Audiovestibular and vaccination complications of COVID-19

Gabr, Takwa A.; Kotait, Mona; Moaty, Asmaa Salah

doi:10.1186/s43163-022-00290-2

Cited by 6 publications

(8 citation statements)

References 68 publications

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“…While other published literature were in line with our hearing loss findings [20,21,22], we are the first to confirm an increased incidence of tinnitus and vertigo post COVID-19 vaccines. [23,24] Although the pathophysiology of audiovestibular events following vaccination is unclear, proposed mechanisms include an immune mediated injury due to exaggerated cytokine responses leading to vasculitic events, antibody cross-reactivity and molecular mimicry [2]. Another suggested mechanism is that mRNA vaccines can cause reactivation of previous latent viruses resulting in sudden hearing loss [25].…”

Section: Discussionmentioning

confidence: 99%

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Audiovestibular adverse events following COVID-19 vaccinations

Shetty,

Morgan,

Phuong

et al. 2023

Preprint

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ImportanceEvidence regarding audiovestibular adverse events post COVID-19 vaccination to date has been inconclusive regarding a potential etiological association. This study used a multi-data source approach to assess incidence of these events following COVID-19 vaccination.ObjectiveTo determine if there was an increase in audiovestibular adverse events following COVID-19 vaccination in South-eastern Australia during January 2021 – March 2023.DesignRetrospective observational analysis of spontaneous reports of audiovestibular events to a statewide vaccine safety surveillance service, SAEFVIC, as well as accompanying self-controlled case series (SCCS) analysis using general practice data collected via the POpulation Level Analysis and Reporting (POLAR) tool with permission from Primary Health Networks (PHNs) as the de-identified dataset owners in Victoria and New South Wales.SettingVictoria and New South Wales (NSW), Australia.ParticipantsVictorians who spontaneously reported an audiovestibular-related symptom or diagnosis to SAEFVIC, and people in Victoria and NSW who presented to a POLAR GP registered practice with a new audiovestibular diagnosis.ExposuresCOVID-19 vaccination with adenovirus vector, mRNA or protein-subunit vaccine.Outcomes and MeasuresIn SAEFVIC, audiovestibular events of interest were ascertained through searching key words in the vaccine safety database. Reporting rates were calculated and compared per 100,000 COVID-19 vaccine doses administered and recorded in the Australian Immunisation Register (AIR). Audiovestibular presentations of interest were isolated from the general practice dataset aggregated by POLAR, by searching for relevant SNOMED CT codes. Similarly, relative incidence (RI) was calculated for all COVID-19 vaccine types.ResultsThis study demonstrates an increase in general practice presentations of vertigo following mRNA vaccines (RI= 1.40P<.001), and tinnitus following both the adenovirus vector and mRNA vaccines (RI= 2.25,P<.001 and 1.53,P<.001 respectively). There was no increase in hearing loss following any COVID-19 vaccinations.Conclusions and RelevanceThis is the first study that demonstrates an increase in audiovestibular presentations following COVID-19 vaccination, in particular, vertigo and tinnitus. Healthcare providers and vaccinees should be alert to potential audiovestibular complaints after COVID-19 vaccination. Our analysis highlights the importance of using large real-world datasets to gather reliable evidence for public health decision making.KEY POINTSQuestionIs there an increase in audiovestibular adverse events after COVID-19 vaccination (adenovirus vector [AstraZeneca’s Vaxzervria® ChadOx1-S], mRNA [Pfizer-BioNTech’s Comirnaty® BNT162b2 and Moderna’s Spikevax®] or protein-subunit [Novavax’s Nuvaxovid®])?FindingsThis Australian study using spontaneous surveillance reports and large-scale general practice data, found an increase in incidence related to vertigo following mRNA vaccines (Relative Incidence = 1.40,P<.001), and tinnitus following both adenovirus vector and mRNA vaccines (Relative Incidence = 2.25,P<.001 and 1.53,P<.001 respectively). No increase in hearing loss following vaccination was observed.MeaningHealthcare providers and vaccinees should be alert to potential audiovestibular complaints following COVID-19 vaccination.

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Section: Discussionmentioning

confidence: 99%

“…Following the implementation of COVID 19 vaccines commencing in December 2020[1], concerns have been raised globally about a possible association between COVID-19 vaccinations and audiovestibular conditions [2]. Australia's COVID-19 vaccination rollout commenced on 22 February 2021 [3].…”

