Atypical localization of colorectal cancer metastasis one case and literature review

Faye, Papa Mamadou; Cagniet, A.; Abousarhan, Fadi

doi:10.1016/j.ijscr.2020.10.073

Cited by 2 publications

(1 citation statement)

References 24 publications

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“…However, he had pedal edema with weight gain and the skin metastasis occupied the lower abdomen and thighs, which might be a result of the blockage of the lymphatic circulation by primary tumor resection and chemotherapy. Some studies have reported that the resection of only the small intestinal or skin metastasis of CRC was associated with good prognosis [ 9 , 12 , 13 ]. However, lymphogenous invasion of the bladder, small intestine, and skin observed in the present case is very rarely reported.…”

Section: Discussion/conclusionmentioning

confidence: 99%

Rare recurrence pattern after complete response to chemotherapy in a patient with rectal cancer: a case report

Nomura,

Tei,

Goto

et al. 2024

surg case rep

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Background Colorectal cancer (CRC) often metastasizes to the liver, lungs, lymph nodes, and peritoneum but rarely to the bladder, small intestine, and skin. We here report the rare metastasis of anal cancer in the left bladder wall, followed by metastases to the small intestine and skin, after abdominoperineal resection and left lateral lymph node dissection with chemotherapy in a patient with clinician Stage IVa disease. Case presentation A 66-year-old man presented with 1-month history of bloody stool and anal pain and diagnosed with clinical Stage IVa anal cancer with lymph node and liver metastases (cT3, N3 [#263L], M1a [H1]). Systemic chemotherapy led to clinical complete response (CR) for the liver metastasis and clinical near-CR for the primary tumor. Robot-assisted laparoscopic perineal rectal resection and left-sided lymph node dissection were performed. Computed tomography during 18-month postoperative follow-up identified a mass in the left bladder wall, which was biopsied with transurethral resection, was confirmed as recurrent anal cancer by histopathologic evaluation. After two cycles of systemic chemotherapy, partial resection of the small intestine was performed due to bowel obstruction not responding to conservative therapy. The histopathologic evaluation revealed lymphogenous invasion of the muscularis mucosa and subserosa of all sections. Ten months after the first surgery for bowel obstruction and two months before another surgery for obstruction of the small intestine, skin nodules extending from the lower abdomen to the thighs were observed. The histopathologic evaluation of the skin biopsy specimen collected at the time of surgery for small bowel obstructions led to the diagnosis of skin metastasis of anal cancer. Although panitumumab was administered after surgery, the patient died seven months after the diagnosis of skin metastasis. Conclusions This case illustrates the rare presentation of clinical Stage IVa anal cancer metastasizing to the bladder wall, small intestine, and skin several years after CR to chemotherapy.

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Section: Discussion/conclusionmentioning

confidence: 99%

Rare recurrence pattern after complete response to chemotherapy in a patient with rectal cancer: a case report

Nomura,

Tei,

Goto

et al. 2024

surg case rep

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Cutaneous Limb Metastasis of Colorectal Cancer Misdiagnosed as Zoster Infection

Albandak¹,

Albandak²,

Abdallah³

et al. 2023

Cureus

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Cutaneous metastasis is a rare manifestation of internal malignancies. It usually occurs with the later progression of the disease and is associated with a poor prognosis. Common culprits of skin metastasis include lung cancer, melanoma, and colorectal cancer in men and breast cancer, colorectal cancer, and melanoma in women. Given these points, there is a low rate of cutaneous metastasis of colorectal cancer. When present, the most common sites include the abdominal wall and, less frequently, the face and the scalp. Rarely there is cutaneous metastasis to the upper extremity. Herein, we report the case of a female patient in her 50s who presented with a maculopapular rash of the right upper limb four years after her initial diagnosis of colonic adenocarcinoma. However, because of this rare manifestation, she was initially misdiagnosed with more common causes of a maculopapular rash. After a period of no improvement with preliminary treatment, a biopsy with immunohistochemical staining was undertaken, and the specimen stained positive for CK20 and CDX2, confirming metastatic colorectal malignancy. Skin lesions that are not responding to conventional therapy and those which have bizarre presentations can be a harbinger of internal malignancy and should be considered in the differential.

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Atypical localization of colorectal cancer metastasis one case and literature review

Cited by 2 publications

References 24 publications

Rare recurrence pattern after complete response to chemotherapy in a patient with rectal cancer: a case report

Rare recurrence pattern after complete response to chemotherapy in a patient with rectal cancer: a case report

Cutaneous Limb Metastasis of Colorectal Cancer Misdiagnosed as Zoster Infection

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