Atypical intramuscular lipoma of the tongue

Kacker, Ashutosh; Taskin, Metin

doi:10.1017/s0022215100133146

Cited by 28 publications

(16 citation statements)

References 8 publications

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“…Since the comprehensive review of LS of the tongue from 2005 [2], analyzing a total of 32 cases included in two large series [4,5] and in several case reports [6][7][8][9][10][11][12][13][14][15][16][17][18], only one paper reporting two additional cases has been published [3]. Thus, together with our cases, there are only 40 cases of LS of the tongue reported so far.…”

Section: Discussionmentioning

confidence: 94%

Atypical lipomatous tumors of the tongue: report of six cases

et al. 2009

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The occurrence of liposarcoma in the tongue is rare with only 34 cases published so far. We report six new cases of atypical lipomatous tumor (ALT) of the tongue, and detection of mdm-2 and CDK4 expression by immunohistochemistry and fluorescence in situ hybridization (FISH), respectively, was performed. The series comprised three males and three females, aged 11-78 years. The tumors arose at the lateral side of the tongue, and in one case, multiple tumor nodules were noted. Follow-up information in five cases (range from 4 to 159 months) revealed one local recurrence at 6 months. Microscopically, four cases had features of lipoma-like ALT, whereas two cases displayed patterns of sclerosing ALT. Immunohistochemically, tumor cells revealed expression of vimentin (five of five), S100 (five of five), mdm-2 (three of five), and CDK4 (four of five). Two cases were also examined by FISH; amplification of mdm-2 gene was found in both cases, whereas amplification of CDK4 gene was present in one case only. To the best of our knowledge, this is the third largest series reporting occurrence of ALT in the tongue and the first one where analysis of mdm-2 and CDK4 proteins/genes expression/amplification was performed. Both these markers may be of help in the differential diagnosis of ALT versus lipoma. Although most ALTs of the tongue behave in the nonaggressive fashion, they may recur locally. Based on current data, the term ALT is strongly recommended for tumors occurring in the tongue to prevent inadequate treatment.

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Section: Discussionmentioning

confidence: 94%

Atypical lipomatous tumors of the tongue: report of six cases

et al. 2009

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“…3 8 10 The present case is unique because of its combined multiplicity of origin 11 and its infiltrating nature. 3 10 We also believe that it is the bulkiest lipomatous lesion ever reported within the tongue 12 ; the anatomical and functional significance being macroglossia and dysarthria.…”

Section: Discussionmentioning

confidence: 94%

“…2 Histologically the majority of lipomas are benign and ordinary. 3 Important histological variants of lipomas are spindle cell lipoma, 4 pleomorphic lipoma, 5 angiolipoma, 6 fibrolipoma, 7 and myxoid lipoma. 8 An important differential diagnosis of lipoma is well differentiated lipoma-like liposarcoma.…”

Section: Discussionmentioning

confidence: 99%

Intramuscular lipomatosis of tongue

Stiefmeier

Varghese

Stolzmann

et al. 2002

Postgraduate Medical Journal

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“…Although three of these cases developed on the forehead, the details were not described. We found 19 more cases in the head in the English literature 3–16 . Of these, 16 cases occurred in the oral cavity or around the mouth, one case in the eyelid and two cases 16 within frontal muscles.…”

Section: Discussionmentioning

confidence: 96%

“…We found 19 more cases in the head in the English literature. [3][4][5][6][7][8][9][10][11][12][13][14][15][16] Of these, 16 cases occurred in the oral cavity or around the mouth, one case in the eyelid and two cases 16 within frontal muscles. Infiltrating lipomas associated with temporal muscles are rare.…”

Section: Discussionmentioning

confidence: 99%

Intramuscular lipoma within the temporal muscle

Ban

Kitajima

2002

Int J Dermatology

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A 61-year-old male presented with a 6-month history of a subcutaneous nodule on the left forehead, which had gradually enlarged. He had suffered from headaches from 20 days before the first visit. His medical history included hepatitis C virus infection. He had had no history of trauma in this area. Clinical examination showed a subcutaneous soft nodule, 15 x 15 mm in size, which was adjacent to the left superficial temporal artery (Fig. 1). Though this artery revealed strong pulsation, the nodule had neither pulsation nor tenderness. His headache was localized in the left temporal area. He had no complaints of fever or weakness. Clinically, these features suggested a pseudoaneurysm of the superficial temporal artery. We operated on him under local anesthesia. An incision through the skin and subcutaneous fat exposed a nodule located within the temporal muscle. The fine branches of the superficial temporal artery reached out to the nodule through the muscle. After ligation of the branches, we resected the nodule surrounded by muscular tissue. Histopathology showed the proliferation of mature adipose cells embedded in muscular fibers. These cells had no nuclear pleomorphism or mitoses (Fig. 2). The tumor tissue contained partial fibrosis and some muscular fiber bundles scattered between the adipose cells (Fig. 3). Intramuscular lipoma within the temporal muscle was diagnosed. His headache was reduced after the operation, and he has had no recurrence of the tumor for 16 months. The relationship between the tumor and his headache was unknown.

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Atypical intramuscular lipoma of the tongue

Cited by 28 publications

References 8 publications

Atypical lipomatous tumors of the tongue: report of six cases

Atypical lipomatous tumors of the tongue: report of six cases

Intramuscular lipomatosis of tongue

Intramuscular lipoma within the temporal muscle

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