Auditory function in young patients with type 1 diabetes mellitus

Ferrer, J.; Biurrun, O; Lorente, Juan; Conget, J I; España, Rafael de; Esmatjes, Enric; Gomis, Ramón

doi:10.1016/0168-8227(91)90136-2

Cited by 43 publications

(30 citation statements)

References 7 publications

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“…In some studies the evaluation of hearing impairment and diabetes in human subjects showed a gradually progressive, bilateral, high frequency hearing loss by using pure tone audiometry (Taylor and Irwin 1978; Kurien et al 1989; Parving et al 1990; Ferrer et al 1991; Elamin et al 2005; Sakuta et al 2007). However others did not find any association of hearing loss with diabetes (Dalton et al 1998; Gratton and Vazquez 2003; Salvinelli et al 2004; Gates and Mills 2005).…”

Section: Discussionmentioning

confidence: 99%

Interactions of hearing loss and diabetes mellitus in the middle age CBA/CaJ mouse model of presbycusis

et al. 2009

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Recently, we characterized the more severe nature of hearing loss in aged Type 2 diabetic human subjects. The current study prospectively assessed hearing abilities in middle age CBA/CaJ mice with Type 1 diabetes mellitus (T1DM) (STZ injection) or Type 2 diabetes mellitus (T2DM) (high fat diet), for a period of 6 months. Blood glucose, body weight and auditory tests (Auditory Brainstem Response-ABR, Distortion Product Otoacoustic Emissions-DPOAE) were evaluated at baseline and every 2 months. Tone and broadband noise-burst responses in the inferior colliculus were obtained at 6 months. Body weights of controls did not change over 6 months (~32g), but there was a significant (~5g) decline in the T1DM, while T2DM exhibited ~10g weight gain. Blood glucose levels significantly increased: 3 fold for T1DM, 1.3 fold for T2DM; with no significant changes in controls. ABR threshold elevations were found for both types of diabetes, but were most pronounced in the T2DM, starting as early as 2 months after induction of diabetes. A decline of mean DPOAE amplitudes was observed in both diabetic groups at high frequencies, and for the T2DM at low frequencies. In contrast to ABR thresholds, tone and noise thresholds in the inferior colliculus were lower for both diabetic groups. Induction of diabetes in middle-aged CBA/CaJ mice promotes amplification of age-related peripheral hearing loss which makes it a suitable model for studying the interaction of age-related hearing loss and diabetes. On the other hand, initial results of effects from very high blood glucose level (T1DM) on the auditory midbrain showed disruption of central inhibition, increased response synchrony or enhanced excitation in the inferior colliculus.

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Section: Discussionmentioning

confidence: 99%

Interactions of hearing loss and diabetes mellitus in the middle age CBA/CaJ mouse model of presbycusis

et al. 2009

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“…Reports (2,3) indicating that audiometric hearing thresholds are correlated with diabetes complications, poor glycemic control, or diabetes duration are often not corroborated (4–6). Although cardiovascular disease and its risk factors, including smoking, have been linked to hearing impairment in the general population (7,8), these associations are unsubstantiated among people with diabetes.…”

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confidence: 99%

Risk Factors for Hearing Impairment Among U.S. Adults With Diabetes

2011

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OBJECTIVEThe objective of this study was to examine the risk factors of low/mid-frequency and high-frequency hearing impairment among a nationally representative sample of diabetic adults.RESEARCH DESIGN AND METHODSData came from 536 participants, aged 20–69 years, with diagnosed or undiagnosed diabetes who completed audiometric testing during 1999–2004 in the National Health and Nutrition Examination Survey (NHANES). We defined hearing impairment as the pure-tone average >25 dB hearing level of pure-tone thresholds at low/mid-frequencies (500; 1,000; and 2,000 Hz) and high frequencies (3,000; 4,000; 6,000; and 8,000 Hz) and identified independent risk factors using logistic regression.RESULTSControlling for age, race/ethnicity, and marital status, odds ratios for associations with low/mid-frequency hearing impairment were 2.20 (95% CI 1.28–3.79) for HDL <40 mg/dL and 3.55 (1.57–8.03) for poor health. Controlling for age, race/ethnicity, sex, and income-to-poverty ratio, odds ratios for associations with high-frequency hearing impairment were 4.39 (1.26–15.26) for history of coronary heart disease and 4.42 (1.26–15.45) for peripheral neuropathy.CONCLUSIONSLow HDL, coronary heart disease, peripheral neuropathy, and having poor health are potentially preventable correlates of hearing impairment for people with diabetes. Glycemic control, years since diagnosis, and type of glycemic medication were not associated with hearing impairment.

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“…Other clinical trials have been able to show means of auditory thresholds of diabetic patients higher than those of control group in all frequencies [20,21]. The fact that this difference is slight could explain why hearing symptoms are not usually valued or stated.…”

Section: Discussionmentioning

confidence: 99%