Auditory event-related potentials in separating patients with depressive disorders and non-depressed controls: A narrative review

Kangas, Elina S.; Vuoriainen, Elisa; Lindeman, Sari; Astikainen, Piia

doi:10.1016/j.ijpsycho.2022.07.003

Cited by 18 publications

(9 citation statements)

References 214 publications

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“…A recent narrative review by Kangas et. al stated that LDAEP studies have generally yielded no consistent difference between depressed and non-depressed controls, though there appears to be a relationship with depression-subtypes (18). Given this context, a possible explanation for our results not supporting the original hypothesis could be that the LDAEP does not precisely mirror serotonergic tone in the primary auditory cortex.…”

Section: Discussionmentioning

confidence: 99%

“…An abundance of literature now exists exploring the relationship between the LDAEP and other neurotransmitter systems and biomarkers (18, 19). While evidence for the LDAEP’s relationship with serotonin is controversial, it is clear serotonergic activity serves a critical role in the functioning of the primary auditory cortex (18, 20, 21, 22, 23, 24). Numerous studies provide robust support for the influence of serotonergic activity on neuronal functioning across auditory processing pathways (25, 26, 27, 28).…”

Section: Introductionmentioning

confidence: 99%

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Electroconvulsive Therapy Modulates Loudness Dependence of Auditory Evoked Potentials: A Pilot MEG Study

Dib,

Lewine,

Abbott

et al. 2024

Preprint

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Electroconvulsive therapy (ECT) remains a critical intervention for treatment-resistant depression (MDD), yet its neurobiological underpinnings are not fully understood. This pilot study utilizes high-resolution magnetoencephalography (MEG) in nine depressed patients receiving right unilateral ECT, to investigate the changes in loudness dependence of auditory evoked potentials (LDAEP), a proposed biomarker of serotonergic activity, following ECT. We hypothesized that ECT would reduce the LDAEP slope, reflecting enhanced serotonergic neurotransmission. Contrary to this, our findings indicated a significant increase in LDAEP post-ECT (t_8 = 3.17, p = .013). The increase in LDAEP was not associated with changes in depression severity or cognitive performance, as assessed by the Hamilton Depression Rating Scale (HAMD-24) and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). We discussed potential mechanisms for the observed increase, including ECT's impact on serotonergic, dopaminergic, glutamatergic, and GABAergic receptor activity, neuroplasticity involving brain-derived neurotrophic factor (BDNF), and inflammation modulators such as TNF-alpha. Our results suggest a complex interaction between ECT and these neurobiological systems, rather than a direct reflection of serotonergic neurotransmission.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Electroconvulsive Therapy Modulates Loudness Dependence of Auditory Evoked Potentials: A Pilot MEG Study

Dib,

Lewine,

Abbott

et al. 2024

Preprint

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“…an enhanced response specifically to sad faces) commonly reported in early sensory ERP responses in previous depression studies (Dai & Feng, 2012; Ruohonen et al, 2020; Xu et al, 2018; Zhang et al, 2016; Zhao et al, 2015). Thus, even though pain and depression are commonly co‐morbid, and even though chronic pain patients (Dick et al, 2006; Yao et al, 2011) and neuropsychiatric patients (for reviews, see Kangas et al, 2022; Toshihiko Maekawa et al, 2012) display some similar anomalies in task‐irrelevant auditory processing, visual face processing may not be similarly affected in acute pain and depression.…”

Section: Discussionmentioning

confidence: 99%

Pain modulates early sensory brain responses to task‐irrelevant emotional faces

et al. 2023

European Journal of Pain

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Pain can significantly impact our lives, and it has both cognitive and affective consequences for individuals. Nevertheless, our understanding of the effects of pain on social cognition remains limited. We investigated how pain affected the perception of facial emotions by recording brain responses to task-irrelevant faces in healthy participants. Event-related potentials (ERPs), which can reveal the time course of brain activity, were measured in response to neutral, sad, and happy faces prior to, during, and after a cold pressor pain. Early ERPs (P1, N170, and P2) reflecting early visual processing were analyzed. Pain significantly decreased the P1 amplitude to happy faces and increased the N170 amplitude to happy and sad faces compared to the pre-pain phase. The effect of pain on N170 was also observable in the post-pain phase. No effect of pain on face perception was found for the P2 component. These results suggest that pain alters feature and structure encoding of emotional faces even when they are task irrelevant. Further research is required to investigate how pain alters other aspects of social cognition, such as face perception in social interactions.

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“…The first characteristic is reduced glutamate synaptic efficacy as reflected in reduced amplitude of sensory evoked potentials ( 36 ) and in reduced cortical functional connectivity ( 23 ). Also, a recent study in PTSD with or without comorbid major depression ( 37 ) reported reduced synaptic strength as reflected by reduced “energy per cycle,” i.e., decreased metabolic activity (tricarboxylic acid cycle activity) per each molecule of glutamate released by neurons.…”

Section: The Neurobiology Of Depression: Beyond the Monoamine Hypothesismentioning

confidence: 99%

Ketamine and the neurobiology of depression: Toward next-generation rapid-acting antidepressant treatments

Krystal,

Kaye,

Jefferson

et al. 2023

Proc. Natl. Acad. Sci. U.S.A.

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Ketamine has emerged as a transformative and mechanistically novel pharmacotherapy for depression. Its rapid onset of action, efficacy for treatment-resistant symptoms, and protection against relapse distinguish it from prior antidepressants. Its discovery emerged from a reconceptualization of the neurobiology of depression and, in turn, insights from the elaboration of its mechanisms of action inform studies of the pathophysiology of depression and related disorders. It has been 25 y since we first presented our ketamine findings in depression. Thus, it is timely for this review to consider what we have learned from studies of ketamine and to suggest future directions for the optimization of rapid-acting antidepressant treatment.

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Auditory event-related potentials in separating patients with depressive disorders and non-depressed controls: A narrative review

Cited by 18 publications

References 214 publications

Electroconvulsive Therapy Modulates Loudness Dependence of Auditory Evoked Potentials: A Pilot MEG Study

Electroconvulsive Therapy Modulates Loudness Dependence of Auditory Evoked Potentials: A Pilot MEG Study

Pain modulates early sensory brain responses to task‐irrelevant emotional faces

Ketamine and the neurobiology of depression: Toward next-generation rapid-acting antidepressant treatments

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