Au nano-urchins enabled localized surface plasmon resonance sensing of beta amyloid fibrillation

Nair, Radhika V.; Pae, Jian Yi; Padmanabhan, Parasuraman; Gulyás, Balázs; Murukeshan, Vadakke Matham

doi:10.1039/d0na00164c

Cited by 21 publications

(8 citation statements)

References 51 publications

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“…On the other hand, the progress in the fibrillation process of Aβ 1–42 at nM concentrations was sensed according to the reduction of LSPR peak intensity of gold nano-urchins (AuNUs). With this method, the LSPR of AuNUs at 650 nm gradually decreased with time ( Figure 8 B) an effect that was also evident at various fibrillation stages of Aβ 1–42 ( Figure 8 B) [ 122 ]. In addition, Aβ fibrillation at nM concentrations using AuNSps and AuNUs revealed that AuNSps did not show significant changes in optical absorption compared to AuNUs at various fibrillation stages ( Figure 8 B), thus limiting its capacity for sensing low concentrations in the fibrillation process.…”

Section: Plasmonic Biosensors For In Vitro Optical Detection Of Admentioning

confidence: 98%

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Plasmonic Nanoparticles as Optical Sensing Probes for the Detection of Alzheimer’s Disease

Oyarzún

Tapia-Arellano

Cabrera

et al. 2021

Sensors

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Alzheimer’s disease (AD), considered a common type of dementia, is mainly characterized by a progressive loss of memory and cognitive functions. Although its cause is multifactorial, it has been associated with the accumulation of toxic aggregates of the amyloid-β peptide (Aβ) and neurofibrillary tangles (NFTs) of tau protein. At present, the development of highly sensitive, high cost-effective, and non-invasive diagnostic tools for AD remains a challenge. In the last decades, nanomaterials have emerged as an interesting and useful tool in nanomedicine for diagnostics and therapy. In particular, plasmonic nanoparticles are well-known to display unique optical properties derived from their localized surface plasmon resonance (LSPR), allowing their use as transducers in various sensing configurations and enhancing detection sensitivity. Herein, this review focuses on current advances in in vitro sensing techniques such as Surface-enhanced Raman scattering (SERS), Surface-enhanced fluorescence (SEF), colorimetric, and LSPR using plasmonic nanoparticles for improving the sensitivity in the detection of main biomarkers related to AD in body fluids. Additionally, we refer to the use of plasmonic nanoparticles for in vivo imaging studies in AD.

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Section: Plasmonic Biosensors For In Vitro Optical Detection Of Admentioning

confidence: 98%

“…LSPR sensing of various fibrillation stages of Aβ 1-42 and comparison between LSPR sensing of Aβ fibrillation at nM range, using AuNUs (blue) and AuNSps (red). The three figures were obtained from ref [122]. published by The Royal Society of Chemistry.…”

mentioning

confidence: 99%

Plasmonic Nanoparticles as Optical Sensing Probes for the Detection of Alzheimer’s Disease

Oyarzún

Tapia-Arellano

Cabrera

et al. 2021

Sensors

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“…The same authors provide also a very good review on the strain transfer theory of fiber optics [26]. In several studies, the Surface Plasmon Resonance (SPR) technique was utilized to improve the sensitivity and durability of the sensors [27][28][29][30][31][32][33]. The purpose of enhancing the sensitivity and durability of the sensor is to enhance the key parameters of the system, e.g.…”

Section: Introductionmentioning

confidence: 99%

Coating effects of a strain sensor on durability and sensitivity using the fiber loop ringdown spectroscopy technique

Kaya,

Esenturk,

Asici

et al. 2024

Phys. Scr.

