Au@MnO Nanoflowers: Hybrid Nanocomposites for Selective Dual Functionalization and Imaging

Schladt, Thomas D.; Shukoor, Mohammed Ibrahim; Schneider, K.; Tahir, Muhammad Nawaz; Natálio, Filipe; Ament, Irene; Becker, Jan; Jochum, Florian D.; Weber, Stefan A. L.; Köhler, Oskar; Théato, Patrick; Schreiber, Laura M.; Sönnichsen, Carsten; Schröder, Heinz C.; Müller, Wernér E.G.; Tremel, Wolfgang

doi:10.1002/anie.200906689

Cited by 139 publications

(82 citation statements)

References 76 publications

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“…For example, it has been proposed that distinct material modules of a HNC can be used as anchoring platforms for the site-specific attachment of selected biomolecules or ligands (Jun et al, 2007;Gao et al, 2009;Bigall et al, 2012;Lim and Majetich, 2013). In addition, while a metal or semiconductor domain can enable optical detection (e.g., via excitonic or LSPR absorption, or photoluminescence), a magnetic module can be utilized for complementary purposes, such as for magnetic resonance imaging (MRI), optical imaging, and magnetic separation (Choi et al, , 2008Jun et al, 2007;Jiang et al, 2008;Xu et al, 2008;Gao et al, 2009;Schladt et al, 2010;Bigall et al, 2012;Lim and Majetich, 2013). The existence of bonding heterointerfaces through which dissimilar materials can electronically communicate has clearly been recognized to impact on the magnetic (Xu et al, 2008;Lee et al, 2010a;Umut et al, 2012;Pineider et al, 2013;Kim and Song, 2014;Schick et al, 2014;López-Ortega et al, 2015;Velasco et al, 2015), optical (Levin et al, 2009;Korobchevskaya et al, 2011;Comin et al, 2012), transport (Lee et al, 2010a), magneto-optical Armelles et al, 2013), (electro)catalytic (Yin et al, 2008;Wang et al, 2009aWu et al, 2009;Lee et al, 2010b;George et al, 2011aGeorge et al, , 2013Jang et al, 2011b;Lin and Doong, 2011;Chen et al, 2012;Sun et al, 2012), and energy-storing propertie...…”

Section: Heterogeneous Nucleation Direct Heterogeneous Nucleationmentioning

confidence: 99%

“…Examples of MHNCs derived from heterogeneous deposition pathways are collected in Figures 2B-Q. Thermal decomposition of metallorganic precursors in the presence of preformed noble metal, Fe 3 O 4 , FePt, or UO 2 seeds in non-coordinating solvents, such as octadecene (ODE) or phenyl ether containing oleic acid (OLAC), oleyl amine (OLAM), and/or tri-n-octyl phosphine (TOP) surfactants at 200-300°C has enabled access to hetero-dimer HNCs made of two nearly spherical and/or cubic-shaped domains epitaxially interconnected, such as of Me-Fe 3 O 4 (Me = Au, AuAg, PtPd, AuPd, AuPt, Pt, Pd, Ni, Cu) (Yu et al, 2005;Shi et al, 2006b;Choi et al, 2008;Wei et al, 2008;Wang et al, 2009aGeorge et al, 2011aGeorge et al, , 2013Jang et al, 2011a;Lin and Doong, 2011;Nakhjavan et al, 2011;Zhai et al, 2011;Leung et al, 2012;Sun et al, 2012;Kim and Song, 2014;Victor et al, 2015), Fe 3 O 4 -MnO , Au-MnO (Choi et al, 2008;Schladt et al, 2010) (He et al, 2009;Lee et al, 2010a;Wu et al, 2011a;Schladt et al, 2012;Liu et al, 2014;Yang et al, 2015), respectively. Depending on the geometric features of the two-component domains, these heterostructures exhibit various morphological profiles, spanning from peanut-, dumbbell-, brick-to flower-like (Figures 2B-D).…”

Section: Heterogeneous Nucleation Direct Heterogeneous Nucleationmentioning

confidence: 99%

“…In some cases, the nature of ligands that were originally bound to the surface of the starting seeds or were added during the seeding stage was found to be critical to driving the preference for a hetero-dimer topology over a core@shell one, which pointed to the influence of kinetic processes on topology selection (Yu et al, 2005;Choi et al, 2008;Jiang et al, 2008;Wei et al, 2008;He et al, 2009;Lee et al, 2010a;Schladt et al, 2010;Nakhjavan et al, 2011;Zhai et al, 2011).…”

Section: Heterogeneous Nucleation Direct Heterogeneous Nucleationmentioning

confidence: 99%

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Colloidal Magnetic Heterostructured Nanocrystals with Asymmetric Topologies: Seeded-Growth Synthetic Routes and Formation Mechanisms

2016

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Colloidal inorganic nanocrystals (NCs), free-standing crystalline nanostructures generated and processed in solution phase, represent an important class of advanced nanoscale materials owing to the flexibility with which their physical-chemical properties can be controlled through synthetic tailoring of their compositional, structural, and geometric features and the versatility with which they can be integrated in technological fields as diverse as optoelectronics, energy storage/conversion/production, catalysis, and biomedicine. In recent years, building upon mechanistic knowledge acquired on the thermodynamic and kinetic processes that underlie NC evolution in liquid media, synthetic nanochemistry research has made impressive advances, opening new possibilities for the design, creation, and mastering of increasingly complex "colloidal molecules," in which NC modules of different materials are clustered together via solid-state bonding interfaces into free-standing, easily processable multifunctional nanocomposite systems. This review will provide a glimpse into this fast-growing research field by illustrating progress achieved in the wet-chemical development of last-generation breeds of allinorganic heterostructured nanocrystals (HNCs) in asymmetric non-onionlike geometries, inorganic analogues of polyfunctional organic molecules, in which distinct nanoscale crystalline modules are interconnected in heterodimer, hetero-oligomer, and anisotropic multidomain architectures via epitaxial heterointerfaces of limited extension. The focus will be on modular HNCs entailing at least one magnetic material component combined with semiconductors and/or metals, which hold potential for generating enhanced or unconventional magnetic behavior, while offering diversified or even new chemical-physical properties and functional capabilities. The available toolkit of synthetic strategies, all based on the manipulation of seeded-growth techniques, will be described, revisited, and critically interpreted within the framework of the currently understood mechanisms of colloidal heteroepitaxy.

