‘Atypical Ugi’ tetrazoles

Abstract

We surprisingly found that combining the substrates of Ugi tetrazole reaction gives two different constitutional isomeric Ugi products A and B. A is the expected classical Ugi products whereas B is an isomeric product (‘atypical Ugi’).

Main Chain 1,5-Disubstituted-1H-Tetrazole-Based Polymers via Ugi-Azide-Four-Multicomponent Polymerization (UA-4MCP)

“…Thus, it is noteworthy to mention that the development of feasible synthesis pathways for 1,5-DS-Ts under mild conditions with enhanced efficiency appears to be a promising avenue for a more comprehensive understanding cis -amide bond as well. In this regard, the Ugi-azide-four-multicomponent reaction (UA-4MCR) has emerged as a notably promising technique for the synthesis of varied polymer structures with diverse properties. , Remarkably, UA-4MCR not only provides a straightforward pathway toward the creation of structurally diverse polymeric architectures, under mild conditions, but it also facilitates post-polymerization modifications. , In fact, numerous UA-4MCR synthesis strategies have been developed for synthesizing in drug discovery, particularly for the synthesis of a broad array of 1,5-DS-Ts derivatives . However, there have been no reported instances of utilizing UA-4MCR for the production of main chain 1,5-DS-T-based polymers.…”

“…31,32 Remarkably, UA-4MCR not only provides a straightforward pathway toward the creation of structurally diverse polymeric architectures, under mild conditions, but it also facilitates post-polymerization modifications. 33,34 In fact, numerous UA-4MCR synthesis strategies have been developed for synthesizing in drug discovery, particularly for the synthesis of a broad array of 1,5-DS-Ts derivatives. 35 However, there have been no reported instances of utilizing UA-4MCR for the production of main chain 1,5-DS-T-based polymers.…”