Atypical presentation of invasive meningococcal disease caused by serogroup W meningococci

Stinson, Crystal; Burman, Cynthia; Presa, Jessica; Abalos, Maria Gabriela

doi:10.1017/s0950268819002152

Cited by 25 publications

(20 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Approximately 1.2 million IMD cases occur annually worldwide, and it is associated with a case-fatality rate (CFR) of approximately 10% [ 1 , 7 ]. However, the CFR may increase significantly in cases of inadequate or delayed diagnosis and treatment, and varies according to serogroup [ 8 , 9 ]. Atypical clinical presentation has been observed for various serogroups (e.g.…”

Section: Introductionmentioning

confidence: 99%

Systematic review of invasive meningococcal disease epidemiology in the Eastern Mediterranean and North Africa region

Dogu

Oordt-Speets²,

Bruijn³

et al. 2021

BMC Infect Dis

View full text Add to dashboard Cite

Background Invasive meningococcal disease (IMD) represents a global health burden. However, its epidemiology in the Eastern Mediterranean (EM) and North Africa (NA) regions is currently not well understood. This review had four key objectives: to describe asymptomatic meningococcal carriage, IMD epidemiology (e.g. serogroup prevalence, case-fatality rates [CFRs]), IMD presentation and management (e.g. clinical diagnosis, antibiotic treatments) and economic impact and evaluation (including health technology assessment [HTA] recommendations) in EM and NA. Methods A systematic literature search (MEDLINE and EMBASE) was conducted (January 2000 to February 2021). Search strings included meningococcal disease and the regions/countries of interest. Identified publications were screened sequentially by title/abstract, followed by screening of the full-text article; articles were also assessed on methodological quality. Literature reviews, genetic sequencing or diagnostic accuracy studies, or other non-pertinent publication type were excluded. An additional grey literature search (non-peer-reviewed sources; start date January 2000) was conducted to the end of April 2019. Results Of the 1745 publications identified, 79 were eligible for the final analysis (n = 61 for EM and n = 19 for NA; one study was relevant to both). Asymptomatic meningococcal carriage rates were 0–33% in risk groups (e.g. military personnel, pilgrims) in EM (no data in NA). In terms of epidemiology, serogroups A, B and W were most prevalent in EM compared with serogroups B and C in NA. IMD incidence was 0–20.5/100,000 in EM and 0.1–3.75/100,000 in NA (reported by 7/15 countries in EM and 3/5 countries in NA). CFRs were heterogenous across the EM, ranging from 0 to 57.9%, but were generally lower than 50%. Limited NA data showed a CFR of 0–50%. Data were also limited in terms of IMD presentation and management, particularly relating to clinical diagnosis/antibiotic treatment. No economic evaluation or HTA studies were found. Conclusions High-risk groups remain a significant reservoir of asymptomatic meningococcal carriage. It is probable that inadequacies in national surveillance systems have contributed to the gaps identified. There is consequently a pressing need to improve national surveillance systems in order to estimate the true burden of IMD and guide appropriate prevention and control programmes in these regions.

show abstract

Section: Introductionmentioning

confidence: 99%

Systematic review of invasive meningococcal disease epidemiology in the Eastern Mediterranean and North Africa region

Dogu

Oordt-Speets²,

Bruijn³

et al. 2021

BMC Infect Dis

View full text Add to dashboard Cite

show abstract

“…The N. meningitidis clone is caused by a single introduction event. In Victoria, this event undergoes an extensive endemic transmission [1,2] .…”

Section: Figure 3 a Complete Resolution Of Abscess Discussionmentioning

confidence: 99%

A Rare Case of Cervical Epidural Abscess Post Posterior Cervical Laminotomy with Isolation of Neisseria Meningitides Bacteria

