Auditory event-related potentials during target detection are abnormal in mild cognitive impairment

Golob, Edward J.; Johnson, Julene K.; Starr, Arnold

doi:10.1016/s1388-2457(01)00713-1

Cited by 135 publications

(98 citation statements)

References 61 publications

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“…As in previous cued attention studies, both groups showed cueing effects (Posner, 1980;Hartley et al, 1990;Golob et al, 2002a). Reaction times were shortest for valid trials, intermediate for neutral trials, and longest for invalid trials.…”

Section: Behavioral Resultssupporting

confidence: 83%

Age-related differences in auditory event-related potentials during a cued attention task

Bennett¹,

Golob²,

Starr³

2004

Clinical Neurophysiology

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Objective: To determine if aging is associated with differences in attentional regulation using behavioral and event-related potential (ERP) measures.Methods: Younger (n ¼ 13; M ¼ 20 years) and older (n ¼ 12; M ¼ 76 years) subjects performed an auditory cued attention task. Verbal cues correctly (valid) or incorrectly (invalid) predicted the ear receiving a target tone 1.5 s later, or were uninformative (neutral). Targets were either 'high' (2000 Hz) or 'low' (1000 Hz) pitch monaural tones. Subjects pressed one of 4 buttons to indicate target ear and pitch. ERPs following cues and targets (P50, N100, P200, slow waves), and negative slow potentials (CNV) between cues and targets were assessed.Results: Cue information had significant effects on reaction time for both groups (valid , neutral , invalid). Target N100 amplitude was significantly affected by cueing in younger (invalid . valid) but not older subjects. Target slow waves were also affected by cue information (invalid . valid), and the difference was larger and lasted longer in older subjects. Slow waves following cues were significantly larger in older subjects, but the subsequent CNV amplitudes were comparable among groups.Conclusions: When performing a cued attention task, age differences are present in transient ERPs following cues and targets. Significance: Age differences in ERPs associated with attentional regulation support the hypothesis that attentional changes contribute to cognitive aging.

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Section: Behavioral Resultssupporting

confidence: 83%

Age-related differences in auditory event-related potentials during a cued attention task

Bennett¹,

Golob²,

Starr³

2004

Clinical Neurophysiology

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“…The differences between the recovery functions of P50 and N100 in MCI may be due to different generator sites in auditory cortex (Liegeois-Chauvel et al, 1994;Onitsuka et al, 2000;Reite et al, 1988;Yoshiura et al, 1995) and/or to changes in connectivity specific to the N100 generator (Chao and Knight, 1998). There were no significant group effects for the P200 component, a result consistent with previous studies (Golob et al, 2001(Golob et al, , 2002.…”

Section: Rate Effects Of Long-latency Evoked Potentialssupporting

confidence: 88%

“…Large long-latency P50 amplitudes in MCI were also observed in previous studies using both an auditory target detection task (stimulus rate 1/2.5 s) (Golob et al, 2002) and when passively listening to stimulus pairs (600 ms inter-stimulus interval, 9.4 s inter-pair interval) (Golob et al, 2001). Asymptomatic family members of Alzheimer's disease patients, who also have an increased risk of Alzheimer's disease, have significantly larger P50 amplitudes in auditory target detection task (Boutros et al, 1995).…”

Section: Rate Effects Of Long-latency Evoked Potentialssupporting

confidence: 82%

“…We attribute the borderline significance in this latter analysis to the small number of MCI subjects studied (nZ8). In support of this possibility a previous study of a larger number of MCI (nZ15) with a stimulus rate at 1/2.5 s showed significantly increased amplitudes of long-latency P50 component for MCI compared to controls (Golob et al, 2002). Group differences in N100 amplitudes depended on stimulus rate, with larger amplitudes in MCI at slower presentation rate (1/1.5 s), but comparable amplitudes at the fastest rate (2/s).…”

Section: P50 Amplitude In MCI With Neuropsychological and Demographicmentioning

confidence: 59%

“…A previous study in MCI using auditory long-latency cortical potentials in a target detection, or 'oddball' task, demonstrated an increased amplitude and delayed latency Clinical Neurophysiology 116 (2005) for a component having a peak latency of w50 ms (P50) (Golob et al, 2002). P50 amplitude increases in MCI are not specific to the use of an auditory discrimination task as P50 amplitudes are also increased relative to controls when passively listening to tones (Golob et al, 2001).…”

Section: Introductionmentioning

confidence: 94%

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Auditory brain-stem, middle- and long-latency evoked potentials in mild cognitive impairment

Irimajiri

Golob

Starr

2005

Clinical Neurophysiology

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Objective: Mild cognitive impairment (MCI) is a selective episodic memory deficit in the elderly with a high risk of Alzheimer's disease. The amplitudes of a long-latency auditory evoked potential (P50) are larger in MCI compared to age-matched controls. We tested whether increased P50 amplitudes in MCI were accompanied by changes of middle-latency potentials occurring around 50 ms and/or auditory brainstem potentials. Methods: Auditory evoked potentials were recorded from age-matched controls (nZ16) and MCI (nZ17) in a passive listening paradigm at two stimulus presentation rates (2/s, 1/1.5 s). A subset of subjects also received stimuli at a rate of 1/3 s. Results: Relative to controls, MCI subjects had larger long-latency P50 amplitudes at all stimulus rates. Significant group differences in N100 amplitude were dependent on stimulus rate. Amplitudes of the middle-latency components (Pa, Nb, P1 peaking at approximately 30, 40, and 50 ms, respectively) did not differ between groups, but a slow wave between 30 and 49 ms on which the middle-latency components arose was significantly increased in MCI. ABR Wave V latency and amplitude did not differ significantly between groups. Conclusions: The increase of long-latency P50 amplitudes in MCI reflects changes of a middle-latency slow wave, but not of transient middle-latency components. There was no evidence of group difference at the brain-stem level. Significance: Increased slow wave occurring as early as 50 ms may reflect neurophysiological consequences of neuropathology in MCI.

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Using EEG and MEG to Understand Brain Physiology in Alzheimer's Disease and Related Dementias

Ally

2011

The Handbook of Alzheimer's Disease and Other Dementias

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Auditory event-related potentials during target detection are abnormal in mild cognitive impairment

Cited by 135 publications

References 61 publications

Age-related differences in auditory event-related potentials during a cued attention task

Age-related differences in auditory event-related potentials during a cued attention task

Auditory brain-stem, middle- and long-latency evoked potentials in mild cognitive impairment

Using EEG and MEG to Understand Brain Physiology in Alzheimer's Disease and Related Dementias

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