Auditory motion perception activates visual motion areas in early blind subjects

Poirier, Colline; Collignon, Olivier; Scheiber, Christian; Renier, Laurent; Vanlierde, Annick; Tranduy, Daï; Veraart, Claude; Volder, Anne De

doi:10.1016/j.neuroimage.2005.11.036

Cited by 209 publications

(184 citation statements)

References 56 publications

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“…A previous study of early-blind subjects reported auditory ILD motion responses in a region consistent with MTϩ location, and we have replicated this result in five blind subjects (data not shown), suggesting that similar cross-modal responses may exist in individuals who are still blind (Poirier et al, 2005(Poirier et al, , 2006). However, as described above, it is not possible to functionally verify MTϩ location in subjects who are blind.…”

Section: Previous Studies Of Cross-modal Responses In Mt؉supporting

confidence: 86%

“…However, as described above, it is not possible to functionally verify MTϩ location in subjects who are blind. Nor did Poirier et al (2005Poirier et al ( , 2006 test whether the responses that they found near the presumed location of MTϩ were selective for motion stimuli. Interestingly, another study in early-blind subjects reported acquired tactile motion responses in a region consistent with MTϩ (Ricciardi et al, 2007).…”

Section: Previous Studies Of Cross-modal Responses In Mt؉mentioning

confidence: 98%

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Visual Motion Area MT+/V5 Responds to Auditory Motion in Human Sight-Recovery Subjects

et al. 2008

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Using functional magnetic resonance imaging, we found that cortical visual motion area MTϩ/V5 responded to auditory motion in two rare subjects who had been blind since early childhood and whose vision was partially recovered in adulthood. Visually normal control subjects did not show similar auditory responses. These auditory responses in MTϩ were specific to motion compared with other complex auditory stimuli including frequency sweeps and speech. Thus, MTϩ developed motion-specific responses to nonvisual input, suggesting that cross-modal plasticity can be influenced by the normal functional specialization of a cortical region. Regarding sight recovery after early blindness, our results further demonstrate that cross-modal responses coexist with regained visual responses within the visual cortex.

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Section: Previous Studies Of Cross-modal Responses In Mt؉supporting

confidence: 86%

Section: Previous Studies Of Cross-modal Responses In Mt؉mentioning

confidence: 98%

Visual Motion Area MT+/V5 Responds to Auditory Motion in Human Sight-Recovery Subjects

et al. 2008

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“…Many functional imaging studies reported that the visual cortex of the early blind was activated during performing different tasks, such as language processing [Amedi et al, 2003;Buchel et al, 1998;Burton et al, 2002], tactile discrimination Sadato et al, 1996Sadato et al, , 1998], and auditory stimuli [Kujala et al, 2005;Poirier et al, 2006]. These studies suggest that the visual cortex is functionally reorganized due to early visual deprivation.…”

Section: Introductionmentioning

confidence: 99%

Abnormal diffusion of cerebral white matter in early blindness

Shu

et al. 2007

Human Brain Mapping

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Early visual deprivation may lead to both abnormal and plastic changes in the visual and other systems of the brain. Such secondary changes in the gray matter of the early blind have been well studied, but not so well in the cerebral white matter whose subtle changes may be revealed by diffusion tensor imaging. The first purpose of this study is to explore the possible changed white matter regions of the early blind in whole brain manners, using voxel-based analysis (VBA) and tract-based spatial statistics (TBSS) methods. The second purpose is to investigate the changes of diffusion eigenvalues in the abnormal white matter fiber tracts using tractography based group mapping analysis. From VBA of fractional anisotropy (FA) images, the significant changed white matter regions were the geniculocalcarine tract (GCT) and its adjacent regions. This finding was validated by TBSS method. Then we studied the changes of mean diffusivity (MD), FA, primary (k 1 ) and transverse diffusivities (k 23 ) in the GCT using tractography based group mapping analysis. We found the early blind had significantly lower FA (P < 0.0001), higher MD (P 5 0.001) and k 23 (P < 0.0001) in the GCT. This pattern of diffusion changes is similar to findings seen in immaturity or axonal degeneration. Thus, we suggest that transneuronal degeneration and/or immaturity may account for the abnormal diffusion changes in the GCT of the early blind.

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“…Alternatively, another perspective on dorsal and ventral visual processing streams rather considers them to be involved in the control of object-directed actions and object recognition, respectively (12). Interestingly, recent studies in CB have reported task-specific responses in ventral (13)(14)(15)(16) and dorsal (17)(18)(19)(20)(21)(22) occipital streams in response to "what" and "where" nonvisual processing. For example, Renier et al (22) have recently found that the middle occipital gyrus (MOG) is preferentially activated by the spatial processing of nonvisual inputs.…”

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confidence: 99%

Functional specialization for auditory–spatial processing in the occipital cortex of congenitally blind humans

Collignon

Vandewalle

Voss

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

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The study of the congenitally blind (CB) represents a unique opportunity to explore experience-dependant plasticity in a sensory region deprived of its natural inputs since birth. Although several studies have shown occipital regions of CB to be involved in nonvisual processing, whether the functional organization of the visual cortex observed in sighted individuals (SI) is maintained in the rewired occipital regions of the blind has only been recently investigated. In the present functional MRI study, we compared the brain activity of CB and SI processing either the spatial or the pitch properties of sounds carrying information in both domains (i.e., the same sounds were used in both tasks), using an adaptive procedure specifically designed to adjust for performance level. In addition to showing a substantial recruitment of the occipital cortex for sound processing in CB, we also demonstrate that auditory-spatial processing mainly recruits the right cuneus and the right middle occipital gyrus, two regions of the dorsal occipital stream known to be involved in visuospatial/motion processing in SI. Moreover, functional connectivity analyses revealed that these reorganized occipital regions are part of an extensive brain network including regions known to underlie audiovisual spatial abilities (i.e., intraparietal sulcus, superior frontal gyrus). We conclude that some regions of the right dorsal occipital stream do not require visual experience to develop a specialization for the processing of spatial information and to be functionally integrated in a preexisting brain network dedicated to this ability.blindness | cross-modal plasticity | ventral-dorsal auditory streams | modularity W hen the brain is deprived of its natural sensory inputs, it can rewire itself, showing an impressive range of plastic changes (1). Early visual deprivation thus provides an exceptional model to explore the role of sensory experience in shaping the functional architecture of the brain. Based on a number of studies comparing brain activity of congenitally blind (CB) and sighted individuals (SI), the current prevailing view is that visual deafferentation results in a reliable recruitment of the occipital cortex for nonvisual sensory processing to compensate for the challenging condition that is visual deprivation (2).Although such findings highlight the brain's remarkable ability to rewire its components, questions remain about the functional organization of the occipital cortex in CB. An important characteristic of the visual cortex in SI is domain specialization wherein specific functional activity has been found in anatomically identifiable regions (3, 4). Our main question was, therefore: does the occipital cortex of CB process the colonizing nonvisual stimuli in a global manner or does it do so using some functional modularity similar to what is observed in SI, with precise regions involved in specific cognitive functions?Several studies have reported that the occipital cortex of CB responds quite indifferently to a variety of cogn...

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Auditory motion perception activates visual motion areas in early blind subjects

Cited by 209 publications

References 56 publications

Visual Motion Area MT+/V5 Responds to Auditory Motion in Human Sight-Recovery Subjects

Visual Motion Area MT+/V5 Responds to Auditory Motion in Human Sight-Recovery Subjects

Abnormal diffusion of cerebral white matter in early blindness

Functional specialization for auditory–spatial processing in the occipital cortex of congenitally blind humans

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