Auditory induction of an abnormal pattern of behavior in rats.

Morgan, Clifford T.; Morgan, J. D.

doi:10.1037/h0058757

Cited by 50 publications

(30 citation statements)

References 2 publications

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“…and Watson (1939) have shown that both waltzing and epilepsy (convulsive reaction produced by jingling of keys) in mice are transmitted as a Mendelian recessive trait. A similar convulsive reaction to auditory stimulation in rats has been reported by Maier (1939), Morgan and Morgan (1939), Humphrey and Marcuse (1939), Hall (1940), Bayroff (1940) and Maier and Glaser (1940). The latter suggested that the reaction in rats as in mice was probably hereditarily determined.…”

supporting

confidence: 82%

Studies of abnormal behavior in the rat. V. The inheritance of the "neurotic pattern."

Maier¹,

Glaser²

1940

Journal of Comparative Psychology

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supporting

confidence: 82%

Studies of abnormal behavior in the rat. V. The inheritance of the "neurotic pattern."

Maier¹,

Glaser²

1940

Journal of Comparative Psychology

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“…Genetic reflex epilepsy (GRE), which was first described by Morgan and Morgan (1939) [1] , is a type of idiopathic epilepsy in which a stimulus of any sensory modality evokes paroxysmal manifestations only in genetically predisposed subjects. This may occur in humans and animals: the epileptic manifestations are similar among various species, and range from a simple paroxysmal electrical discharge to generalized seizures (see [2] ).…”

Section: Introductionmentioning

confidence: 99%

Epilepsy Caused by an Abnormal Alternative Splicing with Dosage Effect of the SV2A Gene in a Chicken Model

et al. 2011

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Photosensitive reflex epilepsy is caused by the combination of an individual's enhanced sensitivity with relevant light stimuli, such as stroboscopic lights or video games. This is the most common reflex epilepsy in humans; it is characterized by the photoparoxysmal response, which is an abnormal electroencephalographic reaction, and seizures triggered by intermittent light stimulation. Here, by using genetic mapping, sequencing and functional analyses, we report that a mutation in the acceptor site of the second intron of SV2A (the gene encoding synaptic vesicle glycoprotein 2A) is causing photosensitive reflex epilepsy in a unique vertebrate model, the Fepi chicken strain, a spontaneous model where the neurological disorder is inherited as an autosomal recessive mutation. This mutation causes an aberrant splicing event and significantly reduces the level of SV2A mRNA in homozygous carriers. Levetiracetam, a second generation antiepileptic drug, is known to bind SV2A, and SV2A knock-out mice develop seizures soon after birth and usually die within three weeks. The Fepi chicken survives to adulthood and responds to levetiracetam, suggesting that the low-level expression of SV2A in these animals is sufficient to allow survival, but does not protect against seizures. Thus, the Fepi chicken model shows that the role of the SV2A pathway in the brain is conserved between birds and mammals, in spite of a large phylogenetic distance. The Fepi model appears particularly useful for further studies of physiopathology of reflex epilepsy, in comparison with induced models of epilepsy in rodents. Consequently, SV2A is a very attractive candidate gene for analysis in the context of both mono- and polygenic generalized epilepsies in humans.

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“…It is relevant to consider the similarities and differences which this case shows with the audiogenic fits in rats investigated by many workers (Maier, 1939;Morgan and Morgan, 1939;Maier and Glaser, 1940;Lindsley and others, 1942). In certain strains of rats, though not carried as a simple mendelian dominant, a susceptibility to abnormal behaviour culminating in convulsions is found as a response to high-pitched sounds (whistle, keyjingling, etc.).…”

Section: Discussionmentioning

confidence: 65%