Atypical Small Acinar Proliferation in the Prostate

Meiers, Isabelle; Kahane, Hillel; Bostwick, David G.

doi:10.1097/pcr.0b013e31817e18fa

Cited by 4 publications

(7 citation statements)

References 31 publications

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“…25 Whereas several previous studies concluded that intraluminal crystalloid is an uncommon feature found in ASAP cases and is not associated with the incidence of prostate adenocarcinoma. 6,12 Mitotic features were not found in all cases in this retrospective study. According to references, mitosis can be found in benign lesion, especially those adjacent to infarction.…”

Section: Discussioncontrasting

confidence: 54%

“…Other studies state that hyperchromatic nuclei are more found in cases of the atypical prostate gland, including ASAP, compared to minimal carcinoma. 12,13 In this retrospective study, amphophilic cytoplasm was found to be more abundant in the prostate adenocarcinoma group than in the benign lesion group, although this was not statistically significant. This is similar to other studies which show that amphophilic cytoplasm is more commonly found in malignant prostate glands than in benign lesion glands.…”

Section: Discussioncontrasting

confidence: 53%

“…9,16,17 Nuclei chromatin in ASAP from previous studies was shown to be hyperchromatic. 9,12 In this study, both the benign lesion and malignant prostate groups showed 1 case with hyperchromatic nuclei and no statistically significant results were obtained. Other studies state that hyperchromatic nuclei are more found in cases of the atypical prostate gland, including ASAP, compared to minimal carcinoma.…”

Section: Discussionmentioning

confidence: 52%

“…10 Stroma infiltration is a major criteria for diagnosing prostate adenocarcinoma. 11 Study by Meiers and Sade et al 6,12 stated that infiltrative growth patterns were often found in patients with ASAP (68-75%), although in that study no statistically significant differences were found between the benign lesion and malignant prostate groups. That study is similar to this retrospective study because 31 cases out of 49 atypical prostate glands including ASAP showed stromal infiltration, that is 16 cases (51.6%) among them in the prostate adenocarcinoma group.…”

Section: Discussionmentioning

confidence: 89%

“…This is similar to Sade et al 6 study that showed nuclei enlargement can be found in 22% of benign lesion cases. While the study of Meiers and Iczowski et al 12,13 showed that mild nuclei enlargement can be found in ASAP and moderate nuclei enlargement is found in minimal carcinoma. Although nuclei enlargement is often associated with the diagnosis of prostate adenocarcinoma but the sensitivity is low and other diagnostic criteria must be considered.…”

Section: Discussionmentioning

confidence: 95%

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Relationship between Clinicohistomorphology Profile of Atypical Prostate Gland and Diagnosis Benign Lesion or Prostate Adenocarcinoma

MZ¹,

B²

2023

MPI

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BackgroundAtypical prostate gland especially atypical small acinar proliferation (ASAP) is a histopathological diagnosis that requires a follow-up biopsy 3-6 months after the first biopsy, because 17-60% of cases potentially to be malignant. The varied clinical and histomorphological characteristics of the atypical prostate gland make it difficult to confirm the final diagnosis as a benign lesion or prostate adenocarcinoma. This study aims to describe clinicohistomorphological cases of atypical prostate gland at Anatomical Pathology Department FKUI/RSCM and to identify histomorphological features of the atypical prostate gland as benign lesions or prostate adenocarcinoma on immunohistochemistry diagnosis.MethodsA histopathological investigation of prostate gland cases with atypical nuclei was carried out in 2011-2021 from archives of Anatomical Pathology Department FKUI/RSCM. Clinical and histomorphological characteristics were assessed and categorized into benign lesions or prostate adenocarcinoma based on immunohistochemistry appearance.ResultsThere were 109 cases of atypical prostate gland, 49 of which met the inclusion and exclusion criteria and could be analyzed. Corpora amylacea was found in 11 cases (84.6%) in the benign lesion group, statistically significant (p-value 0.005). Intraluminal crystalloids were found in 4 cases (100%) in the prostate adenocarcinoma group with p-value 0.050, close to significant. Other clinicohistomorphological characteristics did not show a significant relationship both in benign lesions and prostate adenocarcinoma groups (p-value 0.05).Conclusion On histopathological examination of the atypical prostate gland that is difficult to re-biopsy, the discovery of corpora amylacea may lead to the diagnosis of a benign lesion, while the discovery of intraluminal crystalloids may lead to the diagnosis of prostate adenocarcinoma. The diagnosis must be supported by immunohistochemistry characteristics.

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Section: Discussioncontrasting

confidence: 54%

Section: Discussioncontrasting

confidence: 53%