Auditory cortical generators of the Frequency Following Response are modulated by intermodal attention

Hartmann, Thomas; Weisz, Nathan

doi:10.1101/633834

2019

DOI: 10.1101/633834

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Auditory cortical generators of the Frequency Following Response are modulated by intermodal attention

Thomas Hartmann

Nathan Weisz

Abstract: 19The vast efferent connectivity of the auditory system suggests that subcortical 20 (thalamic and brainstem) auditory regions should also be sensitive to top-down processes 21 such as selective attention. In electrophysiology, the Frequency Following Response (FFR) 22

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Cited by 2 publications

References 89 publications

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Oscillatory entrainment of the Frequency Following Response in auditory cortical and subcortical structures

Coffey

Arseneau-Bruneau

Zhang

et al. 2020

Preprint

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There is much debate about the existence and function of neural oscillatory entrainment mechanisms in the auditory system. The frequency-following response (FFR) is an index of neural periodicity encoding that can provide a vehicle to study entrainment in frequency ranges relevant to speech and music processing. Criteria for entrainment include the presence of post-stimulus oscillations and phase alignment between stimulus and endogenous activity. To test the hypothesis of entrainment, in experiment 1 we collected FFR data to a repeated syllable using magneto- (MEG) and electroencephalography in 20 healthy adults. We observed significant oscillatory activity after stimulus offset in auditory cortex and subcortical auditory nuclei, consistent with entrainment. In these structures the FFR fundamental frequency converged from a lower value over 100 ms to the stimulus frequency, consistent with phase alignment, and diverged to a lower value after offset, consistent with relaxation to a preferred frequency. In experiment 2, we tested how transitions between stimulus frequencies affected the MEG-FFR to a train of pure-tone pairs in 30 adults. We found that the FFR was affected by the frequency of the preceding tone for up to 40 ms at subcortical levels, and even longer durations at cortical levels. Our results suggest that oscillatory entrainment may be an integral part of periodic sound representation throughout the auditory neuraxis. The functional role of this mechanism is unknown, but it could serve as a fine-scale temporal predictor for frequency information, enhancing stability and reducing susceptibility to degradation that could be useful in real-life noisy environments.

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Oscillatory entrainment of the Frequency Following Response in auditory cortical and subcortical structures

Coffey

Arseneau-Bruneau

Zhang

et al. 2020

Preprint

View full text Add to dashboard Cite

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The neural response to the temporal fine structure of continuous musical pieces is not affected by selective attention

Etard

Messaoud

Gaugain

et al. 2021

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Speech and music are spectro-temporally complex acoustic signals that a highly relevant for humans. Both contain a temporal fine structure that is encoded in the neural responses of subcortical and cortical processing centres. The subcortical response to the temporal fine structure of speech has recently been shown to be modulated by selective attention to one of two competing voices. Music similarly often consists of several simultaneous melodic lines, and a listener can selectively attend to a particular one at a time. However, the neural mechanisms that enable such selective attention remain largely enigmatic, not least since most investigations to date have focussed on short and simplified musical stimuli. Here we study the neural encoding of classical musical pieces in human volunteers, using scalp electroencephalography (EEG) recordings. We presented volunteers with continuous musical pieces composed of one or two instruments. In the latter case, the participants were asked to selectively attend to one of the two competing instruments and to perform a vibrato identification task. We used linear encoding and decoding models to relate the recorded EEG activity to the stimulus waveform. We show that we can measure neural responses to the temporal fine structure of melodic lines played by one single instrument, at the population level as well as for most individual subjects. The neural response peaks at a latency of 7.6 ms and is not measurable past 15 ms. When analysing the neural responses elicited by competing instruments, we find no evidence of attentional modulation. Our results show that, much like speech, the temporal fine structure of music is tracked by neural activity. In contrast to speech, however, this response appears unaffected by selective attention in the context of our experiment.

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Auditory cortical generators of the Frequency Following Response are modulated by intermodal attention

Abstract: 19The vast efferent connectivity of the auditory system suggests that subcortical 20 (thalamic and brainstem) auditory regions should also be sensitive to top-down processes 21 such as selective attention. In electrophysiology, the Frequency Following Response (FFR) 22

Cited by 2 publications

References 89 publications

Oscillatory entrainment of the Frequency Following Response in auditory cortical and subcortical structures

Oscillatory entrainment of the Frequency Following Response in auditory cortical and subcortical structures

The neural response to the temporal fine structure of continuous musical pieces is not affected by selective attention

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