Auditory Evoked Potentials and Psychopathology

Lifshitz, Kenneth; Susswein, Samuel; Lee, Kai

doi:10.1007/978-1-4684-3462-0_18

Cited by 13 publications

(8 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several studies resulted in differences between the sensory evoked cortical potentials of schizophrenic patients and healthy controls. Amplitude values of auditory evoked potentials (AEP) were found to be diminished in schizophrenie patients (Iones et al , 1965;Iones and Callaway 1970;Saletu et al, 1971Saletu et al, a, 1973Roth and Cannon, 1972;Shagass et al, 1977;Lifshitz et al, 1979;Roth et al, 1980). Shorter latency measures were also reported (Saletu et al, 1971a;Shagass et al, 1977).…”

Section: Introductionmentioning

confidence: 99%

Schizophrenia, Psychoticism, Neuroleptics, and Auditory Evoked Potentials

Kh¹,

Hw²,

Haas³

et al. 1985

Pharmacopsychiatry

View full text Add to dashboard Cite

Auditory cortical evoked potentials of 20 schizophrenic patients with an acute exacerbation of the illness were investigated before neuroleptic medication and after remission of the acute symptoms, and compared with healthy controls matched for sex and age. Additionally, tests were conducted in 40 healthy volunteers to ascertain whether psychoticism or other personality factors were correlated with evoked potentials. The aim of the study was to test the overarousal hypothesis of schizophrenia and to control the effects of clinical state, neuroleptic medication and personality factors. Acutely ill schizophrenic patients had a shorter evoked potential N1 latency (Table 1). After remission of the symptoms under haloperidol N1 latency of the patients was no longer different from that of the controls. Patients after remission and on medication, however, had longer P2 and N2 latencies and a greater P2-N2 amplitude (Table 2). Psychoticism and extraversion were correlated negatively with amplitude data of components N1 and P2 in healthy volunteers. The results favor the overarousal hypothesis of schizophrenia. Haloperidol normalizes N1 latency in acutely ill patients. It's effect on later components of the evoked potentials seems comparable to a reduction in vigilance. Auditory evoked potentials might allow to follow up the effect of neuroleptics in acute schizophrenia. It seems necessary to consider personality factors when comparing patients with healthy controls in evoked potential studies.

show abstract

Section: Introductionmentioning

confidence: 99%

Schizophrenia, Psychoticism, Neuroleptics, and Auditory Evoked Potentials

Kh¹,

Hw²,

Haas³

et al. 1985

Pharmacopsychiatry

View full text Add to dashboard Cite

show abstract

“…A further issue that merits discussion is the exact nature of the data set used to estimate the amount of drift and the quantity of data to be included in this set. The procedure described in the present paper suggests the reliance on prestimulus data and differs in this regard from the procedure described by Lifshitz et al (1979), who include both prestimulus and poststimulus data points. The consequences of this choice will vary to some extent with the exact nature of both prestimulus and poststimuius data, but as a rule the inclusion of only prestimulus information is to be preferred.…”

Section: Discussionmentioning

confidence: 99%

“…This is analogous to a time constant setting of approximately 4 sec. While there is little doubt that the procedure eliminated prestimulus drift, it is also likely that it attenuated the slow wave response which developed during the long interstimulus interval (8 sec) they were investigating, Klorman (1975), Buchsbaum and Coppola (1974), and Lifshitz, Susswein, and Lee (1979) have ail reported variations on a regression procedure which they used to eliminate statistically the contamination due to baseline drift. Unfortunately.…”

mentioning

confidence: 99%

“…It is an improvement over other techniques in which the decision to correct is based solely on visual inspection of each trial (Weerts & Lang, 1973). or techniques which correct every trial as a matter of course (Lifshitz et al, 1979). The present method of drift correction assumes that drift present during a prestimulus epoch will continue following stimulus onset and will contribute to the extracted response waveform.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Correcting Baseline Drift Artifact in Slow Potential Recording

Simons

Miller²,

Weerts

et al. 1982

Psychophysiology

View full text Add to dashboard Cite

A problem frequently encountered by investigators measuring scalp‐recorded DC potentials is baseline drift artifact. The sources of baseline drift are many and it is often very difficult to remove drift from the primary data. The problem is particularly acute when long recording epochs are under investigation. The present paper proposes a software solution. A FORTRAN IV computer program defines drift as a significant linear trend in prestimulus voltage on successive experimental trials. When drift is determined to be present, its slope is computed and statistically removed from the data in the poststimulus (response) period. A sample data set is included which demonstrates the method's marked improvement of signal‐to‐noise ratios, as represented by reduced error variance and improved statistical discrimination between the independent variables of an experiment.

show abstract

“…The AEP may also be affected by the interaction of time and medication. For example, in a cross-sectional study Lifshitz et al [ 10] report that the length of time that a psychoactive drug is administered may affect the AEP, as may the length of time of withdrawal. …”

mentioning

confidence: 99%

Long-Term Replicability of EEG Spectra and Auditory Evoked Potentials in Schizophrenic and Normal Subjects

Lifshitz¹,

Lee²,

Susswein³

1987

Neuropsychobiology

Self Cite

View full text Add to dashboard Cite

The spectral characteristics and average, auditory evoked potentials (AEPs) were determined from EEGs repeatedly recorded over a span of several years. Data from a vertex lead is presented for 4 chronic schizophrenic patients and 5 normal subjects. Measurements were made under identical conditions. For each subject characteristic spectra and AEPs were exhibited despite the passage of time. Patients had recordings performed both on and off antipsychotic medication. While receiving antipsychotic medication the patients’ EEG spectra showed an increase in alpha activity. Less consistently there was a decrease in delta or an increase in beta activity; theta activity was unchanged. These latter effects are different from those generally reported for an acute antipsychotic dose and may be more representative of antipsychotic effects (which occur after days or weeks of treatment). Psychopathology tended to be inversely related to alpha power, the magnitude of the AEP N100, and medication.

show abstract

Auditory Evoked Potentials and Psychopathology

Cited by 13 publications

References 23 publications

Schizophrenia, Psychoticism, Neuroleptics, and Auditory Evoked Potentials

Schizophrenia, Psychoticism, Neuroleptics, and Auditory Evoked Potentials

Correcting Baseline Drift Artifact in Slow Potential Recording

Long-Term Replicability of EEG Spectra and Auditory Evoked Potentials in Schizophrenic and Normal Subjects

Contact Info

Product

Resources

About