Au–Cu<sub>2−x</sub>Se heterogeneous nanocrystals for efficient photothermal heating for cancer therapy

Zhu, Dewei; Liu, Maixian; Liu, Xin; Liu, Yang; Prasad, Paras N.; Swihart, Mark T.

doi:10.1039/c7tb01004d

Cited by 36 publications

(22 citation statements)

References 54 publications

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“…It causes negligible damage to normal tissues, and is convenient, non-invasive, remote-controllable and safe 6-8. Various photothermal agents such as Au nanoparticles (AuNPs) 9, copper NPs 10, carbon derivatives 11, transition metal sulfides 12, black titania 13, and black phosphorus (BPs) 14 have been intensively explored. Among them, AuNPs are preferred due to their high absorption ability in the near-infrared (NIR) region and excellent biocompatibility 9.…”

Section: Introductionmentioning

confidence: 99%

Zwitterionic Polymer-Gated Au@TiO₂ Core-Shell Nanoparticles for Imaging-Guided Combined Cancer Therapy

Zheng

Wang

et al. 2019

Theranostics

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With advances in nanoparticle (NP) synthesis and engineering, nanoscale agents with both therapeutic and diagnostic functions have been increasingly exploited for cancer management. Herein, we synthesized a new type of zwitterionic polymer-gated Au@TiO 2 core-shell nanoparticles, which showed that they could selectively target and efficiently eliminate cancer cells via photothermal therapy (PTT), photodynamic therapy (PDT), pH/NIR-induced drug release, and cationic therapy. Methods : In the present study, the multifunctional therapeutic agent [Mn@P(CitAPDMAEMA)@Au@TiO 2 @DOX] was prepared to treat cancer with imaging-guided combination method. Firstly, Au@TiO 2 core-shell nanoparticles (NPs) were synthesized. Taking advantage of broad and strong photoabsorption and reactive oxygen species (ROS) generation, Au@TiO 2 core-shell NPs facilitated the single light-induced PTT and PDT. Next, a chemotherapy drug doxorubicin (DOX) was loaded into Au@TiO 2 core-shell NPs. Then, a biocompatible zwitterionic polymer P(CitAPDMAEMA) was grafted to improve the hemocompatibility of NPs and prolong the circulation time. The polymer also served as a capping or switching material for pH-triggered drug release. In addition, the cationic nature of P(CitAPDMAEMA) eased the binding to human cervical cancer (HeLa) cells and effectively inhibited their growth in acidic environments (termed cationic therapy). Moreover, with Mn 2+ ions immanently chelated, Mn@P(CitAPDMAEMA)@Au@TiO 2 @DOX NPs were able to provide enhanced contrast under T 1 - or T 2 -weighted magnetic resonance imaging (MRI). Results : The in vitro and in vivo anticancer experiments demonstrated the tumor was effectively inhibited with minimal side effects by the multifunctional NPs. Conclusions : As far as we know, this is the first presentation of four therapeutic methods into one nanomaterial, which will open up a new dimension for the design of combined treatment.

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Section: Introductionmentioning

confidence: 99%

Zwitterionic Polymer-Gated Au@TiO₂ Core-Shell Nanoparticles for Imaging-Guided Combined Cancer Therapy

Zheng

Wang

et al. 2019

Theranostics

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“…They have found applications in the areas such as PT therapy, bioimaging and optical NIR energy controlling and utility . Combination of metal NPs with vacancy‐doped plasmonic semiconductor nanocrystals together will open the access to unexplored phenomena resulting from the coupling between the collective electronic oscillation at surface of metal NPs and the hole oscillation in the neighboring semiconductors . Many metal‐semiconductor hetero‐nanostructures have been synthesized and the plasmonic properties have been investigated .…”

Section: Introductionmentioning

confidence: 99%

Coupling Resonances of Surface Plasmon in Gold Nanorod/Copper Chalcogenide Core−Shell Nanostructures and Their Enhanced Photothermal Effect

