Au12C68: a hollow noble metal carbide

Zheng, Mengmeng; Zhao, Hui-Yan; Ma, Hong-Man; Guo, Jingjing; Xu, Rui-Ping; Wang, Jing; Liu, Ying

doi:10.1007/s00214-022-02881-x

Cited by 1 publication

(1 citation statement)

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“…These applications necessitate the preservation of protein activity and stability across varied and frequently challenging conditions or within living systems. Additionally, the effective delivery of proteins into cells is paramount in maximizing their therapeutic potential and ensuring target specificity [2] . Recent advancements have seen the biomineralization of proteins into porous nanomaterials, such as metal–organic frameworks (MOFs) [3] and covalent organic frameworks (COFs) [4] to overcome challenges related to protein stability and intracellular delivery.…”

Section: Introductionmentioning

confidence: 99%

Protein‐Integrated Hydrogen‐Bonded Organic Frameworks: Chemistry and Biomedical Applications

Li,

Ma,

Wang

2024

Angewandte Chemie

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Hydrogen‐bonded organic frameworks (HOFs) are porous nanomaterials that offer exceptional biocompatibility and versatility for integrating proteins for biomedical applications. This minireview concisely discusses recent advancements in the chemistry and functionality of protein‐HOF interfaces. It particularly focuses on strategic methodologies, such as the careful selection of building blocks and the genetic engineering of proteins, to facilitate protein‐HOF interactions. We examine the role of enzyme encapsulation within HOFs, highlighting its capability to preserve enzyme function, a crucial aspect for applications in biosensing and disease diagnosis. Moreover, we discuss the emerging utility of nanoscale HOFs for intracellular protein delivery, illustrating their applicability as nanoreactors for intracellular catalysis and neuroprotective biorthogonal catalysis within cellular compartments. We highlight the significant advancement of designing biodegradable HOFs tailored for cytosolic protein delivery, underscoring their promising application in targeted cancer therapies. Finally, we provide a perspective viewpoint on the design of biocompatible protein‐HOF assemblies, underlining their promising prospects in drug delivery, disease diagnosis, and broader biomedical applications.

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Section: Introductionmentioning

confidence: 99%