Atypical spinal tuberculosis mimicking malignancy: the utility of multimodality imaging evaluation

Tan, Timothy Shao Ern; Mahmood, Rameysh Danovani

doi:10.1136/postgradmedj-2020-138350

Postgraduate Medical Journal

2020

DOI: 10.1136/postgradmedj-2020-138350

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Atypical spinal tuberculosis mimicking malignancy: the utility of multimodality imaging evaluation

Timothy Shao Ern Tan

Rameysh Danovani Mahmood

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2024

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Cited by 2 publications

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Surgical treatment of spinal tuberculosis: an updated review

Gan,

Zhang,

Tang

et al. 2024

Eur J Med Res

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Tuberculosis (TB) is a worldwide disease which seriously affects the global public health. Spinal TB is the most common extra-pulmonary TB and may cause vertebral bone destruction, collapse, kyphosis and even paralysis. Anti-TB chemotherapy is considered the cornerstone treatment of spinal TB and surgery is often required for patients with severe kyphosis, impaired neurological function or spinal instability. Debridement of TB lesions, bone grafting and internal fixation are the key procedures of spinal TB surgery. However, the selection of surgical approach, the extent of TB lesion debridement, the choice of bone graft materials, and the method and extent of internal fixation are all remain controversy. The aim of this updated review is to evaluate current literature for advances in management of spinal TB, with particular focus on surgical techniques.

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Surgical treatment of spinal tuberculosis: an updated review

Gan,

Zhang,

Tang

et al. 2024

Eur J Med Res

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Prognostic nutritional index and naples prognostic score as biomarkers for the prognosis of incisional wound healing after thoracolumbar tuberculosis surgery

Xiong,

Qin,

Zhang

et al. 2024

PLoS ONE

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Objectives This study aimed to evaluate and compare the clinical predictive value of prognostic nutritional index (PNI) and naples prognostic score (NPS) as biomarkers for the prognosis of incisional wound healing in patients who underwent thoracolumbar tuberculosis surgery through the posterior approach. Methods From January 2019 to October 2021, a total of 124 patients with thoracolumbar tuberculosis who underwent posterior approach debridement and internal fixation were included in this study. We retrospectively analyzed the clinical data, including PNI and NPS. They were divided into poor wound healing (PWH) and non-PWH groups according to whether PWH developed after the operation. And according to the receiver operating characteristic curve, patients were divided into two groups through the threshold value. Risk factors were found using logistic regression analysis. Results The unfavorable outcome group had lower hemoglobin, serum albumin, Pre-albumin, PNI, and higher estimated blood loss, instrumented segments, neutrophil count, and NPS (P < 0.05). Both PNI and NPS were strongly correlated with PWH (r = 0.373, P < 0.05; r = −0.306, P < 0.05, respectively). The area under the curve (AUC) of PNI for predicting unfavorable outcomes was 0.764 (95% CI 0.662–0.865, P < 0.001), which was similar to NPS (0.808, 95% CI: 0.719–0.897, P < 0.001). Multivariate stepwise logistic regression analysis showed that PNI, NPS, the neutrophil count, the level of serum albumin, and the number of instrumented segments were independent risk factors for PWH. Conclusion Both PNI and NPS might be novel independent biomarkers and predictors of poor outcomes in incisional wound healing after STB surgery.

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Atypical spinal tuberculosis mimicking malignancy: the utility of multimodality imaging evaluation

Cited by 2 publications

References 4 publications

Surgical treatment of spinal tuberculosis: an updated review

Surgical treatment of spinal tuberculosis: an updated review

Prognostic nutritional index and naples prognostic score as biomarkers for the prognosis of incisional wound healing after thoracolumbar tuberculosis surgery

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