Ammar Najim Abood

2021

Indian Journal of Forensic Medicine & Toxicology

View full text Add to dashboard Cite

Spinal epidural abscess is a rare condition, although it requires an urgent surgery to decrease the pressure on the epidural sac in addition to the other structures of the spinal cannel cord and nerve roots.A 29 years old female entered the clinic with large neck swelling. She also had a history of headache with neck pain, both arm paresthesia with mild fever. Her MRI showed an epidural collection at level of cervical 5 to cervical 7 compressing the dural sac narrowing the spinal cannel and extending to the paraspinal intramuscular area in the neck.She had undergone a surgery with a 2cm mid line incision above the swelling mass in order to suck out the pus. In addition, the intermittent Valsalva maneuver was performed to enhance the epidural pus gat out. The culture and sensitivity test to pus indicated a Neisseria meningitides bacterial growth. Penicillin G and cefotaxime as antibiotics were prescribed. Improvement occurred within 2 weeks.Although rare, the isolated Neisseria meningitides spinal epidural abscess requires an urgent treatment through evacuating and decompressing. Spondylodiscitis or collapse may occur, therefore, a surgery for spine correction may be needed, fellow up is recommended in all forms of epidural abscesses.

show abstract

“…The incidence of MenW-IMD has displayed an increasing trend over the last decade in European countries, in particular in the Netherlands, Sweden, the UK, Switzerland [41], but also in Spain [42] and France [43]. In addition, while the prevalence of MenB and MenW invasive isolates in Europe differed substantially (~51% versus ~19%, respectively, in 2018), they accounted for a similar proportion of fatal IMD cases (36% versus 31%) [21], mainly due to the circulation of hypervirulent MenW strains belonging to the cc11 clonal complex [44,45], also observed for other serogroups (e.g., MenC in the Tuscany outbreak). An increase in the proportion of MenY-IMD has also occurred in certain European regions since 2010 [1,21,46].…”

Section: Menacwy Vaccinationmentioning

confidence: 99%

Evolving strategies for meningococcal vaccination in Europe: Overview and key determinants for current and future considerations

Martinón-Torres

Taha

Knuf³

et al. 2021

Pathogens and Global Health

View full text Add to dashboard Cite

Invasive meningococcal disease (IMD) is a life-threatening, unpredictable condition. Vaccines are available against 5 of the 6 meningococcal serogroups (Men) accounting for nearly all IMD cases worldwide; conjugate monovalent MenC, quadrivalent MenACWY, and protein-based MenB vaccines are commonly used. We provide a comprehensive overview of the evolution of meningococcal vaccination strategies employed in national immunization programmes (NIPs) and their impact on IMD incidence in Europe. A more in-depth description is given for several countries: the United Kingdom (UK), the Netherlands, Greece, Italy, and Ireland. We searched European health authorities' websites and PubMed. Various vaccines and immunization schedules are used in 21 NIPs. Most countries implement MenC vaccination in infants, MenACWY in adolescents, and a growing number, MenB in infants. Only Malta has introduced MenACWY vaccination in infants, and several countries reimburse immunization of toddlers. The UK, Italy, Ireland, Malta, Andorra, and San Marino recommend MenB vaccination in infants and MenACWY vaccination in adolescents, targeting the most prevalent serogroups in the most impacted age groups. Main factors determining new vaccination strategies are fluctuating IMD epidemiology, ease of vaccine implementation, ability to induce herd protection, favorable benefit-risk balance, and acceptable cost-effectiveness. Since 1999, when the UK introduced MenC vaccination, the reduction in IMD incidence has been gradually enhanced as other countries adopted routine meningococcal vaccinations. Meningococcal vaccination strategies in each country are continually adapted to regional epidemiology and national healthcare priorities. Future strategies may include broader coverage vaccines when available (e.g., MenABCWY, MenACWY), depending on prevailing epidemiology.

show abstract

Atypical presentation of invasive meningococcal disease caused by serogroup W meningococci

Cited by 25 publications

References 41 publications

Systematic review of invasive meningococcal disease epidemiology in the Eastern Mediterranean and North Africa region

Systematic review of invasive meningococcal disease epidemiology in the Eastern Mediterranean and North Africa region

A Rare Case of Cervical Epidural Abscess Post Posterior Cervical Laminotomy with Isolation of Neisseria Meningitides Bacteria

Evolving strategies for meningococcal vaccination in Europe: Overview and key determinants for current and future considerations

Contact Info

Product

Resources

About