Audit of the use of psoralen photochemotherapy (PUVA) and narrowband UVB phototherapy in the treatment of psoriasis

Yones, Sami Sasi; Palmer, Roy A.; Kuno, Yoshinori; Hawk, J.L.M.

doi:10.1080/09546630510033212

Cited by 10 publications

(9 citation statements)

References 5 publications

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“…Psoralen possesses photosensitizing, photobiological and phototherapeutic properties (Frank et al 1998). Psoralen has been used for the photochemotherapy of vitiligo and skin diseases such as psoriasis, mycosis fungoides and eczema (Pathak and Fitzpatrick 1992;Yones et al 2005). It was also found to exhibit anti-HIV activity (Zhou et al 2000;Shikishima et al 2001).…”

Section: Introductionmentioning

confidence: 95%

Effect of growth regulators on rapid micropropagation and psoralen production in Psoralea corylifolia L.

Baskaran

Jayabalan

2008

Acta Physiol Plant

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A rapid and efficient micropropagation system was developed for Psoralea corylifolia, an endangered, valuable medicinal plant. Multiple shoot buds were obtained in half-strength liquid Phillips-Collins (L2) medium supplemented with 5 lM benzylaminopurine (BA) and 5 lM thidiazuron (TDZ) from apical bud explants of 1-week-old cultures. The shoot buds were subcultured on enriched solid L2 medium supplemented with different concentrations and combinations of BA, kinetin (KIN), 2-isopentenyladenine (2iP), TDZ, bavistin (BVN) and trimethoprim (TMP). Enriched solid L2 medium supplemented with 2 lM BA, 1 lM TDZ and 100 mg l -1 BVN were more effective in producing greater number of shoots per explant (85.2 ± 0.9 shoots/explant) after 4 weeks of culture. The regenerated shoots (40-50 mm in length) rooted and accompanied by hardening upon transfer to 50 lM indole-3-butyric acid (IBA) for 15 min and followed by planting in sterile soil mixture and vermiculate (3:1 v/v), with 50 ml of one-eight strength L2 basal salt solution devoid of sucrose and inositol, supplemented with 5 lM IBA and 100 mg l -1 BVN. The plants achieved 100% rooting with hardening. Subsequently the rooted plants were successfully established in the field. The survival percentage differed with seasonal variations. The concentration of psoralen was evaluated in different tissues of ex vitro and in vivo grown plants by high-performance liquid chromatography (HPLC). Psoralen content was increased in leaves (2.97%), roots (2.38%), stems (5.40%) and seeds (1.63%) of ex vitro plants than the in vivo plants. This system facilitates for commercial and rapid propagation of P. corylifolia for conservation strategies and phytomedicine production.

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Section: Introductionmentioning

confidence: 95%

Effect of growth regulators on rapid micropropagation and psoralen production in Psoralea corylifolia L.

Baskaran

Jayabalan

2008

Acta Physiol Plant

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“…It produces various bioactive compounds such as coumarins, psoralen, isopsoralen, angelicin, daizein (Baskaran and Jayabalan 2007). Psoralen has been used for the photochemotherapy of vitiligo and skin diseases such as psoriasis, mycosis fungoides and eczema (Yones et al 2005). Psoralea corylifolia exhibits antitumour, antibacterial, antifungal and antioxidative activities and it is also used in curing stomach ache, anthelmintic, diuretic and diaphoretic in febrile conditions (see Jayabalan 2007, 2008).…”

Section: Introductionmentioning

confidence: 99%

Psoralen production in hairy roots and adventitious roots cultures of Psoralea coryfolia

Baskaran

Jayabalan

2009

Biotechnol Lett

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Psoralea corylifolia is an endangered plant producing various compounds of medical importance. Adventitious roots and hairy roots were induced in cultures prepared from hypocotyl explants. Psoralen content was evaluated in both root types grown either in suspension cultures or on agar solidified medium. Psoralen content was approximately 3 mg g(-1) DW in suspension grown hairy roots being higher than in solid grown hairy roots and in solid and suspension-grown adventitious roots.

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“…It produces various bioactive compounds such as coumarins, psoralen, angelicin and diazein (Baskaran and Jayabalan 2007). Psoralen has been used for the photochemotherapy of vitiligo and skin diseases such as psoriasis, mycosis, fungoides and eczema (Yones et al 2005). P. coryfolia exhibits antitumor, antibacterial, antifungal and antioxidative activities (Baskaran and Jayabalan 2007).…”

Section: Psoralea Coryfolia Lmentioning

confidence: 99%

Effect of PGRs in adventitious root culture in vitro: present scenario and future prospects

Ahmad

Fatima

Ahmad

et al. 2015

Rend. Fis. Acc. Lincei

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Plants, a source of undeviating therapeutic agents, are used as a model system for new synthetic compounds and a taxonomic marker for discovery of novel compounds. The expanding awareness of the health hazards and toxicity associated with the indiscriminate use of synthetic drugs has enhanced the interest in the use of plants and plant-based drugs. The evolving commercial significance of secondary metabolites in recent years has resulted in a great interest in secondary metabolism, particularly in the prospect of varying the production of bioactive plant metabolites by means of tissue culture technology. Adventitious root culture system (AR) provides an alternative approach for the improvement and enhancement of plant-based pharmaceutical compounds. AR serves as a base for conservation of important plant species by reducing pressure on its natural populations. The present review focuses on the application of plant growth regulators (particularly auxins and cytokinins) for the initiation and establishment of adventitious root cultures through various explants in vitro. The production of root biomass could provide bioactive compounds of interest in laboratory conditions. In addition, the root biomass production, accumulation and quantification of secondary metabolites studies in different medicinal plant species have been discussed in the light of different PGRs.

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Audit of the use of psoralen photochemotherapy (PUVA) and narrowband UVB phototherapy in the treatment of psoriasis

Cited by 10 publications

References 5 publications

Effect of growth regulators on rapid micropropagation and psoralen production in Psoralea corylifolia L.

Effect of growth regulators on rapid micropropagation and psoralen production in Psoralea corylifolia L.

Psoralen production in hairy roots and adventitious roots cultures of Psoralea coryfolia

Effect of PGRs in adventitious root culture in vitro: present scenario and future prospects

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