Auditory interhemispheric transfer in relation to patterns of partial agenesis and hypoplasia of the corpus callosum in spina bifida meningomyelocele

Hannay, H. Julia; Walker, Amy; Dennis, Maureen; Kramer, Larry A.; Blaser, Susan; Fletcher, Jack Μ.

doi:10.1017/s1355617708080958

Cited by 19 publications

(30 citation statements)

References 57 publications

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“…There are several possible reasons for the small cGC values that are observed. First, the effective connectivity between hemispheres may be small in the absence of a task requiring interhemispheric interaction, which is consistent with neuropsychological studies (Hannay et al, 2008). The rhythmic oscillations that tend to dominate the eyes-closed resting condition are very well explained by their own past.…”

Section: Malekpour Et Alsupporting

confidence: 81%

“…Reduced effective and functional connectivity are consistent with the cognitive deficits observed in SBH children for operations dependent on the interhemispheric integration of function (Hannay et al, 2008;Klaas et al, 1999). The anterior cGC and coherence are generally higher in the SBH group than the control group.…”

Section: Discussionsupporting

confidence: 70%

“…Subjects with spina bifida and hydrocephalus (SBH) often have anatomical dysgenesis and hypoplasia (thinning) of the posterior portion of the corpus callosum (Hannay et al, 2008). Recent studies have demonstrated that along with a variety of sensorimotor and cognitive deficits (Dennis et al, 2010;Simos et al, 2011), specific cognitive operations relying on the interhemispheric integration of function are significantly affected in children with SBH, most prominently in cases where partial agenesis of the corpus callosum is present (Hannay et al, 2008;Klaas et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

“…Recent studies have demonstrated that along with a variety of sensorimotor and cognitive deficits (Dennis et al, 2010;Simos et al, 2011), specific cognitive operations relying on the interhemispheric integration of function are significantly affected in children with SBH, most prominently in cases where partial agenesis of the corpus callosum is present (Hannay et al, 2008;Klaas et al, 1999). It is likely that compromised interhemispheric effective connectivity is a cause of this loss of function, especially considering the corresponding reduced anatomical connectivity.…”

Section: Introductionmentioning

confidence: 99%

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Interhemispheric Effective and Functional Cortical Connectivity Signatures of Spina Bifida Are Consistent with Callosal Anomaly

Malekpour

Cheung

et al. 2012

Brain Connectivity

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The impact of the posterior callosal anomalies associated with spina bifida on interhemispheric cortical connectivity is studied using a method for estimating cortical multivariable autoregressive models from scalp magnetoencephalography data. Interhemispheric effective and functional connectivity, measured using conditional Granger causality and coherence, respectively, is determined for the anterior and posterior cortical regions in a population of five spina bifida and five control subjects during a resting eyes-closed state. The estimated connectivity is shown to be consistent over the randomly selected subsets of the data for each subject. The posterior interhemispheric effective and functional connectivity and cortical power are significantly lower in the spina bifida group, a result that is consistent with posterior callosal anomalies. The anterior interhemispheric effective and functional connectivity are elevated in the spina bifida group, a result that may reflect compensatory mechanisms. In contrast, the intrahemispheric effective connectivity is comparable in the two groups. The differences between the spina bifida and control groups are most significant in the h and a bands.

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Section: Malekpour Et Alsupporting

confidence: 81%

Section: Discussionsupporting

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Interhemispheric Effective and Functional Cortical Connectivity Signatures of Spina Bifida Are Consistent with Callosal Anomaly

Malekpour

Cheung

et al. 2012

Brain Connectivity

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“…Three measures previously correlated with area measurements of the CC (Fletcher et al, 1996) were used for this study: Stanford-Binet Test of Intelligence (Thorndike et al, 1986), Purdue Pegboard (Tiffin, 1968), and dichotic listening (Hannay et al, 2008).…”

Section: Neurobehavioral Measuresmentioning

confidence: 99%

Structure, Integrity, and Function of the Hypoplastic Corpus Callosum in Spina Bifida Myelomeningocele

et al. 2014

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Although there are many studies of people with complete or partial hypogenesis of the corpus callosum (CC), little is understood about the hypoplastic CC in which all structures are present but thinned. Spina bifida myelomeningocele (SBM) is a model organism for such studies because many have either a hypogenetic or hypoplastic CC. We used diffusion tensor tractography (DTT) to evaluate the hypoplastic CC in SBM and its relation to interhemispheric functions and intelligence quotient (IQ). Participants were individuals with SBM and an intact or hypoplastic CC (n = 28), who were compared to a typically developing comparison group (n = 32). Total and regional DTT volume and integrity measures (fractional anisotropy, axial diffusivity, and radial diffusivity) of the CC were related to measures of intelligence (IQ), bimanual motor functioning, and dichotic auditory performance. As predicted, DTT showed variations in volume and integrity that were maximized in the entire CC and the posterior CC. IQ correlated with entire CC volume, anterior and posterior regional CC volumes, and also with measures of integrity. Bimanual motor functioning correlated with the anterior and posterior volumes of the CC but not with any integrity measures. Axial diffusivity in the posterior CC was negatively correlated with right ear dichotic listening performance. The hypoplastic CC is not macrostructurally or microstructurally intact in SBM, even when it appears radiologically intact. Both volume and integrity of the posterior regions were related to reductions in IQ and to interhemispheric processing. These findings may transfer to other disorders characterized by a hypoplastic CC.

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Anomalous development of brain structure and function in spina bifida myelomeningocele

Juranek

Salman

2010

Dev Disabil Res Revs

119

123

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Spina bifida myelomeningocele (SBM) is a specific type of neural tube defect whereby the open neural tube at the level of the spinal cord alters brain development during early stages of gestation. Some structural anomalies are virtually unique to individuals with SBM, including a complex pattern of cerebellar dysplasia known as the Chiari II malformation. Other structural anomalies are not necessarily unique to SBM, including altered development of the corpus callosum and posterior fossa. Within SBM, tremendous heterogeneity is reflected in the degree to which brain structures are atypical in qualitative appearance and quantitative measures of morphometry. Hallmark structural features of SBM include overall reductions in posterior fossa and cerebellum appearance, size, and volume. Studies of the corpus callosum have shown complex patterns of agenesis or hypoplasia along its rostral-caudal axis, with rostrum and splenium regions particularly susceptible to agenesis. Studies of cortical regions have demonstrated complex patterns of thickening, thinning, and gyrification. Diffusion tensor imaging studies have reported compromised integrity of some specific white matter pathways. Given equally complex ocular motor, motor, and cognitive phenotypes consisting of relative strengths and weaknesses that seem to align with altered structural development, studies of SBM provide new insights to our current understanding of brain structure-function associations.

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Auditory interhemispheric transfer in relation to patterns of partial agenesis and hypoplasia of the corpus callosum in spina bifida meningomyelocele

Cited by 19 publications

References 57 publications

Interhemispheric Effective and Functional Cortical Connectivity Signatures of Spina Bifida Are Consistent with Callosal Anomaly

Interhemispheric Effective and Functional Cortical Connectivity Signatures of Spina Bifida Are Consistent with Callosal Anomaly

Structure, Integrity, and Function of the Hypoplastic Corpus Callosum in Spina Bifida Myelomeningocele

Anomalous development of brain structure and function in spina bifida myelomeningocele

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