2015
DOI: 10.1097/pgp.0000000000000128
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Atypical Placental Site Nodule (APSN) and Association With Malignant Gestational Trophoblastic Disease; A Clinicopathologic Study of 21 Cases

Abstract: The WHO Classification of Gestational Trophoblastic Tumors classifies placental site nodule (PSN) as a benign tumor-like trophoblastic neoplasm. Cases of PSN with atypical features were described [atypical placental site nodule (APSN)] and we started registering APSN in our unit in 2005. The aim of this study is to present our initial experience with these lesions. The Trophoblastic Disease Unit database was searched to identify all patients who were either referred with, or on review were diagnosed with, APSN… Show more

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Cited by 80 publications
(52 citation statements)
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“…ETT may coexist with choriocarcinoma or PSTT [10][11][12]. Emerging data indicate that atypical placental site nodules (APSN) can co-exist and/or preceded ETT and PSTT, suggesting that at least APSN cannot be regarded as benign [13].…”
Section: Epithelioid Trophoblastic Tumormentioning
confidence: 99%
“…ETT may coexist with choriocarcinoma or PSTT [10][11][12]. Emerging data indicate that atypical placental site nodules (APSN) can co-exist and/or preceded ETT and PSTT, suggesting that at least APSN cannot be regarded as benign [13].…”
Section: Epithelioid Trophoblastic Tumormentioning
confidence: 99%
“…56 In the most recent series of 21 APSNs, 3 patients had concurrent or subsequent malignant trophoblastic tumors: 1 patient had concurrent APSN and PSTT, 1 patient developed PSTT after 16 months, and 1 patient received a diagnosis of ETT 6 months after the diagnosis of APSN. 57 Therefore, it is clinically relevant that patients with APSN should undergo imaging studies to rule out underlying mass lesion and require clinical follow-up, including serum hCG measurement.…”
Section: Differential Diagnosismentioning
confidence: 99%
“…The histologic features of the APSN were intermediate between PSN and PSTT/ETT, with lesions larger than the usual PSN, which rarely exceed 4 mm. APSNs also had increased cellularity, mild atypia, and an increased ki‐67 index compared to usual PSN .…”
Section: Lesions Of Extravillous Trophoblastmentioning
confidence: 96%
“…). A potential pitfall, although rare, are atypical placental site nodules (APSN) . On one series, 3/21 lesions termed APSN were associated with GTD on follow‐up, developing into either PSTT or ETT.…”
Section: Lesions Of Extravillous Trophoblastmentioning
confidence: 99%