Auditory evoked cortical responses to frequency glides in subjects with retrocochlear hearing impairment.

Arlinger, Stig

doi:10.1136/jnnp.46.10.917

Cited by 9 publications

(1 citation statement)

References 12 publications

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“…The result was considered abnormal if the 190 value exceeded 167ms for the 50-Hz glides and/or 140 ms for the 2oo-Hz glides. The normal reference group comprised 44 subjects aged 15-73 (mean 54) years (9).…”

Section: Otoneurological Test Batterymentioning

confidence: 99%

Otoneurological findings in workers exposed to styrene.

Möller

Ödkvist²,

Larsby³

et al. 1990

Scand J Work Environ Health

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MOLLER C, ODKVIST L, LARSBY B, THAM R, LEDIN T, BERGHOLTZ L. Otoneurological findings in workers exposed to styrene. Scand J Work Environ Health 1990;16:189-94. An otoneurological test battery was adm inistered to 18 workers with long-term exposure (6-15 years) to styrene at levels well below the current Swedish limit (110 mg/m'). The results were compared with those of a reference gro up. Disturbances were found in the centr al auditory path ways of seven wor kers. Tests reflecting central pr ocessing of impu lses from different sensory equilib rium organs were abnormal for 16 workers. Th e most relevant tests seemed to be static posturography and the rotatory visual suppression test. In the posturograph y the styrene gro up had a significantl y larger sway area than the reference group. In the visual suppression test , the styrene workers displayed a significantly poorer abilit y to suppress vestibular nystagmus than the reference group. It was concluded that styrene exposur e in industrial environments at moderate or low levels causes central nervous system disturbances which ar e not always diagnosable with psychometric tests but can be apparent in special otoneurological tests.

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Section: Otoneurological Test Batterymentioning

confidence: 99%

Otoneurological findings in workers exposed to styrene.

Möller

Ödkvist²,

Larsby³

et al. 1990

Scand J Work Environ Health

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Audiological Disturbances Caused by Long-term Exposure to Industrial Solvents. Relation to the Diagnosis of Toxic Encephalopathy

Niklasson¹,

Arlinger²,

Ledin³

et al. 1998

Scandinavian Audiology

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Sixty workers, consecutively admitted due to suspicion of solvent-induced chronic toxic encephalopathy (CTE), were investigated with pure-tone audiometry, determination of speech recognition of monosyllabic words and distorted speech and cortical response audiometry (CRA). Eighteen workers not exposed to occupational solvents and noise were also investigated. The scores in the distorted speech test were significantly lower and the CRA latencies were significantly longer in the solvent group than in the control group. There was no difference between the groups in the pure-tone and monosyllabic speech recognition tests. In the solvent group, 19 subjects had one or several pathological audiological test results (values exceeding the mean result of the control group by 2 SD). Independently of the audiological examination all the workers in the solvent group underwent the traditional clinical assessment of CTE, which is based on symptoms, history of exposure, clinical neurological examination and a neuropsychological investigation. They were classified in three groups--CTE, incipient CTE and non-CTE. There was no correlation between these groups and the audiological test results. A previous report on vestibular pathology in the same group of subjects and the present investigation on hearing deficits suggest that long-term exposure to solvents causes disturbances of the central pathways in the otovestibular system. Hitherto, no attention has been paid to these disturbances in the definition of the CTE syndrome.

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Otoneurologic Disturbances Caused by Solvent Pollution

Ödkvist¹,

Möller²,

Thuomas³

1992

Otolaryngol.--head neck surg.

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Subjects exposed to industrial solvents may experience vertigo and nausea. Solvents are usually volatile hydrocarbon compounds, which are important parts of everyday life in a modern society. They may also cause neurastenia, personality changes, and reduced intellectual capacity. The syndrome that may develop was formerly named psycho-organic syndrome (POS), but in modern terminology it is called chronic toxic encephalopathy (CTE). The syndrome develops slowly, and during the first years no pathological findings will be found using various test batteries. Somewhat later, when the syndrome still might be reversible, psychometric, auditory, and otoneurologic testing may well unveil disturbances within the posterior fossa structures. Animal experiments suggest one site of effect for solvents to be within the cerebellum and brainstem regions with close relationship to the gamma-amino-butyric acid (GABA) transmission. In the otoneurologic test battery, visual suppression and smooth pursuit are of extreme value, as are some auditory tests such as discrimination of interrupted speech and cortical response audiometry using frequency glides as stimuli. Dynamic posturography and magnetic resonance imaging (MRI) have recently proved valuable in the diagnosis. Research is needed concerning the most efficient test battery for early detection of solvent-induced lesions. During further research it is important to unveil other toxic agents, like heavy metals and alcohol, and their damage to the central nervous system and to make comparisons between these substances and the lesions caused by hydrocarbon solvents.

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Auditory evoked cortical responses to frequency glides in subjects with retrocochlear hearing impairment.

Cited by 9 publications

References 12 publications

Otoneurological findings in workers exposed to styrene.

Otoneurological findings in workers exposed to styrene.

Audiological Disturbances Caused by Long-term Exposure to Industrial Solvents. Relation to the Diagnosis of Toxic Encephalopathy

Otoneurologic Disturbances Caused by Solvent Pollution

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