Auditory ERPs to Stimulus Deviance in an Awake Chimpanzee (Pan troglodytes): Towards Hominid Cognitive Neurosciences

Ueno, Ari; Hirata, Satoshi; Fuwa, Kohki; Sugama, Keiko; Kusunoki, Kiyo; Matsuda, Goh; Fukushima, Hirokata; Hiraki, Kei; Tomonaga, Masaki; Hasegawa, Toshikazu

doi:10.1371/journal.pone.0001442

Cited by 41 publications

(48 citation statements)

References 22 publications

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“…Reliable MMN data that closely match MMNs recorded in humans have been recorded from rats 116, cats 117, chimpanzees 118, as well as monkeys 112. The results of these studies imply that animal models can be used to test newly developed pharmacological treatments to improve MMN in schizophrenia patients.…”

Section: Mismatch Negativitymentioning

confidence: 69%

Perception Measurement in Clinical Trials of Schizophrenia: Promising Paradigms From CNTRICS

Green

Butler

Chen

et al. 2009

Schizophrenia Bulletin

112

111

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The third meeting of the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS) focused on selecting promising measures for each of the cognitive constructs selected in the first CNTRICS meeting. In the domain of perception, the two constructs of interest were Gain Control and Visual Integration. CNTRICS received five task nominations for Gain Control and three task nominations for Visual Integration. The breakout group for perception evaluated the degree to which each of these tasks met pre-specified criteria. For Gain Control, the breakout group for perception believed that two of the tasks (Prepulse Inhibition of Startle and Mismatch Negativity) were already mature and in the process of being incorporated into multisite clinical trials. However, the breakout group recommended that Steady State Visual Evoked Potentials be combined with contrast sensitivity to magnocellular vs. parvocellular biased stimuli, and that this combined task and the Contrast-Contrast Effect Task be recommended for translation for use in clinical trial contexts in schizophrenia research. For Visual Integration, the breakout group recommended the Contour Integration and Coherent Motion tasks for translation for use in clinical trials. This manuscript describes the ways in which each of these tasks met the criteria used by the breakout group to evaluate and recommend tasks for further development.

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Section: Mismatch Negativitymentioning

confidence: 69%

Perception Measurement in Clinical Trials of Schizophrenia: Promising Paradigms From CNTRICS

Green

Butler

Chen

et al. 2009

Schizophrenia Bulletin

112

111

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“…While the chimpanzee brain has a structure comparable to that of humans, the shapes of the bone and muscles of the skull are substantially different to humans' [42]. Although a mismatch negativity was observed in the midline regions of the chimpanzee [28], this does not ensure that the other activity involved in generating human ERPs was also present in the chimpanzee ERPs. Thus, the apparent lack of an N170 in this study does not necessarily indicate major differences in the processing of faces between chimpanzees and humans.…”

Section: Discussion: Generalmentioning

confidence: 85%

Neural Correlates of Face and Object Perception in an Awake Chimpanzee (Pan Troglodytes) Examined by Scalp-Surface Event-Related Potentials

et al. 2010

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BackgroundThe neural system of our closest living relative, the chimpanzee, is a topic of increasing research interest. However, electrophysiological examinations of neural activity during visual processing in awake chimpanzees are currently lacking.Methodology/Principal FindingsIn the present report, skin-surface event-related brain potentials (ERPs) were measured while a fully awake chimpanzee observed photographs of faces and objects in two experiments. In Experiment 1, human faces and stimuli composed of scrambled face images were displayed. In Experiment 2, three types of pictures (faces, flowers, and cars) were presented. The waveforms evoked by face stimuli were distinguished from other stimulus types, as reflected by an enhanced early positivity appearing before 200 ms post stimulus, and an enhanced late negativity after 200 ms, around posterior and occipito-temporal sites. Face-sensitive activity was clearly observed in both experiments. However, in contrast to the robustly observed face-evoked N170 component in humans, we found that faces did not elicit a peak in the latency range of 150–200 ms in either experiment.Conclusions/SignificanceAlthough this pilot study examined a single subject and requires further examination, the observed scalp voltage patterns suggest that selective processing of faces in the chimpanzee brain can be detected by recording surface ERPs. In addition, this non-invasive method for examining an awake chimpanzee can be used to extend our knowledge of the characteristics of visual cognition in other primate species.

