Auditory Mismatch Negativity in Youth Affected by Autism Spectrum Disorder With and Without Attenuated Psychosis Syndrome

Lorenzo, Giorgio Di; Riccioni, Assia; Ribolsi, Michele; Siracusano, Martina; Curatolo, Paolo; Mazzone, Luigi

doi:10.3389/fpsyt.2020.555340

Cited by 7 publications

(11 citation statements)

References 68 publications

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“…By contrast, in line with previous studies [ 41 , 42 , 43 ] we found a reduced MMN amplitude in the autistic population. However, no significant abnormalities emerged in the HIP group, which showed a mean MMN amplitude similar to that of NTD subjects.…”

Section: Discussionsupporting

confidence: 93%

“…ERPs represent a non-invasive method broadly investigated in neuropsychiatric research activities [ 34 ] to evaluate neurocognitive and attentive processes. Among ERPs, the mismatch negativity (MMN) and the P300 component have been widely explored in neurodevelopmental disorders [ 35 , 36 , 37 , 38 , 39 ] including autism [ 40 , 41 , 42 , 43 ].…”

Section: Introductionmentioning

confidence: 99%

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High Intellectual Potential and High Functioning Autism: Clinical and Neurophysiological Features in a Pediatric Sample

et al. 2021

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High Intellectual Potential (HIP) and High Functioning Autism (HFA) are two different conditions sharing some clinical and neurobiological features. The aim of the present study was to characterize a sample of HIP children (n: 16; M/F: 14/2; median age: 10 years) in comparison to those with HFA (n: 17; M/F: 16/1; median age: 13 years) and to neurotypically developed (NTD) children (n: 10; M/F: 4/6; median age: 11 years) from a clinical and neurophysiological perspective. Specifically, a standardized clinical assessment of cognitive and adaptive skills, autistic symptoms, executive functions and behavioral features was performed. Moreover, event-related potentials (ERPs) were recorded, referring specifically to the mismatch negativity (MMN) and P300 paradigm. Our data highlighted the presence of similarities between the intellectually gifted individuals and the ones with autism (i.e., a nonhomogeneous intellective profile, an adaptive skills impairment, subthreshold autistic symptoms and increased perfectionism). Interestingly, a distinct neurophysiological characterization between groups came out, with evidence of a reduced MMN amplitude only in the HFA group. Furthermore, no differences within groups in the P300 component emerged. Therefore, our results start to provide a more informative characterization of the HIP phenotype in comparison to those of HFA and NTD, highlighting the potential role of the MMN amplitude index in helping clinicians and researchers to distinguish between HIP and HFA. Nevertheless, further research on the topic is strongly needed.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

High Intellectual Potential and High Functioning Autism: Clinical and Neurophysiological Features in a Pediatric Sample

et al. 2021

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“…There is growing consensus that MMN is attenuated in autism compared to controls. The majority of studies have reported attenuated MMN amplitudes in children and adolescents with autism (Abdeltawwab & Baz, 2015; Di Lorenzo et al, 2020; Dunn et al, 2008; Huang et al, 2018; Lepisto et al, 2005; Lepisto et al, 2006; Ruiz‐Martinez et al, 2020; Vlaskamp et al, 2017), although a few studies found increased MMN amplitudes (Ferri et al, 2003; Lepisto et al, 2005; Yu et al, 2015) or no differences in MMN amplitudes (Chien et al, 2018; Gomot et al, 2011; Hudac et al, 2018; Jansson‐Verkasalo et al, 2003; Weismuller et al, 2015). However, a recent meta‐analysis (Chen et al, 2020) concluded that compared to controls, the MMN amplitudes in response to both speech‐sound and tone‐duration deviants are decreased in children but not adults with autism.…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, results on whether the timing of the MMN peak differs in autism are inconsistent, as studies report both shorter MMN latencies (Gomot et al, 2002; Gomot et al, 2011; Vlaskamp et al, 2017), prolonged MNN latencies (Abdeltawwab & Baz, 2015; Di Lorenzo et al, 2020; Huang et al, 2018) and no difference in latencies (Yu et al, 2015) in children and adolescents with autism. Many studies have additionally explored if children with autism display abnormal brain potentials as sensory deviants enters awareness.…”

Section: Introductionmentioning

confidence: 99%

Reduced mismatch negativity in children and adolescents with autism spectrum disorder is associated with their impaired adaptive functioning

et al. 2022

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“…Therefore, it is now widely used in clinical applications for the diagnosis of certain neurological deficits. Relevant studies have shown that compared with healthy children, patients with ASD have robust MMN deficits, thus suggesting an altered central ability in auditory discrimination ( Vlaskamp et al, 2017 ; Chen et al, 2020 ; Di Lorenzo et al, 2020 ). In the current study, a single-blind, sham-controlled experiment was designed for subjects with ASD.…”

Section: Introductionmentioning

confidence: 99%

Effect of Transcranial Direct Current Stimulation on the Mismatch Negativity Features of Deviated Stimuli in Children With Autism Spectrum Disorder

Sun

Zhao

Cheng³

et al. 2022

Front. Neurosci.

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Autism spectrum disorder (ASD) is a devastating mental disorder in children. Currently, there is no effective treatment for ASD. Transcranial direct current stimulation (tDCS), which is a non-invasive brain stimulation neuromodulation technology, is a promising method for the treatment of ASD. However, the manner in which tDCS changes the electrophysiological process in the brain is still unclear. In this study, we used tDCS to stimulate the dorsolateral prefrontal cortex area of children with ASD (one group received anode tDCS, and the other received sham tDCS) and investigated the changes in evoked EEG signals and behavioral abilities before and after anode and sham stimulations. In addition to tDCS, all patients received conventional rehabilitation treatment. Results show that although conventional treatment can effectively improve the behavioral ability of children with ASD, the use of anode tDCS with conventional rehabilitation can boost this improvement, thus leading to increased treatment efficacy. By analyzing the electroencephalography pre- and post-treatment, we noticed a decrease in the mismatch negativity (MMN) latency and an increase in the MMN amplitude in both groups, these features are considered similar to MMN features from healthy children. However, no statistical difference between the two groups was observed after 4 weeks of treatment. In addition, the MMN features correlate well with the aberrant behavior checklist (ABC) scale, particularly the amplitude of MMN, thus suggesting the feasibility of using MMN features to assess the behavioral ability of children with ASD.

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Auditory Mismatch Negativity in Youth Affected by Autism Spectrum Disorder With and Without Attenuated Psychosis Syndrome

Cited by 7 publications

References 68 publications

High Intellectual Potential and High Functioning Autism: Clinical and Neurophysiological Features in a Pediatric Sample

High Intellectual Potential and High Functioning Autism: Clinical and Neurophysiological Features in a Pediatric Sample

Reduced mismatch negativity in children and adolescents with autism spectrum disorder is associated with their impaired adaptive functioning

Effect of Transcranial Direct Current Stimulation on the Mismatch Negativity Features of Deviated Stimuli in Children With Autism Spectrum Disorder

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