Auditory evoked potentials might have the potential to serve as early indicators related to amyloid beta peptide toxicity

Hidişoğlu, Enis; Yargiçoğlu, Pi̇raye

doi:10.1016/j.advms.2020.02.001

Cited by 6 publications

(6 citation statements)

References 43 publications

(44 reference statements)

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“…The sensory P1 peak in AD mice appeared smaller than WT mice at young ages (<8 months old) ( Figures 3 , 4 , 6 ). These data are consistent with previous reports that AD or amyloid injection could reduce evoked potentials in the AC and other brain cortexes in animal models ( Wang et al, 2003 ; Stoiljkovic et al, 2019 ; Hidisoglu and Yargicoglu, 2020 ; Kim et al, 2020 ). These data also indicated that AD could result in functional changes in the AC at the early AD stage.…”

Section: Discussionsupporting

confidence: 93%

“…In previous studies, auditory-evoked potentials were recorded in the cortex, hippocampus, and other brain areas with implanted electrodes in AD animal models ( Wang et al, 2003 ; Stoiljkovic et al, 2019 ) or amyloid-β (Aβ) injected in the rat and mouse brain at different ages ( Hidisoglu and Yargicoglu, 2020 ; Kim et al, 2020 ). In general, auditory-evoked potentials in the AC and other brain cortexes were reduced in AD or amyloid-injected animals.…”

Section: Introductionmentioning

confidence: 99%

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Early Functional and Cognitive Declines Measured by Auditory-Evoked Cortical Potentials in Mice With Alzheimer’s Disease

Mei

Liu

Chen

et al. 2021

Front. Aging Neurosci.

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Alzheimer’s disease (AD) is characterized by a progressive loss of memory and cognitive decline. However, the assessment of AD-associated functional and cognitive changes is still a big challenge. Auditory-evoked cortical potential (AECP) is an event-related potential reflecting not only neural activation in the auditory cortex (AC) but also cognitive activity in the brain. In this study, we used the subdermal needle electrodes with the same electrode setting as the auditory brainstem response (ABR) recording and recorded AECP in normal aging CBA/CaJ mice and APP/PS1 AD mice. AECP in mice usually appeared as three positive peaks, i.e., P1, P2, and P3, and three corresponding negative peaks, i.e., N1, N2, and N3. In normal aging CBA mice, the early sensory peaks P1, N1, and P2 were reduced as age increased, whereas the later cognitive peaks N2, P3, and N3 were increased or had no changes with aging. Moreover, the latency of the P1 peak was increased as age increased, although the latencies of later peaks had a significant reduction with aging. In AD mice, peak P1 was significantly reduced in comparison with wild-type (WT) littermates at young ages, proceeding AD phenotype presentation. In particular, the later cognitive peak P3 was diminished after 3 months old, different from the normal aging effect. However, the latencies of AECP peaks in AD mice generally had no significant delay or changes with aging. Finally, consistent with AECP changes, the accumulation of amyloid precursor protein (APP) at the AC was visible in AD mice as early as 2 months old. These data suggest that AECP could serve as an early, non-invasive, and objective biomarker for detecting AD and AD-related dementia (ADRD).

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Early Functional and Cognitive Declines Measured by Auditory-Evoked Cortical Potentials in Mice With Alzheimer’s Disease

Mei

Liu

Chen

et al. 2021

Front. Aging Neurosci.

View full text Add to dashboard Cite

show abstract

“…3, 4, and 6). These data are consistent with previous reports that AD or amyloid injection could reduce evoked potentials in the auditory cortex and other brain cortexes in animal models (Wang et al, 2003; Stoiljkovic et al, 2019; Kim et al, 2020; Hidisoglu and Yargicoglu, 2020). These data also indicated that AD could result into functional changes in the auditory cortex at the early AD stage.…”

Section: Discussionsupporting

confidence: 93%

“…In previous studies, auditory evoked potentials were recorded in the cortex, hippocampus, and other brain areas with implanted electrodes in AD animal models (Wang et al, 2003;Stoiljkovic et al, 2019) or amyloid-β (Aβ) injected in the rat and mouse brain at different ages (Kim et al, 2020;Hidisoglu and Yargicoglu, 2020). In general, auditory evoked potentials in the auditory cortex and other brain cortexes were reduced in AD or amyloid injected animals.…”

Section: Introductionmentioning

confidence: 99%

Early functional and cognitive declines measured by auditory evoked cortical potentials in Alzheimer’s disease mice

Mei

Liu

Chen

et al. 2021

Preprint

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Alzheimer's disease (AD) is characterized with a progressive loss of memory and cognitive decline. Early detection of AD is critical for prevention and intervention of this common neurodegenerative disease. Previous studies demonstrated that auditory dysfunction could occur at the early stage of AD. Auditory evoked cortical potential (AECP) is an event-related potential reflecting not only neural activation in the auditory cortex but also cognitive activity in the brain. In this study, we recorded AECP in AD mice. AECP in mice usually possessed 3 waveforms. The early sensory P1 and P2 peaks were clearly visible in 1 month old mice. However, the later cognitive P3 peak was not well-developed until the age of 3 months old. In APP/PS1 AD mice, P1 and P2 were reduced at young ages (<6 months old), prior to occurrence of AD phenotypes. Different from normal aging, the cognitive peak of P3 in AD mice was diminished invisible after 4 months old. The latencies of peak N1, P2, and N2 in AD mice before 3 months were shorter than those in WT mice. Consistent with AECP changes, expression of amyloid precursor protein (APP) was visible in the AD mouse auditory cortex at 2 months old. These data indicate that AECP has significant changes in young AD mice and can serve as an early, non-invasive, objective biomarker in AD and AD-related dementia detection and diagnosis.

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“…During the experiments, the animals were monitored via a video camera system mounted in the experimental room. Amplitudes were measured as the voltage between successive peaks (the negative (N1) and the positive (P1) potentials), based on the study of Hidisoglu and Yargicoglu (2020). Data recording was checked on the computer screen.…”

Section: Set-up Stimulus Generation and Aeps Recordingmentioning

confidence: 99%

Análise dos efeitos da modulação GLU cortical sobre a expressão da resposta eletrofisiológica eliciada em ratos tratados com KET e testados em um modelo de condicionamento contextual

Incrocci

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Auditory evoked potentials might have the potential to serve as early indicators related to amyloid beta peptide toxicity

Cited by 6 publications

References 43 publications

Early Functional and Cognitive Declines Measured by Auditory-Evoked Cortical Potentials in Mice With Alzheimer’s Disease

Early Functional and Cognitive Declines Measured by Auditory-Evoked Cortical Potentials in Mice With Alzheimer’s Disease

Early functional and cognitive declines measured by auditory evoked cortical potentials in Alzheimer’s disease mice

Análise dos efeitos da modulação GLU cortical sobre a expressão da resposta eletrofisiológica eliciada em ratos tratados com KET e testados em um modelo de condicionamento contextual

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