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“…NHP models are especially useful in the study of higher order sensory and cognitive deficits given the close relationship between humans and NHPs. There are several previous reports of MMN and "P3-like" components in a variety of primate species, including monkeys (16) and apes (33). For instance, Javitt et al (15), using epidural electrodes, recorded an MMN-like component from cynomolgus monkeys.…”

Section: Erp Measures Of Disrupted Sensory and Cognitive Function Inmentioning

confidence: 99%

Nonhuman primate model of schizophrenia using a noninvasive EEG method

Gil-da-Costa

Stoner

Fung

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

157

123

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There is growing evidence that impaired sensory-processing significantly contributes to the cognitive deficits found in schizophrenia. For example, the mismatch negativity (MMN) and P3a event-related potentials (ERPs), neurophysiological indices of sensory and cognitive function, are reduced in schizophrenia patients and may be used as biomarkers of the disease. In agreement with glutamatergic theories of schizophrenia, NMDA antagonists, such as ketamine, elicit many symptoms of schizophrenia when administered to normal subjects, including reductions in the MMN and the P3a. We sought to develop a nonhuman primate (NHP) model of schizophrenia based on NMDA-receptor blockade using subanesthetic administration of ketamine. This provided neurophysiological measures of sensory and cognitive function that were directly comparable to those recorded from humans. We first developed methods that allowed recording of ERPs from humans and rhesus macaques and found homologous MMN and P3a ERPs during an auditory oddball paradigm. We then investigated the effect of ketamine on these ERPs in macaques. As found in humans with schizophrenia, as well as in normal subjects given ketamine, we observed a significant decrease in amplitude of both ERPs. Our findings suggest the potential of a pharmacologically induced model of schizophrenia in NHPs that can pave the way for EEG-guided investigations into cellular mechanisms and therapies. Furthermore, given the established link between these ERPs, the glutamatergic system, and deficits in other neuropsychiatric disorders, our model can be used to investigate a wide range of pathologies.brain | psychiatry | neurology | monkey | medicine S chizophrenia is a multifaceted disorder that may originate from neuronal pathology in multiple brain systems (1). Current theories suggest that some of the sensory and cognitive symptoms of schizophrenia may, at least partially, result from dysfunction of the glutamate neurotransmitter system (2). In support of this theory, it has been found that acute subanesthetic doses of the N-methyl-D-aspartate receptor (NMDAR) antagonist ketamine induces sensory and cognitive deficits akin to those experienced by schizophrenia patients, as well as decreases of the mismatch negativity (MMN) and P3 event-related potential (ERP) amplitudes (3).The MMN is thought to reflect preattentive detection of a deviant stimulus (4), whereas the P3 is thought to reflect the redirection of attention to that deviant stimulus (5). In an oddball paradigm, responses to deviant (or "oddball") stimuli occurring among a sequence of standard stimuli are measured. The MMN is obtained by subtracting the ERP to the standard stimulus from the ERP to the deviant stimulus, whereas the P3a is typically observed in the ERP to deviants.Schizophrenia patients appear less able to detect and direct attention to novel stimuli than healthy controls (6). Consistent with this behavioral deficit, the amplitudes of both the MMN (7) and the P3 (8) have been found to be reduced in schizophrenia patients, l...

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Auditory ERPs to Stimulus Deviance in an Awake Chimpanzee (Pan troglodytes): Towards Hominid Cognitive Neurosciences

Cited by 41 publications

References 22 publications

Perception Measurement in Clinical Trials of Schizophrenia: Promising Paradigms From CNTRICS

Perception Measurement in Clinical Trials of Schizophrenia: Promising Paradigms From CNTRICS

Neural Correlates of Face and Object Perception in an Awake Chimpanzee (Pan Troglodytes) Examined by Scalp-Surface Event-Related Potentials

Nonhuman primate model of schizophrenia using a noninvasive EEG method

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