Auditory brainstem responses in adults with autism spectrum disorder

Fujihira, Haruna; Itoi, Chihiro; Furukawa, Shigeto; Kato, Nobuo; Kashino, Makio

doi:10.1016/j.cnp.2021.04.004

Cited by 6 publications

(6 citation statements)

References 64 publications

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“…A recent study looking at newborns later diagnosed with ASD at the age of 3–5 years showed ABR latency delays (Delgado et al 2021 ), suggesting the emergence of differences in acoustic processing, at the brainstem level, right after birth. A more recent study tested adults with ASD and found no differences in absolute ABR wave latencies (Fujihira et al 2021 ). The authors showed a shorter summating potential (SP), suggesting normal auditory processing in the brainstem for ASD adults (Fujihira et al 2021 ).…”

Section: Results and Critical Discussionmentioning

confidence: 99%

“…A more recent study tested adults with ASD and found no differences in absolute ABR wave latencies (Fujihira et al 2021 ). The authors showed a shorter summating potential (SP), suggesting normal auditory processing in the brainstem for ASD adults (Fujihira et al 2021 ).…”

Section: Results and Critical Discussionmentioning

confidence: 99%

“…The authors showed a shorter summating potential (SP), suggesting normal auditory processing in the brainstem for ASD adults (Fujihira et al 2021 ).…”

Section: Results and Critical Discussionmentioning

confidence: 99%

“…By analyzing experimental designs, it is possible to see the wide variety of methods and protocols that are applied, even for similar techniques. For instance, some participants are allowed to sleep during ABR recordings (Fujihira et al 2021 ), while some participants watch videos during the experiment (Jones et al 2020 ; Chen et al 2019 ), creating different conditions to assess similar variables across studies. Another important consideration is medication status as an eligibility criterion for ASD studies.…”

Section: Final Remarksmentioning

confidence: 99%

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Autism Spectrum Disorder and auditory sensory alterations: a systematic review on the integrity of cognitive and neuronal functions related to auditory processing

Gonçalves

Monteiro

2023

J Neural Transm

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Autism Spectrum Disorder (ASD) is a neurodevelopmental condition with a wide spectrum of symptoms, mainly characterized by social, communication, and cognitive impairments. Latest diagnostic criteria according to DSM-5 (Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, 2013) now include sensory issues among the four restricted/repetitive behavior features defined as “hyper- or hypo-reactivity to sensory input or unusual interest in sensory aspects of environment”. Here, we review auditory sensory alterations in patients with ASD. Considering the updated diagnostic criteria for ASD, we examined research evidence (2015–2022) of the integrity of the cognitive function in auditory-related tasks, the integrity of the peripheral auditory system, and the integrity of the central nervous system in patients diagnosed with ASD. Taking into account the different approaches and experimental study designs, we reappraise the knowledge on auditory sensory alterations and reflect on how these might be linked with behavior symptomatology in ASD.

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Section: Results and Critical Discussionmentioning

confidence: 99%

Section: Results and Critical Discussionmentioning

confidence: 99%

“…The authors showed a shorter summating potential (SP), suggesting normal auditory processing in the brainstem for ASD adults (Fujihira et al 2021 ).…”

Section: Results and Critical Discussionmentioning

confidence: 99%

Section: Final Remarksmentioning

confidence: 99%

See 2 more Smart Citations

Autism Spectrum Disorder and auditory sensory alterations: a systematic review on the integrity of cognitive and neuronal functions related to auditory processing

Gonçalves

Monteiro

2023

J Neural Transm

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“…While ABRs have been used extensively to assess auditory brainstem physiology 17 and its abnormalities 18,19 , the capacity of ABRs to be modulated by pharmacological agents remains poorly understood. Therefore, we set out to test the effects of a wide range of pharmacological modulators on rodent ABRs.…”

Section: Introductionmentioning

confidence: 99%

Auditory brainstem responses are resistant to pharmacological modulation in Sprague Dawley wildtype and Neurexin1α knockout rats

Marashli

Janz

Redondo

2023

Preprint

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Sensory processing in the auditory brainstem can be studied with auditory brainstem responses (ABRs) across species. Although ABRs have been widely utilized to evaluate abnormalities in auditory brainstem physiology, there is limited understanding if ABRs can be useful tools to assess the effect of pharmacological interventions. Therefore, we set out to understand how pharmacological agents that target key transmitter systems of the auditory brainstem circuitry affect ABR physiology in rats. Given previous studies, demonstrating that Nrxn1α KO Sprague Dawley rats show substantial auditory processing deficits and altered sensitivity to GABAergic modulators, we used both Nrxn1α KO and wildtype littermates in our study. First, we probed how different commonly used anesthetics (isoflurane, ketamine/xylazine, medetomidine) affect ABRs waveforms. In the next step, we assessed the effects of different pharmacological compounds (diazepam, gaboxadol, retigabine, nicotine, baclofen, and bitopertin) either under isoflurane or medetomidine anesthesia. We found that under our experimental conditions, ABRs are largely unaffected by diverse pharmacological modulation. Significant modulation was observed with i.) nicotine, affecting the late ABR components at 90 dB stimulus intensity under isoflurane anesthesia in both genotypes and ii.) retigabine, showing a slight decrease in late ABRs deflections at 80 dB stimulus intensity, mainly in isoflurane-anesthetized Nrxn1α KO rats. Our study suggests that ABRs in anesthetized rats are resistant to a wide range of pharmacological modulators, which has important implications for the applicability of ABRs to study auditory brainstem physiology.

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How auditory processing influences the autistic profile: A review

Poulsen,

Williams,

Dwyer

et al. 2024

Autism Research

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We need to combine sensory data from various sources to make sense of the world around us. This sensory data helps us understand our surroundings, influencing our experiences and interactions within our everyday environments. Recent interest in sensory‐focused approaches to supporting autistic people has fixed on auditory processing—the sense of hearing and the act of listening—and its crucial role in language, communications, and social domains, as well as non‐social autism‐specific attributes, to understand better how sensory processing might differ in autistic people. In this narrative review, we synthesize published research into auditory processing in autistic people and the relationship between auditory processing and autistic attributes in a contextually novel way. The purpose is to understand the relationship between these domains more fully, drawing on evidence gleaned from experiential perspectives through to neurological investigations. We also examine the relationship between auditory processing and diagnosable auditory conditions, such as hyperacusis, misophonia, phonophobia, and intolerance to loud sounds, as well as its relation to sleep, anxiety, and sensory overload. Through reviewing experiential, behavioral and neurological literature, we demonstrate that auditory processes interact with and shape the broader autistic profile—something not previously considered. Through a better understanding of the potential impact of auditory experiences, our review aims to inform future research on investigating the relationship between auditory processing and autistic traits through quantitative measures or using qualitative experiential inquiry to examine this relationship more holistically.

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Auditory brainstem responses in adults with autism spectrum disorder

Cited by 6 publications

References 64 publications

Autism Spectrum Disorder and auditory sensory alterations: a systematic review on the integrity of cognitive and neuronal functions related to auditory processing

Autism Spectrum Disorder and auditory sensory alterations: a systematic review on the integrity of cognitive and neuronal functions related to auditory processing

Auditory brainstem responses are resistant to pharmacological modulation in Sprague Dawley wildtype and Neurexin1α knockout rats

How auditory processing influences the autistic profile: A review

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