Au(I)-Catalyzed Regioselective Hydrofluorination of Propargylamines Using Aqueous HF

Abstract

Gold-catalyzed regioselective hydrofluorination of alkynes using aqueous HF has been achieved by employing an amide directing group. For both aryl- and alkyl-substituted propargylamines, the fluorination occurred at the site distal to the amino group.