Atypical presentation and localization of granulosa cell tumor—A case report and review of the literature

Abstract

Introduction: Extraovarian granulosa cell tumor (GCT) is a very uncommon tumor, assumed to arise from the ectopic gonadal tissue along the embryonal route of the genital ridge. Case Report: We report the case of a 25 year-old woman who was presented at the emergency unit with a severe abdominal pain focused on the left iliac fossa. The patient had delivered normally 2 months before. An ovarian mass of 79 × 67 × 89 mm was shown in vaginal ultrasound as well as at the abdominal scan. Exploratory laparoscopy was performed and a torsion of the fallopian tube and an hematosalpinges was visualized. Re-vascularisation was not achieved and a left salpingectomy took place. The immuno-histopathology report revealed an extraovarian GCT deriving from the fimbriae of the tube. Follow-up surgery was discussed. The case is presented for its rarity.

An unusual presentation of a granulosa cell tumor in broad ligament: morphological features and close differential

“…Extraovarian granulosa cell tumor (e GCTs) are very uncommon tumors. Amongst all the cases published so far, most of the eGCTs have been reported in various parts in the retroperitoneum [2][3][4][5][6][7][8], followed by broad ligament [9][10][11], fallopian tube [12,13], mesentery [14] and even adrenals [15].…”

“…It is noteworthy that a diagnosis of eGCT should be carried out only after excluding any previous history of GCT of the ovary [1]. Amongst all the cases published so far, most of the eGCTs have been reported in various parts of the retroperitoneum [2][3][4][5][6][7][8], followed by broad ligament [9][10][11], fallopian tube [12,13], mesentery [14] and even adrenals [15]. Interestingly, eGCTs share a significant overlap topographically, morphologically, and immunohistochemically with another very rare tumor, Female Adnexal Tumor of probable Wolffian Origin (FATWO), which comes across as its closest differential [9,10], especially amongst the broad ligament tumors.…”