Auditory Evoked Potentials During Propofol Anaesthesia in Man

Chassard, D.; Colson, Amy E.; Banssillon, V.; Joubaud, A.; Dubreuil, C.; Guiraud, Michel

doi:10.1093/bja/62.5.522

Cited by 38 publications

(13 citation statements)

References 26 publications

(29 reference statements)

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“…The AEP results observed in this study are in agreement with data from studies in humans, which showed dose‐dependent effects upon the AEP with propofol alone (Chassard et al. , 1989; Tooley et al.…”

Section: Discussionsupporting

confidence: 91%

Effects of different propofol infusion rates on EEG activity and AEP responses in rats

Antunes

Roughan

Flecknell

2003

Vet Pharm & Therapeutics

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Parameters calculated from the auditory-evoked potential (AEP) recorded over the auditory cortex and from the electroencephalogram (EEG) recorded over the near vertex were compared in rats at three different infusion rates of propofol (62.5, 35 and 25 mg/kg/h). Depth of anaesthesia was assessed clinically using the strength of the pedal withdrawal reflex. Well-defined AEP responses were consistently obtained. As the propofol concentration was reduced, peak latencies decreased and peak to peak amplitudes increased. Amplitude and latency values were closely associated with the strength of the pedal withdrawal responses. Parameters calculated from the EEG showed no significant change as the propofol concentration was reduced. Periods of burst suppression became more frequent as the propofol infusion rate was increased. The study showed some of the difficulties that may be encountered when using EEG as a tool to assess depth of anaesthesia during propofol infusion. The AEP showed dose dependent changes in rats at different infusion rates of propofol. However, large variability between animals limits the use of this technique for monitoring depth of anaesthesia.

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Section: Discussionsupporting

confidence: 91%

Effects of different propofol infusion rates on EEG activity and AEP responses in rats

Antunes

Roughan

Flecknell

2003

Vet Pharm & Therapeutics

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“…The statistical test here compares the P K value with 0.50, which is the P K value that represents no association P K for VRS P K for OAA=S score P K for BIS Block p level 0.747 * 0.748 * 0.594 * Block t level 0.670 * 0.662 * 0.507 BIS 0.662 * 0.728 * - Sedation during epidural anaesthesia circuits in the brainstem interact with reticular nuclei providing the anatomical basis for the defence alertness reaction, sensory information control, and even sleep regulation. 17 18 Taken into account the very limited BAEP response to general anaesthetics, [22][23][24][25] even at anaesthetic depths associated with EEG burst suppression, 30 believe that the significant correlation of sensory block with the latency of brainstem potential III involves a selective effect of sensory deafferentation on the activity of the midbrain region inside and in the vicinity of inferior colliculus. Despite the fact that sensory input (including auditory stimulation) from the unblocked areas of the body might have counteracted any deafferentation effect on BAEP in unmedicated volunteers, brainstem conduction showed a significant positive correlation with the block level and sedation depth.…”

Section: Discussionmentioning

confidence: 99%

Block-dependent sedation during epidural anaesthesia is associated with delayed brainstem conduction

Doufas

Wadhwa

Shah

et al. 2004

British Journal of Anaesthesia

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“…Because propofol has been reported to suppress markedly the AEP [26], BIS [27], SEF [5] and MF [6] in dose-dependent fashion, changes in propofol blood concentration, especially its protein unbinding fraction, should affect the results. In the present study, the mean target propofol blood concentration was managed within a narrow range.…”

Section: Discussionmentioning

confidence: 99%

Effects of cardiopulmonary bypass and hypothermia on electroencephalographic variables

et al. 1997

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SummaryWe studied the effects of hypothermia and cardiopulmonary bypass (CPB) on four depth of anaesthesia monitors; spectral edge frequency (SEF), median frequency (MF), bispectral index (BIS) and auditory evoked potential index (AEPIndex) in 12 patients during uneventful cardiac anaesthesia. Each variable was recorded simultaneously at 10 periods during anaesthesia. All four variables were not affected by the transition to CPB. During hypothermia, values of AEPIndex, MF and SEF were tightly distributed but values of BIS were very variable and overlapped with those before induction of anaesthesia. The variability decreased during rewarming. The values of AEPIndex throughout the anaesthesia never overlapped with those before induction of anaesthesia. The AEPIndex was the most stable and reliable as a depth of anaesthesia monitor among the four variables in cardiac bypass surgery.

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Auditory Evoked Potentials During Propofol Anaesthesia in Man

Cited by 38 publications

References 26 publications

Effects of different propofol infusion rates on EEG activity and AEP responses in rats

Effects of different propofol infusion rates on EEG activity and AEP responses in rats

Block-dependent sedation during epidural anaesthesia is associated with delayed brainstem conduction

Effects of cardiopulmonary bypass and hypothermia on electroencephalographic variables

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