Section: Introductionmentioning

confidence: 99%

Audiovestibular adverse events following COVID-19 vaccinations

Shetty,

Morgan,

Phuong

et al. 2023

Preprint

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“…SARS-CoV-2, the infectious agent for the ongoing COVID-19 pandemic, often has long-term impacts on the health of individuals who survive initial infection [1][2][3][4][5][6] and can lead to premature death [1]. Multiple organ systems may be singly or interactively impacted by the daily living (ADL), and reduced quality of life (QOL) [6,10] gustatory and gastrointestinal impacts [4] neural system invasion through the neuro/olfactory bulb linkage [5,6] and/or through the angiotensin-converting enzyme 2 mechanism found in alveoli, glial cells, and neurons [4] sensory loss (most commonly taste and smell, but also hearing; [2,4] neurological impairments and multiorgan failure [4,5] cognitive processing difficulties sometimes referred to as "brain fog" [3,6], and inner-ear-related conditions such as dizziness, vertigo, and tinnitus [2,4,16]. No universal upper length of chronicity limit has been established, though an upper limit of one year is sometimes noted [3,17].…”

Section: Introductionmentioning

confidence: 99%

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confidence: 99%

Long COVID and COVID-Induced Ménière's Disease: Overview and Recommendations

S¹,

Mahmoud²

2023

J Otolaryngol Rhinol

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SARS-CoV-2, the infectious agent causing the ongoing COVID-19 pandemic, often has long-term impacts on the health of those who survive initial infection [1][2][3][4][5][6] and can lead to premature death [1]. An understudied outcome of COVID-19 is its effect on the audiovestibular system [7,8]. Impacts of the virus on this system create a pattern of disability similar to that of Ménière's Disease (MD), a progressively degenerative condition that can cause severe falls and deafness [1]. COVID-induced MD (CMD) impacts physical, social, psychological, financial, and other dimensions of health in profound ways that must be addressed throughout public and individualized health systems as early in its course as possible in order to increase individuals' quality of life and decrease costs to individuals and society. In this paper, we define "post-COVID syndrome," describe MD in more detail, and provide additional information on how MD impacts health, quality of life, and potential social and economic costs of COVID-19-induced MD (CMD). We also discuss options for early detection and intervention. Finally, we provide suggestions for public-and communitybased health approaches to addressing MD and COVID-19-originated MD (CMD) that focus on early detection and intervention, provider education, integrated treatment options that include use of interdisciplinary teams and paraprofessionals, fall prevention, and future avenues for research. LitErAturE rEviEw Check for updatesMénière's Disease (MD) has historically been diagnosed primarily in people aged 40-60 (AHRF, 2022). Its effects on the inner ear include stiffening of the "hairs" (stereocilia) that line the cochlea, tinnitus, deafness, dizziness, vertigo and loss of balance that can lead to increased risk for falls [7,12]. Falls caused by MD typically occur without warning, loss of consciousness, or neurological symptoms and are known as drop attacks, Tumarkin drop attacks, drop vestibular attacks, or otolithic crises [12]. These can be severe, especially before MD/CMD is identified, and early in symptom

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“…8 During the pre-vaccination clinical trials, auditory complications were not reported as a side effect. 9 Shortly after vaccination, auditory side effects, including sudden sensorineural hearing loss (SSNHL), tinnitus, earache and/or exacerbation of Menière's, and autoimmune inner ear disease, were reported in the vaccine adverse events reporting system established by the Centers for Disease Control and Prevention and FDA in the United States. 7,10,11 SSNHL is a hearing loss of ⩾30 dB at three consecutive frequencies developing within 72 h, usually due to idiopathic causes.…”

Section: Introductionmentioning

confidence: 99%

Sudden sensorineural hearing loss after receiving an inactivated viral vaccine, Sinopharm: Two-case report

Asadi

Naderi

Jahanshahi

2023

SAGE Open Medical Case Reports

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The prevalence of Coronavirus Disease 2019 is a global threat. Due to the high mortality rate caused by this disease, the vaccination is mandatory to protect patients against it and reduce the mortality. Rapid development and widespread use of vaccines have raised the possibility of adverse side effects over the course of administration and follow-up. In this study, we investigated an adverse event of sudden sensorineural hearing loss in two patients receiving first dose of Sinopharm, an inactivated viral vaccine. Both patients experienced sudden hearing loss in their left ear some days after receiving the first dose of the Sinopharm and had normal otoscopic examinations in both ears and mild to severe sensorineural hearing loss was reported in the left ear. After imaging evaluation with magnetic resonance imaging which showed no pathologic points. Two patients were treated with prednisolone and valacyclovir. Both patients experienced response and had good prognosis in their follow-up. Our study showed that there is no direct evidence of an association between Coronavirus Disease 2019 vaccination. A viral infection can cause sudden sensorineural hearing loss and should be considered as a possible side effect after vaccination. Although the number of side effects reported in clinical trials has been very low, long-term follow-up of patients is needed to assess the vaccine’s safety, given the incidence of these cases.

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Audiovestibular and vaccination complications of COVID-19

Cited by 6 publications

References 68 publications

Audiovestibular adverse events following COVID-19 vaccinations

Audiovestibular adverse events following COVID-19 vaccinations

Long COVID and COVID-Induced Ménière's Disease: Overview and Recommendations

Sudden sensorineural hearing loss after receiving an inactivated viral vaccine, Sinopharm: Two-case report

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