Au–Ag bimetallic nanoparticles decorated silicon nanowires with fixed and dynamic hot spots for ultrasensitive 3D SERS sensing

Liao, Wenlong; Liu, Kunpng; Chen, Yangjie; Hu, Jianping; Gan, Ya

doi:10.1016/j.jallcom.2021.159136

Cited by 34 publications

(17 citation statements)

References 37 publications

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“…Recently, SERS has attracted extensive research interest due to its lower limit of detection (LOD), which can provide SERS intensity of target molecules at a concentration of 10 –12 m . [ 20,21 ] Several studies have shown that SERS can be used for biomolecular detection with the labeling and bridging of Raman reporter molecules. Wu et al.…”

Section: Introductionmentioning

confidence: 99%

“…Surface-enhanced Raman scattering (SERS) can provide specific fingerprint spectra of trace targets, with high sensitivity and nondestructivity. Recently, SERS has attracted extensive research interest due to its lower limit of detection (LOD), which can provide SERS intensity of target molecules at a concentration of 10 -12 m. [20,21] Several studies have shown that SERS can be used for biomolecular detection with the labeling and bridging of Raman reporter molecules. Wu et al have displayed the ultrasensitive and simultaneous SERS detection of multiple miRNAs using fractal gold-nanotags labeled by reporters.…”

Section: Introductionmentioning

confidence: 99%

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Highly Sensitive Exosome Detection for Early Diagnosis of Pancreatic Cancer Using Immunoassay Based on Hierarchical Surface‐Enhanced Raman Scattering Substrate

Chen

et al. 2022

Small Methods

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5 year survival rate of just 6% and a median survival of fewer than 6 months due to difficulties in the early diagnosis, PaC will be the second leading cause of cancer death by 2030. [3][4][5] Clinical diagnostic methods for PaC mainly include imaging and pathological biopsy. However, the available imaging diagnostic techniques, such as ultrasound (US), computed tomography (CT) scanning, and magnetic resonance imaging (MRI), have low diagnostic sensitivity and high requirements on operating skills. [2,[6][7][8] Normally, histopathological biopsy is a gold standard for disease diagnosis. [9] However, due to the deep position of the pancreas, biopsy will bring great harm to patients, and it needs to be punctured under the guidance of imaging and is not suitable for screening of the general population. [10,11] Moreover, the sensitivity and specificity of the widely used clinical screening biomarker carbohydrate antigen19-9 (CA19-9) are not high, and its serum level is significantly increased in inflammatory diseases of the pancreas and biliary tract, which leads its capacity for early diagnosis is not be evaluated. [12,13] Therefore, it is urgent and necessary to identify new and better biomarkers for the early diagnosis of PaC.Exosomes have emerged as potential biomarkers for pancreatic cancer (PaC). However, it is still challenging to get quantitative detection of exosomes with the specific surface receptors. In this study, a highly sensitive detection system is first constructed for the direct quantitation of specific exosomes in real samples using hierarchical surface-enhanced Raman scattering substrate (H-SERS substrate) and rapid enrichment strategy magnetic beads @ exosomes @ SERS detection probes (MEDP). It is found that the detection system (MEDP @ H-SERS substrate) could provide a 3.5 times higher SERS intensity compared with MEDP sandwich immunocomplex only. Moreover, LRG1-positive exosomes (LRG1-Exos) and GPC1-positive exosomes (GPC1-Exos) are chosen to distinguish PaC through exosome proteomics and database screening. The lower limit of detection (LOD) is 15 particles µL -1 using the MEDP @ H-SERS substrate. Significantly, the detection in clinical samples shows that the innovative combination of LRG1-Exos and GPC1-Exos could improve the diagnostic efficiency of PaC, with an area under the operating characteristic curve (AUC) of 0.95. Even for the early-stage PaC, the diagnostic accuracy is still high (AUC = 0.95). Collectively, the findings indicate that the MEDP @ H-SERS substrate has great potential for the early diagnosis of PaC.The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/smtd.202200154.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Highly Sensitive Exosome Detection for Early Diagnosis of Pancreatic Cancer Using Immunoassay Based on Hierarchical Surface‐Enhanced Raman Scattering Substrate

