Atypical Gianotti-Crosti syndrome

Abstract

We report the case of a male 22-month-old child, with atypical presentation of Gianotti-Crosti syndrome after infection with Epstein-Barr virus.

A Case of Recurrent vaccine-triggered Gianotti–Crosti Syndrome

“…Moreover, previous studies reported an atypical clinical presentation in GCS not associated with hepatitis B, characterized by a polymorphic eruption of erythematous or purpuric papules, vesicles and blisters asymmetrically distributed, frequently coalescing forming large edematous and pruritic lesions [ 16 , 17 ]. Admittedly, this was consistent with our case.…”

Extraoral exanthem revealing Gianotti‐Crosti syndrome in a young child: A case report

“…Nevertheless, the patient did not have any history of drugs intake or family allergy. GCS occurrence was also described after vaccination against polio, influenza, hepatitis B, and DPT vaccine (diphtheria, tetanus, and pertussis) 5,13,16 but the patient did not receive any recent vaccination.…”

Gianotti-Crosti syndrome: exanthema following a vaccination

“…In addition, many GCS cases preceded by vaccination have also been reported. 1,[8][9][10] Vaccines associated with GCS are as following Haemophilus influenza type b (Hib); oral polio; diphtheria, pertussis, and tetanus (DPT); measles, mumps, and rubella (MMR); bacillus Calmette-Guerin (BCG); hepatitis B and A, and Japanese encephalitis. 1,5,9,11 It was reported in the literature that 21 out of 300 GCS cases were associated with vaccination.…”

“…The biopsy may be considered if the skin lesions persist for more than 6 months or GCS cases with atypical presentation and exclude the differential diagnosis in high-risk or immunocompromised patients. 1,2,10 Histopathological features are nonspecific showed parakeratosis of the epidermis, focal spongiosis, mild acanthosis, and psoriasiform epidermal hyperplasia. Perivascular lymphohistiocytic infiltrate with scattered eosinophils and extravasation of erythrocytes in the dermis.…”