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Section: Heterogeneous Nucleation Direct Heterogeneous Nucleationmentioning

confidence: 99%

Section: Heterogeneous Nucleation Direct Heterogeneous Nucleationmentioning

confidence: 99%

Section: Heterogeneous Nucleation Direct Heterogeneous Nucleationmentioning

confidence: 99%

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Colloidal Magnetic Heterostructured Nanocrystals with Asymmetric Topologies: Seeded-Growth Synthetic Routes and Formation Mechanisms

2016

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“…Surface modified magnetic nanoparticles with certain biocompatible polymers have been extensively studied in magnetic-field-directed drug delivery and diagnostic imaging. [32][33][34] In this work, the uniformly sized oleic-capped MnO NPs dispersed in nonpolar organic solvent were synthesized by the thermal decomposition of Mn-oleate complex following a procedure previously reported by Hyeon and co-workers. 26 The hydrocarbon coated on the surface of the oleic-capped MnO NPs makes them hydrophobic and only soluble in non-polar or weakly polar organic solvents.…”

Section: Introductionmentioning

confidence: 99%

Water-Soluble and Biocompatible MnO@PVP Nanoparticles for MR Imaging <I>In Vitro</I> and <I>In Vivo</I>

Hu¹,

Ji²,

Wang³

et al. 2013

Journal of Biomedical Nanotechnology

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The uniform-sized manganese oxide nanoparticles (the oleic-capped MnO NPs) were synthesized by the thermal decomposition of Mn-oleate complex and were transferred into water with the help of cationic surfactant of cetyltrimethyl ammonium bromide (CTAB), then the poly(vinylpyrrolidone) (PVP) membrane was further coated on to them with the aid of anionic dispersant of poly(styrenesulfonate) (PSS) by layer-by-layer electrostatic assembly to render them water soluble and biocompatible. They were characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS), X-ray diffraction (XRD), Fourier-transform infrared (FTIR) and MTT assay. In vitro cellular uptake test revealed the MnO@PVP NPs were low cytotoxic, biocompatible and could be used as a T,-positive contrast agent for passive targeting magnetic resonance imaging (MRI). Interestingly, signal enhancement in cerebral spinal fluid (CSF) spaces in vivo experiment suggested that the MnO@PVP NPs can pass through the blood brain barrier (BBB). These results show that MnO@PVP NPs are good candidates as MRI contrast agents with the lack of cytotoxicity and have great potential applications in magnetic nano-device and biomagnetic field.

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“…Although the effect of shape of MNP on their magnetic properties is not extensively studied, a few investigations have been reported in the literature on ferrite nanocubes, maghemite nanorods, NiFe wires, cobalt nanodiscs, tetrapods, and Au-MnO nanoflowers showing a strong dependence of M s on the shapes of the nanoparticles [27][28][29][30][31][32][33][34][35][36]. Higher M s values have been observed for the cubic MNP compared to the spherical MNP of the same size [37].…”

Section: Effect Of Size Shape and Compositionmentioning

confidence: 99%

Gd-Doped Superparamagnetic Magnetite Nanoparticles for Potential Cancer Theranostics

Palihawadana-Arachchige¹,

Naik²,

Vaishnava³

et al. 2017

Nanostructured Materials - Fabrication to Applications

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Nanotechnology has facilitated the applications of a class of nanomaterials called superparamagnetic iron oxide nanoparticles (SPIONs) in cancer theranostics. This is a new discipline in biomedicine that combines therapy and diagnosis in one platform. The multifunctional SPIONs, which are capable of detecting, visualizing, and destroying the neoplastic cells with fewer side effects than the conventional therapies, are reviewed in this chapter for theranostic applications. The chapter summarizes the design parameters such as size, shape, coating, and target ligand functionalization of SPIONs, which enhance their ability to diagnose and treat cancer. The review discusses the methods of synthesizing SPIONs, their structural, morphological, and magnetic properties that are important for theranostics. The applications of SPIONs for drug delivery, magnetic resonance imaging, and magnetic hyperthermia therapy (MHT) are included. The results of our recent MHT study on Gd-doped SPION as a possible theranostic agent are highlighted. We have also discussed the challenges and outlook on the future research for theranostics in clinical settings.

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Au@MnO Nanoflowers: Hybrid Nanocomposites for Selective Dual Functionalization and Imaging

Cited by 139 publications

References 76 publications

Colloidal Magnetic Heterostructured Nanocrystals with Asymmetric Topologies: Seeded-Growth Synthetic Routes and Formation Mechanisms

Colloidal Magnetic Heterostructured Nanocrystals with Asymmetric Topologies: Seeded-Growth Synthetic Routes and Formation Mechanisms

Water-Soluble and Biocompatible MnO@PVP Nanoparticles for MR Imaging <I>In Vitro</I> and <I>In Vivo</I>

Gd-Doped Superparamagnetic Magnetite Nanoparticles for Potential Cancer Theranostics

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