Auditory Cortex Responsiveness During Talking and Listening: Early Illness Schizophrenia and Patients at Clinical High-Risk for Psychosis

Perez, Veronica B.; Ford, Judith M.; Roach, Brian J.; Loewy, Rachel; Stuart, Barbara; Vinogradov, Sophia; Mathalon, Daniel H.

doi:10.1093/schbul/sbr124

Cited by 66 publications

(68 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is consistent with our data showing that patients have less suppression to speech sounds during talking 11,12,14,15,17,19 and less neural activity preceding speech onset. 12 We have interpreted these data as reflecting failures of the corollary discharge and efference copy, respectively.…”

Section: Predictive Coding Failures In Schizophreniasupporting

confidence: 93%

“…Reduction of N1 during talking may reflect the action of the corollary discharge mechanism. Importantly, we have found that N1 suppression during talking is reduced in schizophrenia patients, 11,12,14,15,17,19 consistent with dysfunction of this predictive mechanism.…”

Section: Introductionsupporting

confidence: 72%

“…Data collected during our talking paradigm argue against this. First, we reported deficits in cortical suppression in clinical high-risk patients, not on medications, 15 and second, we see intermediate deficits in unmedicated first-degree relatives of psychotic patients. 19 While medications may not be responsible for our findings, medications may have undermined our ability to relate symptoms to our neurobiological measures.…”

Section: Predictive Coding Failures In Schizophreniamentioning

confidence: 68%

“…After ocular correction, data were baseline corrected again at −600 to −500 ms. Outlier electrodes were interpolated within single-trial epochs based on previously established criteria. 15,19,42 EEG epochs were artifact rejected for voltages exceeding ±100 μV at all scalp sites.…”

Section: Data Acquisition and Preprocessingmentioning

confidence: 99%

“…This is consistent with noninvasive, human electrophysiological studies employing electroencephalographic (EEG) or magnetoencephalographic (MEG) responses synchronized to vocalization onset. 11,12,14,15,17,19,[27][28][29] N1 of EEG-based event-related potentials (ERP) and M100 of MEG-based responses reveal increased activity in auditory areas during speaking, but the level of activity is lower during speaking than when recorded sounds are played back to the speaker. Reduction of N1 during talking may reflect the action of the corollary discharge mechanism.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Did I Do That? Abnormal Predictive Processes in Schizophrenia When Button Pressing to Deliver a Tone

Ford

Palzes

Roach

et al. 2013

Schizophrenia Bulletin

166

141

View full text Add to dashboard Cite

Motor actions are preceded by an efference copy of the motor command, resulting in a corollary discharge of the expected sensation in sensory cortex. These mechanisms allow animals to predict sensations, suppress responses to self-generated sensations, and thereby process sensations efficiently and economically. During talking, patients with schizophrenia show less evidence of pretalking activity and less suppression of the speech sound, consistent with dysfunction of efference copy and corollary discharge, respectively. We asked if patterns seen in talking would generalize to pressing a button to hear a tone, a paradigm translatable to less vocal animals. In 26 patients [23 schizophrenia, 3 schizoaffective (SZ)] and 22 healthy controls (HC), suppression of the N1 component of the auditory event-related potential was estimated by comparing N1 to tones delivered by button presses and N1 to those tones played back. The lateralized readiness potential (LRP) associated with the motor plan preceding presses to deliver tones was estimated by comparing right and left hemispheres' neural activity. The relationship between N1 suppression and LRP amplitude was assessed. LRP preceding button presses to deliver tones was larger in HC than SZ, as was N1 suppression. LRP amplitude and N1 suppression were correlated in both groups, suggesting stronger efference copies are associated with stronger corollary discharges. SZ have reduced N1 suppression, reflecting corollary discharge action, and smaller LRPs preceding button presses to deliver tones, reflecting the efference copy of the motor plan. Effects seen during vocalization largely extend to other motor acts more translatable to lab animals.

show abstract

Section: Predictive Coding Failures In Schizophreniasupporting

confidence: 93%

Section: Introductionsupporting

confidence: 72%

Section: Predictive Coding Failures In Schizophreniamentioning

confidence: 68%

Section: Data Acquisition and Preprocessingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Did I Do That? Abnormal Predictive Processes in Schizophrenia When Button Pressing to Deliver a Tone

Ford

Palzes

Roach

et al. 2013

Schizophrenia Bulletin

166

141

View full text Add to dashboard Cite

show abstract

Stability of mismatch negativity event‐related potentials in a multisite study

Roach¹,

Hamilton

Bachman

et al. 2020

Int J Methods Psych Res

View full text Add to dashboard Cite

ObjectivesMismatch negativity (MMN), an auditory event‐related potential sensitive to deviance detection, is smaller in schizophrenia and psychosis risk. In a multisite study, a regression approach to account for effects of site and age (12–35 years) was evaluated alongside the one‐year stability of MMN.MethodsStability of frequency, duration, and frequency + duration (double) deviant MMN was assessed in 167 healthy subjects, tested on two occasions, separated by 52 weeks, at one of eight sites. Linear regression models predicting MMN with age and site were validated and used to derive standardized MMN z‐scores. Variance components estimated for MMN amplitude and latency measures were used to calculate Generalizability (G) coefficients within each site to assess MMN stability. Trait‐like aspects of MMN were captured by averaging across occasions and correlated with subject traits.ResultsAge and site accounted for less than 7% of MMN variance. G‐coefficients calculated at electrode Fz were stable (G = 0.63) across deviants and sites for amplitude measured in a fixed window, but not for latency (G = 0.37). Frequency deviant MMN z‐scores averaged across tests negatively correlated with averaged global assessment of functioning.ConclusionMMN amplitude is stable and can be standardized to facilitate longitudinal multisite studies of patients and clinical features.

show abstract

Event Related Potential Studies and Findings: Schizophrenia as a Disorder of Cognition

Tang

Niznikiewicz

2020

Neuroimaging in Schizophrenia

View full text Add to dashboard Cite

Auditory Cortex Responsiveness During Talking and Listening: Early Illness Schizophrenia and Patients at Clinical High-Risk for Psychosis

Cited by 66 publications

References 32 publications

Did I Do That? Abnormal Predictive Processes in Schizophrenia When Button Pressing to Deliver a Tone

Did I Do That? Abnormal Predictive Processes in Schizophrenia When Button Pressing to Deliver a Tone

Stability of mismatch negativity event‐related potentials in a multisite study

Event Related Potential Studies and Findings: Schizophrenia as a Disorder of Cognition

Contact Info

Product

Resources

About