Atypical lipomatous tumor with unusual extensive metaplastic ossification

Abstract

The presence of metaplastic ossification within atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDLPS) is a rare occurrence. When present, bone formation is most often found in association with a dedifferentiated component arising within the primary tumor. It is important for the radiologist not only to recognize the differential diagnosis of a calcified or ossified soft tissue mass but also be aware of the various soft tissue neoplasms, both aggressive and non-aggressive, that may show such features. We report a case of ALT/WDLPS with unusual extensive metaplastic bone formation without an element of dedifferentiated liposarcoma.

Scapular osteochondrolipoma: Imaging features with pathological correlation

“…The condition typically presents as a slow-growing, painless mass in the lower extremities, particularly the thigh. The presence of ossification within a well-differentiated liposarcoma is a rare occurrence (25). MRI usually shows a largely lipomatous mass representing >75% of the lesion and non-adipose components in a thick septa (>2 mm) of irregular aspect or nodular foci (11).…”

Acquired Neurogenic Heterotopic Ossification Following Treatment for ADEM: A Case Report and Literature Review

“…Therefore, we choose the method of revision surgical resection in our case study. (2,3,13,14) Conclusion HO presents multiple diagnostic and therapeutic challenges. Although clinically significant HO occurs infrequently.…”

Neurogenic heterotopic ossification after a stroke: diagnostic and radiological challenges

“…Single-dose radiotherapy or oral nonsteroidal anti-inflammatory drugs such as indometacin have been described to be helpful in the prevention of HO. (3,14,15) Mavrogenis et al advocate resting the affected joint during the acute inflammatory stage of HO, followed by passive ROM exercises and continued mobilisation once the inflammation subsides. (14) Medical therapy and radiotherapy are available for the treatment and prophylaxis of HO, but excisional surgery remains the treatment of choice to restore joint mobility.…”

“…(1, 3,14,15) Due to the extensive mature HO, our patient was managed with only oral analgesics. Surgical management was not indicated for her, as it would not have improved her mobility due to her prior stroke.…”