronic hepatitis and, occasionally, hepatomegaly, vomiting, polyuria, polydipsia, anorexia and weight loss. 3,8,11,13,16 Some animals present chronic diarrhea and melena due to the presence of ulcerations in the gastric and intestinal mucosa.…”

“…3,8,9,11,12,13,14,15 Leishmania also multiply within macrophages in the liver, producing an active chronic hepatitis and, occasionally, hepatomegaly, vomiting, polyuria, polydipsia, anorexia and weight loss. 3,8,11,13,16 Some animals present chronic diarrhea and melena due to the presence of ulcerations in the gastric and intestinal mucosa. Enteritis may be a result of direct parasitic damage 11 or a consequence of kidney insufficiency 8,9,17 .…”

“…3,8,11,13,16 Some animals present chronic diarrhea and melena due to the presence of ulcerations in the gastric and intestinal mucosa. Enteritis may be a result of direct parasitic damage 11 or a consequence of kidney insufficiency 8,9,17 . It is possible to observe animals with locomotor, respiratory, cardiac, ophthalmic and neurologic alterations.…”

“…It is possible to observe animals with locomotor, respiratory, cardiac, ophthalmic and neurologic alterations. 11 Dogs with leishmaniasis may present hemorrhagic diatheses such as hematuria, petechia, suffusions, and mainly, epistaxis. Besides the occurrence of ulcerations in the nasal cavity, other causes for the occurrence of hemorrhages include vasculitis, uremia, splenic sequestration of platelets and, occasionally, thrombocytopenia due to aplasia or bone marrow hypoplasia.…”

“…Besides the occurrence of ulcerations in the nasal cavity, other causes for the occurrence of hemorrhages include vasculitis, uremia, splenic sequestration of platelets and, occasionally, thrombocytopenia due to aplasia or bone marrow hypoplasia. 2,11,18,19,20 Pentavalent antimonials, particularly meglumine antimoniate, are the medications of choice in the treatment of human visceral leishmaniasis, and have been used as treatment protocol for dogs. 21 The mechanism of action of these medications have not been completely established, but it is known that they act on the amastigote forms of the parasite, blocking their metabolism by inhibiting the glycolitic activity and the oxidation pathway of fatty acids, being, thus, considered leishmanicidal.…”