Auditory brain stem responses of kernicterus infants

Kaga, Kimitaka; Kitazumi, Eiji; Kodama, Kazuo

doi:10.1016/0165-5876(79)90020-x

Cited by 65 publications

(28 citation statements)

References 15 publications

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“…UCB was quickly shown to induce ABR changes that could progress to permanent signal loss or be reversed by exchange transfusion (52,53 ). There is now unequivocal evidence that UCB-induced ABR changes are predicted by B f but not B T in both premature and term newborns (54 -57 ).…”

Section: Where's the B F ? A Brief Clinical History Of Abe B T Andmentioning

confidence: 99%

Unbound (Free) Bilirubin: Improving the Paradigm for Evaluating Neonatal Jaundice

et al. 2009

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Background: The serum or plasma total bilirubin concentration (BT) has long been the standard clinical laboratory test for evaluating neonatal jaundice, despite studies showing that BT correlates poorly with acute bilirubin encephalopathy (ABE) and its sequelae including death, classical kernicterus, or bilirubin-induced neurological dysfunction (BIND). The poor correlation between BT and ABE is commonly attributed to the confounding effects of comorbidities such as hemolytic diseases, prematurity, asphyxia, or infection. Mounting evidence suggests, however, that BT inherently performs poorly because it is the plasma non–protein-bound (unbound or free) bilirubin concentration (Bf), rather than BT, that is more closely associated with central nervous system bilirubin concentrations and therefore ABE and its sequelae. Content: This article reviews (a) the complex relationship between serum or plasma bilirubin measurements and ABE, (b) the history underlying the limited use of Bf in the clinical setting, (c) the peroxidase method for measuring Bf and technical and other issues involved in adapting the measurement to routine clinical use, (d) clinical experience using Bf in the management of newborn jaundice, and (e) the value of Bf measurements in research investigating bilirubin pathochemistry. Summary: Increasing evidence from clinical studies, clinical experience, and basic research investigating bilirubin neurotoxicity supports efforts to incorporate Bf expeditiously into the routine evaluation of newborn jaundice. .

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Section: Where's the B F ? A Brief Clinical History Of Abe B T Andmentioning

confidence: 99%

Unbound (Free) Bilirubin: Improving the Paradigm for Evaluating Neonatal Jaundice

et al. 2009

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“…Note the partial reversal of the abnormal I-II latency beginning at 4 h that becomes statistically significant at 8 h. differential recordings both are followed by the largest negative trough of the BAEP, and both frequently appear as a smaller wave or plateau riding on the negative deflection of the previous wave (14). Therefore, the increased I-II and 1-111 IWI herein correspond to the increased 1-111 and I-V IWI in hyperbilirubinemic human newborns, and the decreased amplitudes of I1 and I11 in rats correspond to the decreased amplitudes of I11 and V in humans (24)(25)(26).…”

Section: Methodsmentioning

confidence: 99%

“…The similarity of Gunn rat BAEP abnormalities to those that occur in hyperbilirubinemic humans (14,15,22) further supports this as a good model for studying the neurophysiologic effects of bilirubin encephalopathy. The failure of bilirubin infusion alone to produce BAEP changes in adult normal rats (23) argues against this as a good model, inasmuch as BAEP changes do occur in human bilirubin encephalopathy (24)(25)(26).…”

Section: Methodsmentioning

confidence: 99%

Acute Brainstem Auditory Evoked Potential Abnormalities in Jaundiced Gunn Rats Given Sulfonamide

Shapiro

1988

Pediatr Res

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“…The changes are dependent on gestational and chronological age of the animal and appear to occur in the peripheral eighth nerve or cochlea as well as in brainstem pathways. Hearing loss occurs in about half of the infants surviving bilirubin encephalopathy (1), and the ABR measured months or years following the bilirubin injury is often absent or present only at increased stimulus intensity suggesting auditory nerve injury (2,3).…”

mentioning

confidence: 99%

Changes in the Auditory Brainstem Response Associated with Intravenous Infusion of Unconjugated Bilirubin into Infant Rhesus Monkeys

et al. 1986

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ABSTRACT'. The auditory brainstem response (ABR) was monitored in nine infant rhesus monkeys during the intravenous infusion of 50-168 mg/kg of unconjugated bilirubin. Sulfisoxazole (200 mg/kg) was sometimes given near the end of or just before the bilirubin infusion if no obvious ABR change had yet occurred. Five of the animals were term gestation, four were preterm, and they ranged from 1 to 40 days of age at the time of study. The three oldest term animals, studied at 20,35 and 40 days of age, respectively, showed variable changes in the ABR waves during bilirubin infusion and these changes were not altered further by sulfisoxazole administration. The other two term infants, studied at 1 and 6 days of age, respectively, showed sulfisoxazole enhanced ABR wave latency increase and amplitude reduction followed by loss of the ABR. Both of these animals became apneic following ABR loss and eventually died. The ABR reappeared in one animal prior to death. Minimal gross and microscopic changes were present in the brain of the 6-day-old animal at autopsy. The four preterm animals all had a progressive wave amplitude decrease followed by loss of the ABR with bilirubin alone. These preterm animals were sacrificed shortly after the ABR loss with only one showing yellow staining of the basal ganglia at autopsy. The infant rhesus monkey may be a useful paradigm for bilirubin-induced ototoxicity as manifested by potentially reversible ABR changes. The changes are dependent on gestational and chronological age of the animal and appear to occur in the peripheral eighth nerve or cochlea as well as in brainstem pathways. (Pediatr Res 20: 51 1-515, 1986) Abbreviation ABR, auditory brainstem response Hearing loss occurs in about half of the infants surviving bilirubin encephalopathy (1), and the ABR measured months or years following the bilirubin injury is often absent or present only at increased stimulus intensity suggesting auditory nerve injury (2, 3).Recent reports have documented a variety of acute, usually reversible ABR wave latency changes, amplitude changes, and

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Auditory brain stem responses of kernicterus infants

Cited by 65 publications

References 15 publications

Unbound (Free) Bilirubin: Improving the Paradigm for Evaluating Neonatal Jaundice

Unbound (Free) Bilirubin: Improving the Paradigm for Evaluating Neonatal Jaundice

Acute Brainstem Auditory Evoked Potential Abnormalities in Jaundiced Gunn Rats Given Sulfonamide

Changes in the Auditory Brainstem Response Associated with Intravenous Infusion of Unconjugated Bilirubin into Infant Rhesus Monkeys

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