Chen

et al. 2022

Small Methods

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“…Similar to the case of MB, the SERS signal of RB was weakly dependent on the molecule concentrations varying from 10 −6 to 10 −9 M. This fact can indicate both high sorption efficiency and tight binding of RB molecules at the hot spots between Au-NPs on the SiNW’s surfaces. Such hot spots should be characterized by enhanced strength of the electric field, which will additionally bind and polarize the dye molecule [ 3 , 47 , 51 ]. The same effect is probably responsible for the EF spreading, which is observed for MB molecules, as shown in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

Surface-Enhanced Raman Scattering from Dye Molecules in Silicon Nanowire Structures Decorated by Gold Nanoparticles

Ikramova

Utegulov

Dikhanbayev

et al. 2022

IJMS

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Silicon nanowires (SiNWs) prepared by metal-assisted chemical etching of crystalline silicon wafers followed by deposition of plasmonic gold (Au) nanoparticles (NPs) were explored as templates for surface-enhanced Raman scattering (SERS) from probe molecules of Methylene blue and Rhodamine B. The filling factor by pores (porosity) of SiNW arrays was found to control the SERS efficiency, and the maximal enhancement was observed for the samples with porosity of 55%, which corresponded to dense arrays of SiNWs. The obtained results are discussed in terms of the electromagnetic enhancement of SERS related to the localized surface plasmon resonances in Au-NPs on SiNW’s surfaces accompanied with light scattering in the SiNW arrays. The observed SERS effect combined with the high stability of Au-NPs, scalability, and relatively simple preparation method are promising for the application of SiNW:Au-NP hybrid nanostructures as templates in molecular sensorics.

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“…16 Currently, the fabrication of SERS substrates using a combination of different metals and semiconductor-metal nanostructures are receiving considerable attention due to the synergistic effect of SERS and photocatalytic applications. 17,18 Several sources in literature report the superior SERS activity of Ag-Au bimetallic nanoparticles, Ag-Cu nanostructures, and Ag-Au-Pt trimetallic nanostructures compared to the SERS activity of a single metal. [19][20][21] The substrates exhibit tunable plasmonic wavelengths by varying their composition, length and morphology.…”

Section: Introductionmentioning

confidence: 99%

A highly sensitive SERS substrate based on a mesoporous Ag–TiO₂ thin film for the detection of dye molecules

2022

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Au–Ag bimetallic nanoparticles decorated silicon nanowires with fixed and dynamic hot spots for ultrasensitive 3D SERS sensing

Cited by 34 publications

References 37 publications

Highly Sensitive Exosome Detection for Early Diagnosis of Pancreatic Cancer Using Immunoassay Based on Hierarchical Surface‐Enhanced Raman Scattering Substrate

Highly Sensitive Exosome Detection for Early Diagnosis of Pancreatic Cancer Using Immunoassay Based on Hierarchical Surface‐Enhanced Raman Scattering Substrate

Surface-Enhanced Raman Scattering from Dye Molecules in Silicon Nanowire Structures Decorated by Gold Nanoparticles

A highly sensitive SERS substrate based on a mesoporous Ag–TiO₂ thin film for the detection of dye molecules

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Au–Ag bimetallic nanoparticles decorated silicon nanowires with fixed and dynamic hot spots for ultrasensitive 3D SERS sensing

Cited by 34 publications

References 37 publications

Highly Sensitive Exosome Detection for Early Diagnosis of Pancreatic Cancer Using Immunoassay Based on Hierarchical Surface‐Enhanced Raman Scattering Substrate

Highly Sensitive Exosome Detection for Early Diagnosis of Pancreatic Cancer Using Immunoassay Based on Hierarchical Surface‐Enhanced Raman Scattering Substrate

Surface-Enhanced Raman Scattering from Dye Molecules in Silicon Nanowire Structures Decorated by Gold Nanoparticles

A highly sensitive SERS substrate based on a mesoporous Ag–TiO2 thin film for the detection of dye molecules

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A highly sensitive SERS substrate based on a mesoporous Ag–TiO₂ thin film for the detection of dye molecules