Head-related transfer function (HRTF), which varies across individuals at the same direction, has grabbed widespread attention in the field of acoustics and been used in many scenarios. In order to in-depth investigate the performance of individualized HRTFs on perceiving the spatialization cues, this study presents an integrated algorithm to obtain individualized HRTFs, and explores the advancement of such individualized HRTFs in perceiving the spatialization cues through two different binaural experiments. An integrated method for HRTF individualization on the use of Principle Component Analysis (PCA), Multiple Linear Regression (MLR) and Partial Least Square Regression (PLSR) was presented first. The objective evaluation was then made to verify the algorithmic effectiveness of that method. Next, two subjective experiments were conducted to explore the advancement of individualized HRTFs in perceiving the spatialization cues. One was auditory directional discrimination degree based on semantic differential method, in which the azimuth information of sound sources was told to the listeners before listening. The other was auditory localization, in which the azimuth information was not told to the listeners before listening. The corresponding statistical analyses for the subjective experimental results were made. All the experimental results support that individualized HRTFs obtained from the presented method achieve a preferable performance in perceiving the spatialization cues.