Atypical Lesions of the Breast and Lobular Carcinoma in Situ in Pregnancy – Surgeons’ Practice

Abstract

Objective: Approach to precancerous and high-risk breast lesions occurring in pregnancy has received little attention in the literature. We carried out a study to investigate the practice of surgeons in the management of these cases. Materials and Methods:A short survey was sent to surgeons, including a multiple-choice questionnaire about their practice for atypical hyperplasia or lobular carcinoma in situ presenting in each trimester of pregnancy or at time of breastfeeding. Answer options included observation, immediate vacuum biopsy, immediate surgery, surgery in next trimester, surgery after delivery, and surgery after end of breastfeeding; based on the time of presentation.Results: Out of the 671 practitioners invited, 97(14.5 %) responded to the survey. Participants were from 23 countries. Answers showed that management of gestational Atypical Ductal Hyperplasia (ADH) and Lobular Neoplasia (LN) was readily postponed by surgeons in favor of fetus safety while being cautious about risks of conservative management alone. Conclusion:Various methods of treatment are selected by surgeons for managing high-risk breast lesions during pregnancy. In the absence of relevant literature, decision making in a multidisciplinary team would be the best approach in these cases.

Green chemistry and coronavirus

“…Therefore, it is necessary to expeditiously develop new accurate diagnostic methods with high sensitivity to reduce the mortality rate ( Cheng et al, 2020 ). Lung computed tomography (CT) is used as an initial diagnostic procedure in individuals with suspected SARS-CoV-2, however, this technique can solely make possible to assess the patient’s lungs, but cannot easily be applied to monitor the results of therapy ( Ai et al, 2020 ; Çinkooğlu et al, 2020 ). Molecular techniques such as reverse transcription polymerase chain reaction (RT-PCR) are employed to detect the genetic material of the virus in patients with symptoms of active infection.…”