Auditory cortex shapes sound responses in the inferior colliculus

Blackwell, Jennifer M.; Lesicko, Alexandria M.H.; Rao, Winnie; Biasi, Mariella De; Geffen, Maria N.

doi:10.7554/elife.51890

Cited by 60 publications

(56 citation statements)

References 81 publications

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“…Therefore, bulk silencing may produce a mixture of effects that are difficult to interpret. More modern approaches using viralmediated delivery of optogenetic probes may solve some of these problems by permitting cell-type specific (Blackwell et al, 2020), layer-specific activation or silencing, and will permit activation or silencing to occur at the level of terminals, diminishing the likelihood of indirect effects stemming from changes in cochlear function.…”

Section: Methodological Issues In Top-down Modulation In the Subcortical Auditory Systemmentioning

confidence: 99%

“…The projections are tonotopic (Lim and Anderson, 2007;Markovitz et al, 2013;Barnstedt et al, 2015) and the inhibition is presumably at least disynaptic because the corticocollicular system is thought to be excitatory (Feliciano and Potashner, 1995), and the suppression occurs in the later phases of the response (Popeláˇr et al, 2015). Corticocollicular fibers are responsible for protean functions at the level of the inferior colliculus, including facilitating adaptive changes in inferior colliculus neurons (Zhang et al, 2005;Wu and Yan, 2007;Bajo et al, 2010;Robinson et al, 2016;Asokan et al, 2018), sharpening of frequency tuning (Blackwell et al, 2020) and elicitation of escape responses (Xiong et al, 2015).…”

Section: Evidence That Auditory Corticofugal Systems Engage In Predictive Codingmentioning

confidence: 99%

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Top-Down Inference in the Auditory System: Potential Roles for Corticofugal Projections

Asilador

Llano

2021

Front. Neural Circuits

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It has become widely accepted that humans use contextual information to infer the meaning of ambiguous acoustic signals. In speech, for example, high-level semantic, syntactic, or lexical information shape our understanding of a phoneme buried in noise. Most current theories to explain this phenomenon rely on hierarchical predictive coding models involving a set of Bayesian priors emanating from high-level brain regions (e.g., prefrontal cortex) that are used to influence processing at lower-levels of the cortical sensory hierarchy (e.g., auditory cortex). As such, virtually all proposed models to explain top-down facilitation are focused on intracortical connections, and consequently, subcortical nuclei have scarcely been discussed in this context. However, subcortical auditory nuclei receive massive, heterogeneous, and cascading descending projections at every level of the sensory hierarchy, and activation of these systems has been shown to improve speech recognition. It is not yet clear whether or how top-down modulation to resolve ambiguous sounds calls upon these corticofugal projections. Here, we review the literature on top-down modulation in the auditory system, primarily focused on humans and cortical imaging/recording methods, and attempt to relate these findings to a growing animal literature, which has primarily been focused on corticofugal projections. We argue that corticofugal pathways contain the requisite circuitry to implement predictive coding mechanisms to facilitate perception of complex sounds and that top-down modulation at early (i.e., subcortical) stages of processing complement modulation at later (i.e., cortical) stages of processing. Finally, we suggest experimental approaches for future studies on this topic.

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Section: Methodological Issues In Top-down Modulation In the Subcortical Auditory Systemmentioning

confidence: 99%

Section: Evidence That Auditory Corticofugal Systems Engage In Predictive Codingmentioning

confidence: 99%

Top-Down Inference in the Auditory System: Potential Roles for Corticofugal Projections

Asilador

Llano

2021

Front. Neural Circuits

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“…The anesthetized preparation was deemed appropriate for these experiments as contrast gain control in the auditory cortex (Rabinowitz et al 2011) and midbrain (Lohse et al 2020) has been found to be unaffected by anesthesia. Similarly, research into the role of PV interneuron activity is routinely investigated in both awake (e.g., Natan et al 2017) and anesthetized (e.g., Atallah et al 2012) preparations, and no difference between these conditions was reported in experiments in which the effects of optogenetic activation of PV interneurons on activity in auditory cortex was examined (Blackwell et al 2020). Finally, anesthesia was a constant factor across conditions and so should not have been a relevant variable for the between-condition changes observed here.…”

Section: Methodsmentioning

confidence: 99%

Contrast gain control occurs independently of both parvalbumin-positive interneuron activity and shunting inhibition in auditory cortex

Cooke

Kahn

Mann

et al. 2020

Journal of Neurophysiology

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We investigated whether contrast gain control is mediated by shunting inhibition from parvalbumin-positive interneurons in auditory cortex. We performed extracellular and intracellular recordings in mouse auditory cortex while presenting sensory stimuli with varying contrasts and manipulated parvalbumin-positive interneuron activity using optogenetics. We show that while parvalbumin-positive interneuron activity modulates the gain of cortical responses, this activity is not the primary mechanism for contrast gain control in auditory cortex.

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“…The projections are tonotopic (Lim and Anderson, 2007;Markovitz et al, 2013;Barnstedt et al, 2015) and the inhibition is presumably at least disynaptic because the corticocollicular system is thought to be excitatory (Feliciano and Potashner, 1995), and the suppression occurs in the later phases of the response (Popelář et al, 2015). Corticocollicular fibers have been found to be responsible for protean functions at the level of the inferior colliculus, including facilitating adaptive changes in inferior colliculus neurons (Zhang et al, 2005;Wu and Yan, 2007;Bajo et al, 2010;Robinson et al, 2016;Asokan et al, 2018), sharpening of frequency tuning (Blackwell et al, 2020) and elicitation of escape responses (Xiong et al, 2015).…”

Section: Evidence That Auditory Corticofugal Systems Engage In Predicmentioning

confidence: 99%

Top-down inference in the auditory system: Potential roles for corticofugal projections

Asilador¹,

Llano²

2020

Preprint

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It has become widely accepted that humans use contextual information to infer the meaning of ambiguous acoustic signals. In speech, for example, high-level semantic, syntactic or lexical information shape our understanding of a phoneme buried in noise. Most current theories to explain this phenomenon rely on hierarchical predictive coding models involving a set of Bayesian priors emanating from high-level brain regions (e.g., prefrontal cortex) that are used to influence processing at lower-levels of the sensory hierarchy (e.g., auditory cortex). As such, virtually all proposed models to explain top-down facilitation are focused on the cerebral cortex, and consequently subcortical nuclei have scarcely been discussed in this context. However, subcortical auditory nuclei receive massive, heterogeneous and cascading descending projections at every level of the sensory hierarchy, and activation of these systems has been shown to improve speech recognition. It is not yet clear whether or how top-down modulation to resolve ambiguous sounds calls upon these corticofugal projections. Here, we review the literature on top-down modulation in the auditory system, primarily focused on humans and cortical imaging/recording methods, and attempt to relate these findings to a growing animal literature, which has primarily been focused on corticofugal projections. We argue that corticofugal pathways contain the requisite circuitry to implement predictive coding mechanisms to facilitate perception of complex sounds and that top-down modulation at early stages of processing complements modulation at later (i.e., cortical) stages of processing. Finally, we suggest experimental approaches for future studies on this topic.

show abstract

Auditory cortex shapes sound responses in the inferior colliculus

Cited by 60 publications

References 81 publications

Top-Down Inference in the Auditory System: Potential Roles for Corticofugal Projections

Top-Down Inference in the Auditory System: Potential Roles for Corticofugal Projections

Contrast gain control occurs independently of both parvalbumin-positive interneuron activity and shunting inhibition in auditory cortex

Top-down inference in the auditory system: Potential roles for corticofugal projections

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