Atypical plasma lipid profiles in leukemia

Iqbal, Areeb; Zaid, Muhammad; Munir, Rimsha; Usman, Hina; Kalbacher, Hubert; Scandiuzzi, Lisa; Zaidi, Nousheen

doi:10.1016/j.cca.2015.11.003

Cited by 5 publications

(4 citation statements)

References 40 publications

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“…In the present study, we found that the serum Apo A-1 and Apo B levels were positively associated with OS in AML patients. Significant reductions in serum LDL levels have also been reported in AML patients (17). The results of these studies are generally in good agreement with the findings of our analysis.…”

Section: Comparison Of the Prognostic Factorssupporting

confidence: 92%

Lipid profile as a novel prognostic predictor for patients with acute myeloid leukemia

et al. 2023

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PurposeThis study investigated the relationship between serum lipid levels and clinical outcomes in acute myeloid leukemia (AML) by establishing a predictive risk classification model.MethodA total of 214 AML patients who were pathologically diagnosed and treated with standard induction chemotherapy at Sun Yat-Sen University Cancer Center were included. The patients were randomly divided into the training (n = 107) and validation (n=107) cohorts. Univariate and multivariate Cox analyses were used to assess the value of triglyceride (TG), Apolipoprotein B (Apo B), Apo Apolipoprotein A-I (Apo A-I), cholesterol (CHO), and high-density lipoprotein (HDL) as prognostic factors for AML.ResultsAfter a series of data analyses, a five-factor model was established to divide the patients into high- and low-risk groups. Kaplan-Meier survival analysis showed that the high-risk group had a poor prognosis (P<0.05). The area under the curve of the novel model for five-year OS was 0.737. A nomogram was constructed to integrate the model with age and the 2017 ELN cytogenetic classification, with the merged model showing improved accuracy with an area under the curve of 0.987 for five-year OS.ConclusionA novel model was constructed using a combination of the serum lipid profile and clinical characteristics of AML patients to enhance the predictive accuracy of clinical outcomes. The nomogram used the lipid profile which is routinely tested in clinical blood biochemistry and showed both specific prognostic and therapeutic potential.

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Section: Comparison Of the Prognostic Factorssupporting

confidence: 92%

Lipid profile as a novel prognostic predictor for patients with acute myeloid leukemia

et al. 2023

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“…Iqbal et al 5 showed lower mean CH, LDL-C, HDL-C and albumin in cancer in comparison to non-cancer patients; they were also significantly lower in those with metastatic solid tumors. They also found that TG was lower in non-metastatic disease and no association was observed between LDL-C, HDL-C and TG and the stage of disease 5 . In the current study, TG abnormalities were observed mainly in metastatic group, however without statistical differences in the prevalence rate.…”

Section: Discussionmentioning

confidence: 93%

“…Malignancy also seems to influence CH levels. Hypocholesterolemia has been observed in various forms of cancer at diagnosis, particularly in hematological ones 5,31 . Low CH has been associated with increased mortality from cancer in several observational and clinical studies 32 .…”

Section: Discussionmentioning

confidence: 99%

“…Increases in lipid, lipoprotein and glucose profile and catabolism of protein have been described in these patients and are associated with inflammatory response due to the presence of the tumor, infectious or anticancer therapy complications. This condition has been described as anorexia-cachexia syndrome 1,2 , which is generated by elevated pro-inflammatory cytokines levels [3][4][5] . It is believed that inflammatory response is an important factor in the inter individual variability of response and toxic effects of cancer chemotherapy 6 .…”

Section: Introductionmentioning

confidence: 99%

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Low Levels of High-density Lipoprotein in Patients with Pediatric Cancer at Diagnosis

Garófolo

Maia-Lemos

2020

Rev. Brasileira.De.Cancerologia

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Introduction: Cancer patients have metabolic imbalances due to the disease, treatment and their complications. Increases in triglycerides and glucose profile and catabolism of protein have been described and are associated with inflammatory response as result of the tumor activity or necrosis. Objective: To evaluate the blood lipid, lipoproteins, glucose and albumin levels in pediatric cancer patients at diagnosis. Method: Observational cross-sectional study. The inclusion criteria were children and adolescents with newly diagnosed malignancies and blood analysis results. The exclusion criteria were: previous anticancer therapy or surgical treatment, blood sample not collected and patients who refused to participate in the study. Results: It were evaluated 81 children and adolescents with newly diagnosed malignancies. There was decrease of 56% and 41% of high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG), 14% and 10% of albumin and glucose, and 10% and 7.6% of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C), respectively, for the patients. HDL-C showed statistical differences between solid and hematological cancer patients (p < 0.05). The means and medians of albumin, glucose, HDL-C and TG demonstrated that hematological patients are more prone to metabolic disturbances. HDL-C in this group was 24 ± 12 versus 40 ± 15mg/dl in other cancers. Conclusion: The primary result found in the present study was in HDL-C, mainly in patients with hematological and metastatic cancer. These disturbances could be associated with cancer-related acute inflammatory response.

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Leukemia cells display lower levels of intracellular cholesterol irrespective of the exogenous cholesterol availability

Usman

Ameer

Munir

et al. 2016

Clinica Chimica Acta

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Atypical plasma lipid profiles in leukemia

Cited by 5 publications

References 40 publications

Lipid profile as a novel prognostic predictor for patients with acute myeloid leukemia

Lipid profile as a novel prognostic predictor for patients with acute myeloid leukemia

Low Levels of High-density Lipoprotein in Patients with Pediatric Cancer at Diagnosis

Leukemia cells display lower levels of intracellular cholesterol irrespective of the exogenous cholesterol availability

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