Pan

Liu

et al. 2018

ChemPhysChem

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Dual plasmonic Au@Cu S core-shell nanorods (NRs) have been fabricated by using a hydrothermal method and plasmon-coupled effect between the Au core and Cu S shell in the near-infrared (NIR) region. The extinction spectrum of Au@Cu S NRs is dominated by the surface plasmon resonance (SPR) of the Cu S shell, the transverse surface plasmon resonance (TSPR), and the longitudinal surface plasmon resonance (LSPR) of the Au NRs. With the Cu S shell increasing (fixed Au NRs), the TSPR peak slightly redshifts and the LSPR and SPR peaks blueshift, owing to competition between the redshift of the refractive index effect and blueshift from the plasmon coupled effect. Although, for Au@Cu S NRs, only TSPR and LSPR peaks can be seen and a redshift arises with the increasing Cu S shell thickness, implying that no plasmonic coupling between Au NRs and Cu S shell occurred. The extinction spectrum of the Au@Cu S NRs with three coupled resonance peaks is simulated by using the FDTD method, taking into account the electron-transfer effect. The dispersion properties of the coupling of Au@Cu S NRs with the LSPR of the initial Au core are studied experimentally by changing the length of the Au NRs, which are explained theoretically by the coupled harmonic oscillator model. The calculated coupled coefficients between SPR of the Cu S shell and LSPR of the Au NRs is 180 meV, which is much stronger than that of TSPR of Au NRs of 55 meV. Finally, the enhanced photothermal effect of Au@Cu S NRs has been demonstrated.

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“…As for carbon materials such as carbon nanotubes and graphene, despite the stable property they present, the relatively low optical absorption coefficient and complicated conditions for preparation and functionalization restricted their further development 24 . While hybrid nanoparticles such as Cu and Au hybrid nanoparticles lack reliable and reproducible synthetic procedures 25,26 . Meanwhile, semiconductor photothermal conversion materials, such as CuCo2S4 NCs, are receiving much attention due to their simple preparation, low price, stable performance and easy functionalization [27][28][29][30][31][32] .…”

Section: Introductionmentioning

confidence: 99%

CuCo₂S₄ nanocrystals as a nanoplatform for photothermal therapy of arterial inflammation

Zhang

Liu

et al. 2019

Nanoscale

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Au–Cu_2−xSe heterogeneous nanocrystals for efficient photothermal heating for cancer therapy

Abstract: In this study, we show that Au–Cu2−xSe heterogeneous nanocrystals have great promise for use in photothermal therapy (PTT).

Cited by 36 publications

References 54 publications

Zwitterionic Polymer-Gated Au@TiO₂ Core-Shell Nanoparticles for Imaging-Guided Combined Cancer Therapy

Zwitterionic Polymer-Gated Au@TiO₂ Core-Shell Nanoparticles for Imaging-Guided Combined Cancer Therapy

Coupling Resonances of Surface Plasmon in Gold Nanorod/Copper Chalcogenide Core−Shell Nanostructures and Their Enhanced Photothermal Effect

CuCo₂S₄ nanocrystals as a nanoplatform for photothermal therapy of arterial inflammation

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Au–Cu2−xSe heterogeneous nanocrystals for efficient photothermal heating for cancer therapy

Abstract: In this study, we show that Au–Cu2−xSe heterogeneous nanocrystals have great promise for use in photothermal therapy (PTT).

Cited by 36 publications

References 54 publications

Zwitterionic Polymer-Gated Au@TiO2 Core-Shell Nanoparticles for Imaging-Guided Combined Cancer Therapy

Zwitterionic Polymer-Gated Au@TiO2 Core-Shell Nanoparticles for Imaging-Guided Combined Cancer Therapy

Coupling Resonances of Surface Plasmon in Gold Nanorod/Copper Chalcogenide Core−Shell Nanostructures and Their Enhanced Photothermal Effect

CuCo2S4 nanocrystals as a nanoplatform for photothermal therapy of arterial inflammation

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Au–Cu_2−xSe heterogeneous nanocrystals for efficient photothermal heating for cancer therapy

Zwitterionic Polymer-Gated Au@TiO₂ Core-Shell Nanoparticles for Imaging-Guided Combined Cancer Therapy

Zwitterionic Polymer-Gated Au@TiO₂ Core-Shell Nanoparticles for Imaging-Guided Combined Cancer Therapy

CuCo₂S₄ nanocrystals as a nanoplatform for photothermal therapy of arterial inflammation