2004
DOI: 10.1159/000078475
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Atypical Large Well-Differentiated Hepatocellular Carcinoma with Benign Nature: A New Clinical Entity

Abstract: Based on intranodular hemodynamic studies of nodular lesions associated with liver cirrhosis using computed tomography (CT) during arteriography, CT during arterial portography (CTAP) and angiography under ultrasonography, relatively large hepatocellular nodules with portal perfusion have been depicted. We report 17 such nodules in a total of 663 patients who underwent CTAP. Large well-differentiated hepatocellular carcinomas (HCCs) are characterized by the presence of intranodular portal perfusion even if the… Show more

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Cited by 23 publications
(27 citation statements)
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“…However, at least PAP-US imaging can clearly identify the portal flow feeding nodules, such as DNs and eHCCs, facilitating the differentiation from overt HCC. This technique also provides portal flow supplying nodules, which are basically benign nature nodules [11]. These nodules develop to the overt HCCs at a very slow rate.…”
Section: Discussionmentioning
confidence: 99%
“…However, at least PAP-US imaging can clearly identify the portal flow feeding nodules, such as DNs and eHCCs, facilitating the differentiation from overt HCC. This technique also provides portal flow supplying nodules, which are basically benign nature nodules [11]. These nodules develop to the overt HCCs at a very slow rate.…”
Section: Discussionmentioning
confidence: 99%
“…Usually, there is a correlation between an increase in the tumor diameter and malignancy grade. However, exceptionally, large, well-differentiated, slowly expanding HCC is present [32]. …”
Section: Pathology Of Hepatocellular Carcinomamentioning
confidence: 99%
“…Similarly, any new nodule in a liver with cirrhosis with a diameter of more than 2 cm should always be regarded as very suspicious for HCC, because the benign nature of nodules of this size (a situation not encountered in our series) is rare. 49 …”
Section: The Problem Of Nodules Without Confirmation Ofmentioning
confidence: 99%