Atypical Mycobacterium infections of the upper extremity

Noguchi, Masataka; Taniwaki, Yoshimichi; Tani, Tohru

doi:10.1007/s00402-005-0042-0

Cited by 18 publications

(23 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Rifampicin has been also used effectively in isolated cases, either alone [30,62] or in combination with other antibiotics [37,38,43,44,51] , antimycobacterials [30,35] , antibiotics plus antimycobacterials [19,42,45,48] , and with antimicrobials plus surgery [30,31,49,50,[63][64][65] . Rifabutin has been administered successfully with clarithromycin [51] .…”

Section: Antimycobacterial Agentsmentioning

confidence: 99%

“…It has rarely been used as monotherapy, but in combination with rifampicin or with other antimycobacterials [3,15] , with antibiotics [17,46,47,53,54] or a combination of antibiotics and antimycobacterials [29,42,45] and with surgery plus antimicrobacterials [26,49,50,63] .…”

Section: Antimycobacterial Agentsmentioning

confidence: 99%

“…They have been used with various results, either as the sole therapy [7,13,14,67] or in combination with antimicrobials [6,9,13,26,30,31,49,50,61,[63][64][65][68][69][70][71] , before or after surgical treatment.…”

Section: Surgical Treatmentmentioning

confidence: 99%

See 2 more Smart Citations

Treatment ofMycobacterium marinumcutaneous infections

Rallis

Koumantaki-Mathioudaki

2007

Expert Opinion on Pharmacotherapy

119

101

View full text Add to dashboard Cite

Mycobacterium marinum is a non-tuberculous mycobacterium found in non-chlorinated water, with worldwide prevalence. It is the most common atypical Mycobacterium that causes opportunistic infection in humans. It presents as a solitary, red-to-violaceous plaque or nodule with an overlying crust or verrucous surface, or as inflammatory nodules or abscesses, usually in a sporotrichotic type of distribution. Deep infections may also occur. Although diagnosis is confirmed by isolation and identification of the organism in practice diagnosis remains largely presumptive based on clinicohistological features and the response to treatment. Polymerase chain reaction allows the routine early detection of the organism from a biopsy specimen. In the near future, it seems possible that histopathological examination might be greatly assisted by the rapidly improving possibilities with in vivo imaging. There have been many therapeutic modalities used effectively in the treatment of M. marinum infections. Spontaneous remission has also been reported in untreated infections and in immunocompetent hosts. However, there is no proven treatment of choice because M. marinum is naturally multi-drug resistant species and treatment is based primarily on the personal experience and preference of individual investigators, without the benefit of large studies. In superficial cutaneous infections minocycline, clarithromycin, doxycycline and trimethoprim-sulfamethoxazole as monotherapy are effective treatment options, but drug resistance varies and thereby combination therapy usually of two drugs may be required. Ciprofloxacin has shown considerable effectiveness. In cases of severe infections, including those with a sporotrichoid distribution pattern, a combination of rifampicin and ethambutol seems to be the recommended regimen. The use of isoniazid, streptomycin and pyrazinamide as empirical treatment options should be avoided. Surgical treatment is not usually recommended and must be cautiously applied. Cryotherapy, X-ray therapy, electrodesiccation, photodynamic therapy and local hyperthermic therapy have been reported as effective therapeutic alternatives. M. marinum infection should always be included in the differential diagnosis of all cases with poor-healing wounds in upper extremities and a history of exposure to aquariums.

show abstract

Section: Antimycobacterial Agentsmentioning

confidence: 99%

Section: Antimycobacterial Agentsmentioning

confidence: 99%

See 1 more Smart Citation

Treatment ofMycobacterium marinumcutaneous infections

Rallis

Koumantaki-Mathioudaki

2007

Expert Opinion on Pharmacotherapy

119

101

View full text Add to dashboard Cite

show abstract

“…1,3,8,21 However, there is a lack of consensus regarding both the drugs of choice and the duration of treatment. Zenone et al and others 1,3,8 suggested empirically beginning antimicrobial therapy in the immediate postoperative period if there is high clinical suspicion of mycobacterial infection.…”

Section: Discussionmentioning

confidence: 99%

Radical Surgical Debridement Alone for Treatment of Carpal Tunnel Syndrome Caused by Mycobacterium Avium Complex Flexor Tenosynovitis: Case Report

Moores¹,

Grewal²

2011

The Journal of Hand Surgery

View full text Add to dashboard Cite

“…More than ten species have been described to cause tenosynovitis [24], the most common being M. marinum and M. kansasii. Most infections were related to exposure to contaminated water sources, trauma, or iatrogenic procedures such as steroid injections [17,24]. Infections with M. Chelonae have also been reported to occur without an inciting event [14].…”

Section: Discussionmentioning

confidence: 99%

Mycobacterium Chelonae Infection Following Silicone Arthroplasty of the Metacarpophalngeal Joints: A Case Report

Iordache

Daneman

Axelrod

2008

Hand (New York, N,Y.)

View full text Add to dashboard Cite

We present a case of infection caused by an uncommon pathogen, Mycobacterium chelonae, in a patient that underwent Swanson silicone arthroplasty of the metacarpophalangeal joints for rheumatoid arthritis. This is the first report of an infection caused by nontuberculous Mycobacteria in flexible silicone implants in the hand. The patient was successfully treated with implant removal, debridement, and antimicrobials tailored to the results of in vitro susceptibility testing.

show abstract

Atypical Mycobacterium infections of the upper extremity

Abstract: Surgical debridement and appropriate mycobacterial culture or PCR method are critical to enable diagnosis and appropriate management.

Cited by 18 publications

References 14 publications

Treatment ofMycobacterium marinumcutaneous infections

Treatment ofMycobacterium marinumcutaneous infections

Radical Surgical Debridement Alone for Treatment of Carpal Tunnel Syndrome Caused by Mycobacterium Avium Complex Flexor Tenosynovitis: Case Report

Mycobacterium Chelonae Infection Following Silicone Arthroplasty of the Metacarpophalngeal Joints: A Case Report

Contact Info

Product

Resources

About