Atypical Stromal Hyperplasia of the Prostate Gland

Abstract

Hyperplastic lesions of the prostatic stroma with atypical changes are presented and discussed. One lesion was a leiomyoma with atypical organization and a limited area of nuclear pleomorphism without mitotic figures. One was a lesion which in many portions was histologically indistinguishable from leiomyosarcoma. It, however, had certain features probably connoting less sinister behavior, and at autopsy 16 months after resection there was no evidence of recurrence or metastasis. One lesion histologically resembled fibroadenoma of the female breast. These three lesions occurred in patients more than 50 years who had symptoms and signs of prostatism. Reference is made to two previously reported lesions reminiscent of cystosarcoma phyllodes of the female breast. All the lesions were located in the craniad prostate, which is estrogen-influenced. A parallel is drawn between these atypical changes in prostatic fibromuscular stroma and atypical changes in the connective tissue stroma of the female breast.

Prostatic Stromal Sarcoma in a Young Adult: A Case Report

“…Several terms have been used to describe this disease, including cystosarcoma phyllodes [3], phyllodes tumor [4], and atypical stromal hyperplasia [5]. Gaudin et al proposed to divide prostatic sarcoma into two subtypes, PSPUMP and PSS, based on the extent of cellularity, mitotic figure, necrosis, and stromal overgrowth [1].…”

Nonepithelial tumor-like lesions of the prostate: a never-ending diagnostic problem

“…Their cells stain for vimentin, but are negative for S100 protein, desmin and myoglobin. Some of these nodules include foci of myxoid degeneration displaying increased alcian blue positivity and resembling those seen in fibromyxoid tumors of the prostate [1] (Fig. 4a).…”

Phyllodes Tumor of the Prostate

“…Prostatic cystic epithelial–stromal tumor is an extremely uncommon lesion for which there are only occasional reports in the literature [1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17]. Known by numerous terms, including cystadeno–leiomyofibroma [2], cystosarcoma phyllodes of the prostate [3], phyllodes type of atypical hyperplasia [4]and prostatic phyllodes tumor [5], this tumor bears striking histological and clinical similarities to the better–known phyllodes tumors of the female breast [18, 19].…”

“…Known by numerous terms, including cystadeno–leiomyofibroma [2], cystosarcoma phyllodes of the prostate [3], phyllodes type of atypical hyperplasia [4]and prostatic phyllodes tumor [5], this tumor bears striking histological and clinical similarities to the better–known phyllodes tumors of the female breast [18, 19]. We report on a case of phyllodes–type of atypical prostatic hyperplasia.…”