Audit of the Physico-Chemical Quality of Amoxicillin Based Drugs Marketed in Senegal

Abstract

Non-compliant antibiotics pose problems of therapeutic efficacy at the level of the individual, but also a serious public health problem. The objective of our study was to evaluate the quality of generic amoxicillin (42 samples) by analytical methods in Dakar/Senegal. At 100% visual inspection of compliance; 100% compliance uniformity test; at the dissolution test all > 80% (86.8% to 108.8%). The presence of amoxicillin with the following contents: Tablets (95.2% to 104.1%); Capsules (91.5% to 113.9%) and Suspensions drinkable (96.9% -118.7%). All the samples in our study are 100% compliant according to the European and American pharmacopoeias (90% -120%). Other studies should therefore be oriented in the direction of stability as well as the dosage of degradation products.

The comparison of the quality of selected brands of antibiotics in Tanzania sourced from different geographical regions

“… 17 Similarly for amoxicillin capsules and ciprofloxacin tablets, even though some brands were significantly different from the reference brand on the amount of active pharmaceutical ingredients, due to the fact that all were within acceptable limits of the British Pharmacopoeia, therapeutic results may be guaranteed. 3 , 4 , 36 …”