Atypical lymphocytes associated with monkeypox virus infection

Monkeypox virus: A new etiology for reactive lymphocytes in peripheral blood

“…To our knowledge, this is the second reported case study of possible monkeypox associated atypical/reactive lymphocytes in PB. Our findings are similar to those reported recently in which patients had no coinfections with HSV1/2 or varicella-zoster virus [3]. Awareness of this finding would facilitate early diagnosis by confirmatory molecular testing and prompt future studies for pathophysiology of the disease.…”

Transient decrease in T cells and atypical lymphocyte proliferation after the onset of mpox

“…1 Some viral infectious diseases are associated with either lymphocytosis or lymphocytopenia, and atypical lymphocytes are well recognized as a feature of primary viral infections; primary infections with Epstein-Barr virus (EBV) or cytomegalovirus (CMV) result in increased atypical lymphocytes with lymphocytosis, whereas acute HIV infection often presents with lymphocytopenia. 2 Atypical lymphocytes were also observed in mpox (disease caused by the monkeypox virus), 3,4 an epidemic among men who have sex with men (MSM) in Europe and the United States since 2022, 5,6 and were reported in the early 20th century in smallpox, 7 a related disease caused by the variola virus, a virus of the same genus Orthopoxvirus.…”

Atypical lymphocytes—From chickenpox to monkey pox

“…Monkeypox, now renamed mpox, is the most recently recognized viral cause. 1 The upper two images (all images Â100 objective) show the blood film of 2-week-old, term baby born to a G1P1 mother, presenting with a skin rash that started on day 10 of life. 2 The rash was pustular/ vesicular on an erythematous base, affecting the limbs, buttocks, scalp, forehead, and dorsum of the hands and palms, and sparing mucus membranes.…”

“…Chickenpox, due to the varicella/zoster virus, is a well‐established cause. Monkeypox, now renamed mpox, is the most recently recognized viral cause 1 …”