Atypical Squamous Cells, Cannot Exclude High-Grade Squamous Intraepithelial Lesion

Mokhtar, Ghadeer; Delatour, Nicolas L D Roustan; Assiri, Ali; Gilliatt, M Angela; Senterman, Mary K.; Islam, Shahidul

doi:10.1159/000325475

Cited by 24 publications

(23 citation statements)

References 19 publications

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“…18 This is consistent with the results obtained from the majority of the studies observed, which demonstrated CIN II+ prevalences of more than 40%, according to the biopsy results. 3,5,6,[17][18][19][20][21][22][23][24]29 Our results confirmed that at the time of the first ASC-H report, immediate intervention with colposcopy was necessary, followed by a biopsy. This validates the medical management of ASC-H that is required by the "management algorithm from the time of the first atypical Pap, " which is included in the Chilean Ministry of Health's Clinical Guidelines for Cervical Cancer.…”

Section: Asc-h Issupporting

confidence: 74%

Follow-up of women with atypical squamous cells cannot exclude high-grade squamous intraepithelial lesions (ASC-H)

2014

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Section: Asc-h Issupporting

confidence: 74%

Follow-up of women with atypical squamous cells cannot exclude high-grade squamous intraepithelial lesions (ASC-H)

2014

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“…In a study by Atjimakul et al [8], multivariate analysis showed that a high nuclear/cytoplasmic ratio and greater nuclear hyperchromasia were independent predictors for cervical intraepithelial neoplasia (CIN) ≥II. Mokhtar et al [9] found that the cytopathological feature most associated with H-SIL was the presence of coarse nuclear chromatin. However, other authors have found no significant differences in cytomorphological features between the SIL and benign follow-up groups in ASC-H patients [5].…”

Section: Discussionmentioning

confidence: 99%

Clinical Relevance of ASC-H Cytologies: Experience in a Single Tertiary Hospital

Arco

Montoro²,

D³

et al. 2016

Acta Cytologica

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Objectives: To review the cases of atypical squamous cells (ASC), cannot exclude squamous intraepithelial lesion (ASC-H) diagnosed at a single institution and to discuss the interpretation challenges and clinical management of these cases. Study Design: The ASC-H cases diagnosed at our institution from 2006 to 2015 were studied retrospectively; of 159,000 Pap smears, there were 959 cases of ASC of undetermined significance (ASC-US) and 148 cases of ASC-H. We have reviewed the clinical records of the ASC-H cases, and data have been analyzed using SPSS 20.0. Results: Median age was 43.1 years; 49.6% of the patients had previous cervical cytologies, and 55.9% of them were negative. Following ASC-H diagnosis, another smear was obtained in 97.1% of the cases and in 67.6% a biopsy was performed. Biopsy revealed low-grade dysplasia in 18.8% of the cases, high-grade dysplasia in 27.8%, and infiltrating carcinoma in 2.3%. Patients with significant lesions in histology were younger than patients with negative results (p = 0.08). A diagnosis of ASC-H/squamous intraepithelial lesion in the repeated cytology had a sensitivity of 74.2%, specificity of 39.6%, positive predictive value of 44.8%, and negative predictive value of 70% for the diagnosis of dysplasia. Conclusions: ASC-H diagnosis is associated with a high incidence of histological high-grade lesions. A repeat cytology can aid in the selection of high-risk patients, but there may be false-negative results.

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“…3, even though VersaMedium and PreservCyt medium fixed cervical swab samples were classified as HSIL and ASC-H, respectively ( Figure 1C,D), the different diagnoses do not necessarily mean different disease status as various previous studies had reported that most ASC-H cases were classified as HSIL or cervical intraepithelial neoplasia (CIN) or higher in histological follow-up. 15,16 Consistently, both diagnoses suggested that the patient receive colposcopy and HR-HPV test as stipulated in various professional guidelines. 3,4 Cellular DNA preserved with VersaMedium was stable at both 48C and room temperature for up to 4 weeks (Figure 2A,B).…”

Section: Discussionmentioning

confidence: 93%

Stability, integrity, and recovery rate of cellular nucleic acids preserved in a new liquid‐based cytology medium

Zhao

Liu

Tian

et al. 2018

Diagnostic Cytopathology

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In addition to maintaining cellular morphology, when stored at 4°C, VersaMedium preserves cellular nucleic acids and PreservCyt medium without noticeable adverse effects on the recovery rate during purification. Therefore, VersaMedium is an appropriate LBC medium for the collection and preservation of cervical swab specimens. And VersaMedium preserved cellular nucleic acids are of such high quality that they are suitable for HR-HPV qPCR test and RT-qPCR analyses.

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Atypical Squamous Cells, Cannot Exclude High-Grade Squamous Intraepithelial Lesion

Cited by 24 publications

References 19 publications

Follow-up of women with atypical squamous cells cannot exclude high-grade squamous intraepithelial lesions (ASC-H)

Follow-up of women with atypical squamous cells cannot exclude high-grade squamous intraepithelial lesions (ASC-H)

Clinical Relevance of ASC-H Cytologies: Experience in a Single Tertiary Hospital

Stability, integrity, and recovery rate of cellular nucleic acids preserved in a new liquid‐based cytology medium

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