Atypical L-Type Bovine Spongiform Encephalopathy (L-BSE) Transmission to Cynomolgus Macaques, a Non-Human Primate

Ono, Fumiko; Tase, Naomi; Kurosawa, Asuka; Hiyaoka, Akio; Ohyama, Atsushi; Tezuka, Yukio; Wada, Naomi; Sato, Yuko; Tobiume, Minoru; Hagiwara, Ken'ichi; Yamakawa, Yoshio; Terao, Keiji; Sata, Tetsutaro

doi:10.7883/yoken.64.81

Cited by 46 publications

(2 citation statements)

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“…Macaques have been shown to be susceptible to intracerebral inoculation of vCJD, atypical L-type BSE (L-BSE) and classical BSE (C-BSE) with incubation periods of two to three years and to sCJD with incubation period of around five years [156][157][158]. Classical scrapie was evident in a macaque after a 10-year incubation period, following a high-dose intracerebral inoculation of a classical scrapie isolate [159], illustrating the importance of very long and costly observation periods in this type of study.…”

Section: Transmission Of Cwd To Non-human Primatesmentioning

confidence: 99%

The Zoonotic Potential of Chronic Wasting Disease—A Review

Tranulis

Tryland

2023

Foods

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Prion diseases are transmissible neurodegenerative disorders that affect humans and ruminant species consumed by humans. Ruminant prion diseases include bovine spongiform encephalopathy (BSE) in cattle, scrapie in sheep and goats and chronic wasting disease (CWD) in cervids. In 1996, prions causing BSE were identified as the cause of a new prion disease in humans; variant Creutzfeldt-Jakob disease (vCJD). This sparked a food safety crisis and unprecedented protective measures to reduce human exposure to livestock prions. CWD continues to spread in North America, and now affects free-ranging and/or farmed cervids in 30 US states and four Canadian provinces. The recent discovery in Europe of previously unrecognized CWD strains has further heightened concerns about CWD as a food pathogen. The escalating CWD prevalence in enzootic areas and its appearance in a new species (reindeer) and new geographical locations, increase human exposure and the risk of CWD strain adaptation to humans. No cases of human prion disease caused by CWD have been recorded, and most experimental data suggest that the zoonotic risk of CWD is very low. However, the understanding of these diseases is still incomplete (e.g., origin, transmission properties and ecology), suggesting that precautionary measures should be implemented to minimize human exposure.

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Section: Transmission Of Cwd To Non-human Primatesmentioning

confidence: 99%

The Zoonotic Potential of Chronic Wasting Disease—A Review

Tranulis

Tryland

2023

Foods

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“…BSE is the only known zoonotic animal TSE, causing a variant of Creutzfeldt–Jakob Disease (vCJD) in humans. The zoonotic potential of the atypical forms is unknown, but some laboratory transmission studies indicated the zoonotic potential of the L-BSE form, which appears to be even higher than that of the C-BSE form [ 9 , 10 , 11 , 12 , 13 ]. Additionally, cross-species transmission of C-BSE has been observed in exotic ungulates, cats, and goats in field conditions [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Conventional and State-of-the-Art Detection Methods of Bovine Spongiform Encephalopathy (BSE)

Olech

2023

IJMS

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Bovine spongiform encephalopathy (BSE) is a fatal neurodegenerative disease that belongs to a group of diseases known as transmissible spongiform encephalopathies (TSEs). It is believed that the infectious agent responsible for prion diseases is abnormally folded prion protein (PrPSc), which derives from a normal cellular protein (PrPC), which is a cell surface glycoprotein predominantly expressed in neurons. There are three different types of BSE, the classical BSE (C-type) strain and two atypical strains (H-type and L-type). BSE is primarily a disease of cattle; however, sheep and goats also can be infected with BSE strains and develop a disease clinically and pathogenically indistinguishable from scrapie. Therefore, TSE cases in cattle and small ruminants require discriminatory testing to determine whether the TSE is BSE or scrapie and to discriminate classical BSE from the atypical H- or L-type strains. Many methods have been developed for the detection of BSE and have been reported in numerous studies. Detection of BSE is mainly based on the identification of characteristic lesions or detection of the PrPSc in the brain, often by use of their partial proteinase K resistance properties. The objective of this paper was to summarize the currently available methods, highlight their diagnostic performance, and emphasize the advantages and drawbacks of the application of individual tests.

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Prion Diseases

Belay

Bartz

2014

Viral Infections of Humans

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Atypical L-Type Bovine Spongiform Encephalopathy (L-BSE) Transmission to Cynomolgus Macaques, a Non-Human Primate

Cited by 46 publications

References 0 publications

The Zoonotic Potential of Chronic Wasting Disease—A Review

The Zoonotic Potential of Chronic Wasting Disease—A Review

Conventional and State-of-the-Art Detection Methods of Bovine Spongiform Encephalopathy (BSE)

Prion Diseases

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