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A sensor region in a single-mode optical fiber loop was created and utilized in order to study the coating effect on sensor durability and system sensitivity by the Fiber Loop Ringdown Spectroscopy (FLRDS) technique. The sensor system was simply designed without any additional optical components. The bending loss theory in the single-mode fiber (SMF) was taken into account in data calculation. After stretching was performed on 10.0 cm long coated and noncoated sensorheads from the mid-points, the strain detection limits were determined as 5.3345 με and 6.7497 με with bare and coated sensorheads, respectively. The purpose of this study is to analyze the effect of N,N-Diethyl-p-phenylenediamine (NDPD) coating of the sensorhead on the sensor durability and sensitivity. The baseline stability of the system was obtained as 1.18% by considering a hundred consecutive data. Regarding to obtained results, the difference between calculated total optical losses of FLRDS systems with noncoated and NDPD coated sensorheads shows that coating sensorhead enhanced the sensor durability and the system sensitivity. An FLRDS system with high sensitivity, simple design and easy setup offers real-time measurement with continuous monitoring and provides advantages on durability by modification the sensorhead such as NDPD coating. Due to its attractive features such as low cost, simplicity, easy setup, high sensitivity, increased durability and continuous monitoring, an FLRDS system has a wide range of application areas in structural health monitoring, transportation, early detection, biomedical, chemical trace elements, rail and asphalt applications for continuous monitoring in a real-time merit.

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“…Among all techniques and methods, optical-based techniques have advantages in fast and direct monitoring of targets, simple system design, high sensitivity, real-time measurement, a small volume of samples, and system portability [30][31][32][33][34][35]. To overcome the aforementioned limitations, optical sensor-based methods such as optical nanosensors and surface plasmon resonance (SPR) were developed in the last decade [3,17,[35][36][37][38][39][40]. Fiber optic-based measurement techniques allow high accuracy, fast response, low cost, simplicity, portability, specificity, and higher sensitivity [41,42].…”

Section: Introductionmentioning

confidence: 99%

Application of fiber loop ringdown spectroscopy technique for a new approach to beta-amyloid monitoring for Alzheimer Disease’s early detection

Kaya,

Oz,

Esenturk

2024

Biomed. Phys. Eng. Express

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A novel fiber optic biosensor was purposed for a new approach to monitor amyloid beta protein fragment 1-42 (Aβ42) for Alzheimer’s Disease (AD) early detection. The sensor was fabricated by etching a part of fiber from single mode fiber loop in pure hydrofluoric acid solution and utilized as a Local Optical Refractometer (LOR) to monitor the change Aβ42 concentration in Artificial Cerebrospinal Fluid (ACSF). The Fiber Loop Ringdown Spectroscopy (FLRDS) technique is an ultra-sensitive measurement technique with low-cost, high sensitivity, real-time measurement, continuous measurement and portability features that was utilized with a fiber optic sensor for the first time for the detection of a biological signature in an ACSF environment. Here, the measurement is based on the total optical loss detection when specially fabricated sensor heads were immersed into ACSF solutions with and without different concentrations of Aβ42 biomarkers since the bulk refractive index change was performed. Baseline stability and the reference ring down times of the sensor head were measured in the air as 0.87% and 441.6 μs  3.9 μs, respectively. Afterward, the total optical loss of the system was measured when the sensor head was immersed in deionized water, ACSF solution, and ACSF solutions with Aβ42 in different concentrations. The lowest Aβ42 concentration of 2 ppm was detected by LOR. Results showed that LOR fabricated by single-mode fibers for FLRDS system design are promising candidates to be utilized as fiber optic biosensors after sensor head modification and have a high potential for early detection applications of not only AD but possibly also several fatal diseases such as diabetes and cancer.

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Au nano-urchins enabled localized surface plasmon resonance sensing of beta amyloid fibrillation

Abstract: LSPR sensing of structural changes of beta amyloid fibrillation at the nano-molar concentration level using Au nano-urchins.

Cited by 21 publications

References 51 publications

Plasmonic Nanoparticles as Optical Sensing Probes for the Detection of Alzheimer’s Disease

Plasmonic Nanoparticles as Optical Sensing Probes for the Detection of Alzheimer’s Disease

Coating effects of a strain sensor on durability and sensitivity using the fiber loop ringdown spectroscopy technique

Application of fiber loop ringdown spectroscopy technique for a new approach to beta-amyloid monitoring for Alzheimer Disease’s early detection

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