Audiospatial evoked potentials for the assessment of spatial attention deficits in patients with severe cerebrovascular accidents

Walter, Mario de la Piedra; Notbohm, Annika; Eling, Paul; Hildebrandt, Helmut

doi:10.1080/13803395.2021.1984397

Cited by 2 publications

(1 citation statement)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous work with EEG has revealed differences in sensory processing between stroke patients and healthy controls. Most consistently, event-related potentials (ERPs) related to early perceptual (e.g., the N100) 22–26 and decisional processes (e.g., the P300 and more specifically the P3b subcomponent) 24,25,27–32 are suppressed or delayed in the lesioned hemisphere while stroke patients undertake speeded tasks, relative to ERPs in the healthy hemisphere. However, the majority of studies have selectively examined patients with right hemisphere lesions in the context of spatial neglect 23,25,26,28,31,33–39 , which does not wholly account for the broader incidence of slowed contralesional responding.…”

mentioning

confidence: 99%

Neurophysiological mechanisms underlying post-stroke deficits in contralesional perceptual processing

Pearce,

Loughnane,

Chong

et al. 2023

Preprint

View full text Add to dashboard Cite

Slowed responding to sensory inputs presented in contralesional space is pervasive following unilateral cerebral stroke, but the causal neurophysiological pathway by which this occurs remains unclear. To this end, here we leverage a perceptual decision-making framework to disambiguate information processing stages between sensation and action in 30 unilateral stroke patients (18 right hemisphere, 12 left hemisphere) and 27 neurologically healthy adults. By recording neural activity using electroencephalography (EEG) during task performance, we show that the relationship between strokes in either hemisphere and slowed contralesional response times is sequentially mediated by weaker target selection signals in the contralateral hemisphere (the N2c ERP), and subsequently delayed evidence accumulation signals (the centroparietal positivity). Notably, asymmetries in CPP and response times across hemispheres are associated with everyday functioning. Together, these data suggest a plausible neurophysiological pathway by which post-stroke contralesional slowing arises and highlight the utility of neurophysiological assessments for tracking clinically relevant behaviour.

show abstract